{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679993215744.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11389/jjrs1963.25.924"}},{"identifier":{"@type":"PMID","@value":"3694972"}},{"identifier":{"@type":"NAID","@value":"130004916213"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Two cases of hypersensitivity pneumonitis due to isocyanate in foundry castworkers."},{"@value":"鋳物工にみられたイソシアネート（ＭＤＩ）による過敏性肺臓炎の２例"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"We reported two cases of hypersensitivity pneumonitis induced by the inhalation of isocyanate (MDI). The patients were 49 and 42 year-old males. They were engaged in casting at the same foundry and were dealing with MDI for two months, when dry cough, fever and exertional dyspnea developed. These symptoms improved while they took leave. Fine crackles were auscultated in both lungs at the inspiratory phase, and restricted pulmonary dysfunction with hypoxemia was noticed. Chest X-ray film revealed diffuse fine granular shadows on both lungs. Alveolitis, epithelioid granulomas and Masson's bodies were demonstrated in transbronchial lung biopsy specimens. Because of positive skin test, positive lymphocyte stimulation test and doubtful precipitation test utilizing isocyanate-human serum albumins, type IV allergy mechanism (Gell-Coombs) might have a significant role in the pathogenesis of this hypersensitivity pneumonitis induced by isocyanate."},{"@value":"イソシアネート (MDI) による過敏性肺臓炎の2症例を経験したので報告する. 症例1:49歳, 男性, 症例2:42歳, 男性. ともに同一の鋳物工場でMDIを扱う冶工具作業に従事して約2ヵ月を経過した頃より, 乾燥咳・発熱・呼吸困難を認め入院. 症状は休職により軽快した. 聴診にて吸気時に fine crackles を聴取し, 呼吸機能検査上低酸素血症と拘束性障害を示した. 胸部X線写真はびまん性粒状影を呈し, TBLBにて胞隔炎, 類上皮細胞肉芽腫病変, Masson 体を認めた. イソシアネート-HSAによる沈降反応は弱陽性にとどまったが, 皮膚反応 (48時間), リンパ球刺激試験は陽性を示し, その発生機序にIV型アレルギーの関与が示唆された."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679993215749","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283521952"}],"foaf:name":[{"@language":"en","@value":"Takazakura Eisuke"},{"@language":"ja","@value":"高桜 英輔"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Internal Medicine, Kurobe Municipal Hospital"},{"@language":"ja","@value":"黒部市民病院内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1030566608406810115","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90155367"},{"@type":"NRID","@value":"1000090155367"},{"@type":"AID","@value":"DA04349264"},{"@type":"NRID","@value":"9000260206921"},{"@type":"NRID","@value":"9000283521953"},{"@type":"NRID","@value":"9000327389994"},{"@type":"NRID","@value":"9000005185546"},{"@type":"NRID","@value":"9000299561933"},{"@type":"NRID","@value":"9000360555918"},{"@type":"NRID","@value":"9000003735215"},{"@type":"NRID","@value":"9000241767116"}],"foaf:name":[{"@language":"en","@value":"Tsuji Hiroshi"},{"@language":"ja","@value":"辻 博"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Internal Medicine, Kurobe Municipal Hospital"},{"@language":"ja","@value":"黒部市民病院内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679993215748","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283521954"}],"foaf:name":[{"@language":"en","@value":"Makino Hiroshi"},{"@language":"ja","@value":"牧野 博"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Internal Medicine, Kurobe Municipal Hospital"},{"@language":"ja","@value":"黒部市民病院内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679993215746","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283521955"}],"foaf:name":[{"@language":"en","@value":"Terada Yasuhito"},{"@language":"ja","@value":"寺田 康人"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Internal Medicine, Kurobe Municipal Hospital"},{"@language":"ja","@value":"黒部市民病院内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679993215744","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283521956"}],"foaf:name":[{"@language":"en","@value":"Sugiura Hitoshi"},{"@language":"ja","@value":"杉浦 仁"}],"jpcoar:affiliationName":[{"@language":"en","@value":"The Second Department of Pathology, Kanazawa University, School of Medicine"},{"@language":"ja","@value":"金沢大学第2病理"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679993215747","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283521957"}],"foaf:name":[{"@language":"en","@value":"Kitagawa Shunsuke"},{"@language":"ja","@value":"北川 駿介"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Internal Medicine Division of Respiratory Diseases, Kanazawa Medical University"},{"@language":"ja","@value":"金沢医科大学呼吸器内科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03011542"},{"@type":"EISSN","@value":"1883471X"}],"prism:publicationName":[{"@language":"en","@value":"The Japanese journal of thoracic diseases"},{"@language":"ja","@value":"日本胸部疾患学会雑誌"},{"@language":"en","@value":"The Japanese journal of thoracic diseases"},{"@language":"ja","@value":"日本胸部疾患学会雑誌"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Respiratory Society"},{"@language":"ja","@value":"社団法人 日本呼吸器学会"}],"prism:publicationDate":"1987","prism:volume":"25","prism:number":"8","prism:startingPage":"924","prism:endingPage":"928"},"availableAt":"1987","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Hypersensitivity%20pneumonitis","dc:title":"Hypersensitivity pneumonitis"},{"@id":"https://cir.nii.ac.jp/all?q=Isocyanate","dc:title":"Isocyanate"},{"@id":"https://cir.nii.ac.jp/all?q=Castworker","dc:title":"Castworker"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%81%8E%E6%95%8F%E6%80%A7%E8%82%BA%E8%87%93%E7%82%8E","dc:title":"過敏性肺臓炎"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A4%E3%82%BD%E3%82%B7%E3%82%A2%E3%83%8D%E3%83%BC%E3%83%88","dc:title":"イソシアネート"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%8B%B3%E7%89%A9%E5%B7%A5","dc:title":"鋳物工"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0017215415"},{"@type":"PUBMED","@value":"3694972"},{"@type":"CIA","@value":"130004916213"},{"@type":"OPENAIRE","@value":"pmid_dedup__::0d3744905bb8ccf9761908d337a7defb"}]}