Comparative study on the efficacy and safety of continuous versus twice-daily 3-hour infusion of cyclosporine A in pediatric hematopoietic stem cell transplantation

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  • NODOMI Seishiro
    Department of Pediatrics, Graduate School of Medicine, Kyoto University
  • UMEDA Katsutsugu
    Department of Pediatrics, Graduate School of Medicine, Kyoto University
  • MATSUBARA Hiroshi
    Department of Pediatrics, Graduate School of Medicine, Kyoto University
  • DAIFU Tomoo
    Department of Pediatrics, Graduate School of Medicine, Kyoto University
  • KATO Itaru
    Department of Pediatrics, Graduate School of Medicine, Kyoto University
  • HIRAMATSU Hidefumi
    Department of Pediatrics, Graduate School of Medicine, Kyoto University
  • WATANABE Ken-ichiro
    Department of Pediatrics, Graduate School of Medicine, Kyoto University
  • HEIKE Toshio
    Department of Pediatrics, Graduate School of Medicine, Kyoto University
  • ADACHI Souichi
    Human Health Sciences, Graduate School of Medicine Kyoto University

Bibliographic Information

Other Title
  • 小児造血幹細胞移植におけるシクロスポリン持続静注法と1日2回3時間静注法の有効性と安全性の比較検討
  • 臨床研究 小児造血幹細胞移植におけるシクロスポリン持続静注法と1日2回3時間静注法の有効性と安全性の比較検討
  • リンショウ ケンキュウ ショウニ ゾウケツ カン サイボウ イショク ニ オケル シクロスポリン ジゾク ジョウチュウホウ ト 1ニチ 2カイ 3ジカン ジョウチュウホウ ノ ユウコウセイ ト アンゼンセイ ノ ヒカク ケントウ

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Description

Cyclosporine (CsA) is widely used for graft-versus-host disease (GVHD) in pediatric hematopoietic stem cell transplantation (HSCT); however, the optimal schedule of its administration has not been established. We retrospectively compared the time-course of blood CsA levels and the incidence of CsA-associated adverse effects, grade II-IV acute GVHD, and chronic GVHD among 26 pediatric HSCT recipients who were receiving CsA by continuous infusion (CIF) (n=8) or by 3h infusion twice-daily (3TD) (n=18). In the 3TD group, the target level of the C3 value, which is strongly co-related with the area under the concentration-time curve, was maintained without any serious adverse effects in most patients. No significant differences were observed in the incidence of grade II-IV acute GVHD and chronic GVHD between CIF and 3TD groups. 3TD in combination with C3 monitoring enables safe and easy control of CsA blood levels and is thought to be useful for GVHD prophylaxis in pediatric HSCT.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 53 (11), 1891-1897, 2012

    The Japanese Society of Hematology

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