{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680015216640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1536/ihj.19.112"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaE1MXltVais70%3D"}},{"identifier":{"@type":"PMID","@value":"148520"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"1923099"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/1923099"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I1923099"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/ihj1960/19/1/19_1_112/_pdf"}},{"identifier":{"@type":"NAID","@value":"130000762741"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Effect of 2-Nicotinamidethyl Nitrate (SG 75) on Coronary Circulation"},{"@language":"ja-Kana","@value":"Effect of 2 Nicotinamidethyl Nitrate SG"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The effect of a new chemical agent, SG 75, on coronary blood flow of anesthetized dogs has been examined. Intravenous administrations of this agent in a dose of 10μg/Kg or over caused a significant increase in blood flow of non-constricted coronary artery. Percent increases in flow were 40 (10μg/Kg), 95 (50μg/Kg), 145 (100μg/Kg), and 195 (250μg/Kg). The increases were significantly larger than those caused by the same doses of diltiazem, verapamil, nitroglycerin, isosolbide dinitrate, and papaverine. The durations of the increase in flow were 12 (10μg/Kg), 23 (50μg/Kg), 28 (100μg/Kg), and 46 min (250μg/Kg), and they were longer than those caused by diltiazem and verapamil. A slight reduction in left ventricular tension and an increase in aortic blood flow were also observed following the administrations of SG 75 in a dose of over 50μg/Kg. A decrease in heart rate was produced with a dose of over 500μg/Kg. However, PQ interval of electrocardiogram became shorter. Intravenous administrations of SG 75 in doses of 50 and 150μg/Kg caused an increase in blood flow of the constricted coronary artery, while nitroglycerin (10 and 30μg/Kg) and nifedipine (1 and 3μg/Kg) reduced it. The results indicate that SG 75 is a potent and long-acting coronary vasodilating agent and it causes an increase in blood flow of constricted as well as non-constricted coronary artery."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658340206337","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60010419"},{"@type":"NRID","@value":"1000060010419"},{"@type":"NRID","@value":"9000003886246"},{"@type":"NRID","@value":"9000021372326"},{"@type":"NRID","@value":"9000021367633"},{"@type":"NRID","@value":"9000021263823"},{"@type":"NRID","@value":"9000022119467"},{"@type":"NRID","@value":"9000266902301"},{"@type":"NRID","@value":"9000256871139"},{"@type":"NRID","@value":"9000021370999"},{"@type":"NRID","@value":"9000021258034"},{"@type":"NRID","@value":"9000021270269"},{"@type":"NRID","@value":"9000021227070"},{"@type":"NRID","@value":"9000021227434"},{"@type":"NRID","@value":"9000021383200"},{"@type":"NRID","@value":"9000022172037"},{"@type":"NRID","@value":"9000020678648"},{"@type":"NRID","@value":"9000022431494"},{"@type":"NRID","@value":"9000020453271"},{"@type":"NRID","@value":"9000021335752"},{"@type":"NRID","@value":"9000022105852"},{"@type":"NRID","@value":"9000266902951"},{"@type":"NRID","@value":"9000256889104"},{"@type":"NRID","@value":"9000007152979"},{"@type":"NRID","@value":"9000007734559"},{"@type":"NRID","@value":"9000008318668"},{"@type":"NRID","@value":"9000021284265"},{"@type":"NRID","@value":"9000021371437"},{"@type":"NRID","@value":"9000021346305"},{"@type":"NRID","@value":"9000256496680"},{"@type":"NRID","@value":"9000007683512"},{"@type":"NRID","@value":"9000021343771"},{"@type":"NRID","@value":"9000022134691"},{"@type":"NRID","@value":"9000255847734"},{"@type":"NRID","@value":"9000266901814"},{"@type":"NRID","@value":"9000022169655"},{"@type":"NRID","@value":"9000258532912"},{"@type":"NRID","@value":"9000258532625"},{"@type":"NRID","@value":"9000020766995"},{"@type":"NRID","@value":"9000021261543"},{"@type":"NRID","@value":"9000021389171"},{"@type":"NRID","@value":"9000266901262"},{"@type":"NRID","@value":"9000256853536"},{"@type":"NRID","@value":"9000283221989"},{"@type":"NRID","@value":"9000022118226"},{"@type":"NRID","@value":"9000021289842"},{"@type":"NRID","@value":"9000021256937"},{"@type":"NRID","@value":"9000021247662"},{"@type":"NRID","@value":"9000402921582"},{"@type":"NRID","@value":"9000256847264"},{"@type":"NRID","@value":"9000256853171"},{"@type":"NRID","@value":"9000021228069"},{"@type":"NRID","@value":"9000021236457"},{"@type":"NRID","@value":"9000021220067"},{"@type":"NRID","@value":"9000021363635"},{"@type":"NRID","@value":"9000022111652"},{"@type":"NRID","@value":"9000290137319"},{"@type":"NRID","@value":"9000258532214"},{"@type":"NRID","@value":"9000008475383"},{"@type":"NRID","@value":"9000006116139"},{"@type":"NRID","@value":"9000020765750"},{"@type":"NRID","@value":"9000022104899"},{"@type":"NRID","@value":"9000021406634"},{"@type":"NRID","@value":"9000022119461"},{"@type":"NRID","@value":"9000008797223"},{"@type":"NRID","@value":"9000283221992"},{"@type":"NRID","@value":"9000003926808"},{"@type":"NRID","@value":"9000021354976"},{"@type":"NRID","@value":"9000021320806"},{"@type":"NRID","@value":"9000021260759"},{"@type":"NRID","@value":"9000021286774"},{"@type":"NRID","@value":"9000255791703"},{"@type":"NRID","@value":"9000017899824"},{"@type":"NRID","@value":"9000253229096"},{"@type":"NRID","@value":"9000021247003"},{"@type":"NRID","@value":"9000022127271"},{"@type":"NRID","@value":"9000022127248"},{"@type":"NRID","@value":"9000022144027"},{"@type":"NRID","@value":"9000255951424"},{"@type":"NRID","@value":"9000265537929"},{"@type":"NRID","@value":"9000021390650"},{"@type":"NRID","@value":"9000021328909"},{"@type":"NRID","@value":"9000021228986"},{"@type":"NRID","@value":"9000021408952"},{"@type":"NRID","@value":"9000256887288"},{"@type":"NRID","@value":"9000008068889"},{"@type":"NRID","@value":"9000003952852"},{"@type":"NRID","@value":"9000022116688"},{"@type":"NRID","@value":"9000021397118"},{"@type":"NRID","@value":"9000021258767"},{"@type":"NRID","@value":"9000021394377"},{"@type":"NRID","@value":"9000252821489"},{"@type":"NRID","@value":"9000021321861"},{"@type":"NRID","@value":"9000022140729"},{"@type":"NRID","@value":"9000256853276"},{"@type":"NRID","@value":"9000256847870"},{"@type":"NRID","@value":"9000007449665"},{"@type":"NRID","@value":"9000020713310"},{"@type":"NRID","@value":"9000006407749"},{"@type":"NRID","@value":"9000021412414"},{"@type":"NRID","@value":"9000021170774"},{"@type":"NRID","@value":"9000021382560"},{"@type":"NRID","@value":"9000022127262"}],"foaf:name":[{"@language":"en","@value":"UCHIDA Yasumi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133526678272","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80467612"},{"@type":"NRID","@value":"1000080467612"},{"@type":"NRID","@value":"9000017582758"},{"@type":"NRID","@value":"9000003952854"},{"@type":"NRID","@value":"9000021371005"},{"@type":"NRID","@value":"9000021258040"},{"@type":"NRID","@value":"9000021227082"},{"@type":"NRID","@value":"9000253218710"},{"@type":"NRID","@value":"9000004017703"},{"@type":"NRID","@value":"9000003963287"},{"@type":"NRID","@value":"9000021343779"},{"@type":"NRID","@value":"9000003984556"},{"@type":"NRID","@value":"9000021389177"},{"@type":"NRID","@value":"9000021241713"},{"@type":"NRID","@value":"9000021406638"},{"@type":"NRID","@value":"9000004087507"},{"@type":"NRID","@value":"9000021166792"},{"@type":"NRID","@value":"9000021286783"},{"@type":"NRID","@value":"9000004278925"},{"@type":"NRID","@value":"9000004313333"},{"@type":"NRID","@value":"9000003935587"},{"@type":"NRID","@value":"9000259070811"}],"foaf:name":[{"@language":"en","@value":"YOSHIMOTO 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J"},{"@language":"ja","@value":"Ｊａｐａｎｅｓｅ　Ｈｅａｒｔ　Ｊｏｕｒｎａｌ"}],"dc:publisher":[{"@language":"en","@value":"International Heart Journal Association"},{"@language":"ja","@value":"International Heart Journal刊行会"}],"prism:publicationDate":"1978","prism:volume":"19","prism:number":"1","prism:startingPage":"112","prism:endingPage":"124"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/1923099"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I1923099"},{"@id":"http://www.jstage.jst.go.jp/article/ihj1960/19/1/19_1_112/_pdf"}],"availableAt":"1978","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=SG%2075","dc:title":"SG 75"},{"@id":"https://cir.nii.ac.jp/all?q=Coronary%20blood%20flow","dc:title":"Coronary blood flow"},{"@id":"https://cir.nii.ac.jp/all?q=Coronary%20constriction","dc:title":"Coronary constriction"},{"@id":"https://cir.nii.ac.jp/all?q=ECG%20changes","dc:title":"ECG changes"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390282680081136128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008)"},{"@value":"Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008) - Digest Version -"},{"@value":"Japanese Circulation Society of Guidelines for Diagnosis and Treatment of Patients with Vasospastic Angina (Coronary Spastic Angina) (JCS2008)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680084442624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2013)"},{"@value":"Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2013) : Digest Version"},{"@value":"Guidelines for diagnosis and treatment of patients with vasospastic angina (coronary spastic angina)"},{"@value":"Guidelines for diagnosis and treatment of patients with vasospastic angina (Coronary Spastic Angina) (JCS 2013). 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