{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679983306752.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3950/jibiinkoka.95.201"}},{"identifier":{"@type":"PMID","@value":"1560306"}},{"identifier":{"@type":"NAID","@value":"130000805660"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Effects of sex hormones and PTU on growth of transplantable rat thyroid tumor with estrogen receptor (ER)."},{"@value":"エストロゲン・レセプター陽性可移植性ラット甲状腺腫よう株の増殖に及ぼす性ホルモンならびにＰＴＵの影響"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Effects of hormones (E2: estradiol, TP: testosterone) and propylthiouracil (PTU) on the growth of transplantable rat thyroid tumor (F2D1) having estrogen receptors were studied.<br>Rat thyroid neoplasms, induced by N-bis (2-hydroxypropyl) nitrosamine, were inoculated subcutaneously from donor to recipient rats, in order to estalish 16 transplantable rat thyroid tumor lines. The grafts were used for histological studies and for the assay of estrogen receptor (ER) and androgen receptor (AR). Of these lines, we designated papillary carcinoma, which was positive for ER (N: 12.5fmol/mg protein, Kd: 0.4nM) but negative for AR, as F2D1.<br>For studies on the effects of sex hormones and PTU on the growth of transplantable tumors, the rats which had been inoculated with tumors were divided into the following 8 groups; (1) Intact, (2) PTU, (3) ovariectomy (OV), and (4) OV+E2 for female, and (5) Intact, (6) PTU, (7) castration (CA), and (8) CA+TP for male.<br>Results: The growth rate of F2D1 in female rats was decreased by OV, but no change was observed in OV+E2 as compared with Intact. CA and CA+TP in male rats did not influence the growth rate. PTU produced a signigicant increase in the growth rate in both sexes. These results demonstrate that estrogen and PTU act on the growth of ER-positive rat thyroid tumors."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679983306755","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020928339"}],"foaf:name":[{"@language":"en","@value":"TANAKA OSAMU"},{"@language":"ja","@value":"田中 治"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otorhinolaryngology, Nara Medical University"},{"@language":"ja","@value":"奈良県立医科大学耳鼻咽喉科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679983306756","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020928335"}],"foaf:name":[{"@language":"en","@value":"YANE KATSUNARI"},{"@language":"ja","@value":"家根 旦有"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otorhinolaryngology, Nara Medical University"},{"@language":"ja","@value":"奈良県立医科大学耳鼻咽喉科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679983306753","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020928343"}],"foaf:name":[{"@language":"en","@value":"MIYAHARA HIROSHI"},{"@language":"ja","@value":"宮原 裕"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otorhinolaryngology, Nara Medical University"},{"@language":"ja","@value":"奈良県立医科大学耳鼻咽喉科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679983306759","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020928346"}],"foaf:name":[{"@language":"en","@value":"MATSUNAGA TAKASHI"},{"@language":"ja","@value":"松永 喬"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otorhinolaryngology, Nara Medical University"},{"@language":"ja","@value":"奈良県立医科大学耳鼻咽喉科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679983306752","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020928355"}],"foaf:name":[{"@language":"en","@value":"NAKAOKA SHINGO"},{"@language":"ja","@value":"中岡 伸悟"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"奈良県立医科大学第2病理学教室"},{"@language":"en","@value":"Department of Second Pathology, Nara Medical 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YOSHIO"},{"@language":"ja","@value":"日浅 義雄"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"奈良県立医科大学第2病理学教室"},{"@language":"en","@value":"Department of Second Pathology, Nara Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679983306757","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020928361"}],"foaf:name":[{"@language":"en","@value":"NISHIOKA HIROTO"},{"@language":"ja","@value":"西岡 博人"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral and Maxillofacial Surgery, Nara Medical University"},{"@language":"ja","@value":"奈良県立医科大学口腔外科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679983306754","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020928364"}],"foaf:name":[{"@language":"en","@value":"SUGIMURA MASAHITO"},{"@language":"ja","@value":"杉村 正仁"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral and Maxillofacial Surgery, Nara Medical University"},{"@language":"ja","@value":"奈良県立医科大学口腔外科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658378819072","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30221211"},{"@type":"NRID","@value":"1000030221211"},{"@type":"NRID","@value":"9000020002083"},{"@type":"NRID","@value":"9000253400668"},{"@type":"NRID","@value":"9000392747453"},{"@type":"NRID","@value":"9000020928351"},{"@type":"NRID","@value":"9000392741281"},{"@type":"NRID","@value":"9000256831373"},{"@type":"NRID","@value":"9000253400216"},{"@type":"NRID","@value":"9000253401357"},{"@type":"NRID","@value":"9000019994147"},{"@type":"NRID","@value":"9000020367785"},{"@type":"NRID","@value":"9000253401084"},{"@type":"NRID","@value":"9000001214161"},{"@type":"NRID","@value":"9000019994842"},{"@type":"NRID","@value":"9000020009304"},{"@type":"NRID","@value":"9000392751893"},{"@type":"NRID","@value":"9000020022164"},{"@type":"NRID","@value":"9000392745273"},{"@type":"NRID","@value":"9000392750697"},{"@type":"NRID","@value":"9000021530767"},{"@type":"NRID","@value":"9000392746420"},{"@type":"NRID","@value":"9000392745834"},{"@type":"NRID","@value":"9000392744343"},{"@type":"NRID","@value":"9000021573910"},{"@type":"NRID","@value":"9000019989358"}],"foaf:name":[{"@language":"en","@value":"KITAHORI YOSHITERU"},{"@language":"ja","@value":"北堀 吉映"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Second Pathology, Nara Medical University"},{"@language":"ja","@value":"奈良県立医科大学第2病理学教室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00306622"},{"@type":"LISSN","@value":"00306622"},{"@type":"EISSN","@value":"18830854"}],"prism:publicationName":[{"@language":"en","@value":"Nippon Jibiinkoka Gakkai Kaiho"},{"@language":"ja","@value":"日本耳鼻咽喉科学会会報"},{"@language":"en","@value":"Nippon Jibiinkoka Gakkai Kaiho"},{"@language":"ja","@value":"日耳鼻"},{"@language":"ja","@value":"日本耳鼻咽喉科学会会報"},{"@language":"ja","@value":"日耳鼻会報"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Otorhinolaryngology-Head and neck surgery"},{"@language":"ja","@value":"一般社団法人 日本耳鼻咽喉科頭頸部外科学会"}],"prism:publicationDate":"1992","prism:volume":"95","prism:number":"2","prism:startingPage":"201","prism:endingPage":"206"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","availableAt":"1992","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Propylthiouracil%20(PTU)","dc:title":"Propylthiouracil (PTU)"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%A9%E3%83%83%E3%83%88%E7%94%B2%E7%8A%B6%E8%85%BA%E8%85%AB%E7%98%8D","dc:title":"ラット甲状腺腫瘍"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%80%A7%E3%83%9B%E3%83%AB%E3%83%A2%E3%83%B3","dc:title":"性ホルモン"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%85%AB%E7%98%8D%E5%A2%97%E6%AE%96","dc:title":"腫瘍増殖"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A8%E3%82%B9%E3%83%88%E3%83%AD%E3%82%B2%E3%83%B3%E2%80%A2%E3%83%AC%E3%82%BB%E3%83%97%E3%82%BF%E3%83%BC","dc:title":"エストロゲン•レセプター"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0007838764"},{"@type":"CROSSREF","@value":"10.3950/jibiinkoka.95.201"},{"@type":"PUBMED","@value":"1560306"},{"@type":"CIA","@value":"130000805660"},{"@type":"OPENAIRE","@value":"doi_dedup___::94724964872b68e91661f69e3f09ff21"}]}