高比重リポたんぱく（ＨＤＬ）亜分画のコレステロール濃度の臨床的検討

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書誌事項

タイトル別名
  • Quantitation of Cholesterol Levels in HDL Subfractions
  • コウ ヒジュウ リポ タンパク HDL アブンカク ノ コレステロール ノウド

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Interest in human high density lipoprotein (HDL) has grown because of the finding that plasma HDL-cholesterol levels are negatively associated with the incidence of coronary heart disease. Classically, HDL has been divided in two density classes: HDL2 (d, 1.063-1.125mg/dl) and HDL3 (d, 1.125-1.21mg/dl). In the present study, HDL subfractions were separated by the precipitation and ultracentrifugal methods, and we have investigated cholesterol levels in HDL subfractions in healthy, hyperlipoproteinemic subjects and in patients with ischemic heart disease.<br>The results were obtained as follows:<br>HDL-cholesterol levels were significantly higher in healthy females than in males (males 50±12mg/dl, females 57±11mg/dl). HDL2-cholesterol levels were 20.8±8.3mg/dl for men and 27.5±6.6mg/dl for women.<br>Females had also significantly higher HDL2-cholesterol levels than males. On the other hand, healthy male and females had approximately similar HDL3-cholesterol levels. Thus, this finding reported here indicated that variations in HDL-cholesterol levels were largely due to changes in HDL2-cholesterol levels.<br>The ratio of HDL2-cholesterol to HDL3-cholesterol was 0.42±0.08 for men and 0.48±0.09 for women. Females had significantly greater ratio than males.<br>In the invitation of the relationship of cholesterol levels in HDL subfractions to other lipid and lipoprotein parameters, inverse correlations were found between HDL2-cholesterol and fasting plasma TG levels and obesity index. Furthermore, HDL2-cholesterol were positively correlated with HDL-cholesterol. In contrast, no correlations were found with plasma TG levels and HDL3-cholesterol levels. Accordingly, this present study suggests a relationship between the metabolism of TG and HDL2-cholesterol.<br>Patients with hypertriglyceridemia, such as subjects with type IIb and type IV hyperlipoproteinemia, had significantly lower HDL-cholesterol and HDL2-cholesterol levels than healthy subjects. However, type IIa hyperlipoproteinemia was not observed in the magnitude of HDL-cholesterol depression.<br>HDL-cholesterol levels were significantly lower in patients with ischemic heart disease than in healthy subjects. When divided into HDL subfractions, both HDL2 and HDL3-cholesterol levels were significantly diminished as compared to healthy subjects.

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