{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680021443584.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2334/josnusd.57.115"}},{"identifier":{"@type":"PMID","@value":"26062860"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/josnusd/57/2/57_115/_pdf"}},{"identifier":{"@type":"NAID","@value":"130005076031"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2016195923"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Glucose transporters, such as GLUT-1, mediate the important mechanisms involved in cellular glucose influx, allowing cells to proliferate and survive. The significance of GLUT-1 expression in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) has been less explored, and no study has investigated it in relation to verrucous carcinoma (VC). We evaluated 30 cases each of OED, OSCC, and VC, graded further on the basis of their differentiation, immunohistochemically for GLUT-1 expression, along with 10 specimens of normal oral mucosa (NOM) as controls. In OSCC, GLUT-1 expression increased with the degree of dysplasia and increasing grade (<i>P</i> < 0.001). The expression in VC was predominantly membranous and intense, resembling well differentiated OSCC. This increase of GLUT-1 expression in OSCC along with the degree of dysplasia and the histologic grade reflects the expanding glycolytic response to hypoxia. This is the first study to have revealed prominent GLUT-1 expression in VC, highlighting its inherent metabolic capacity. (J Oral Sci 57, 115-122, 2015)"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282680021443585","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000293529672"}],"foaf:name":[{"@language":"en","@value":"C. Angadi Vidya"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral Pathology and Microbiology, KLEVK Institute of Dental Sciences and Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680021443584","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000293529673"}],"foaf:name":[{"@language":"en","@value":"V. Angadi Punnya"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral Pathology and Microbiology, KLEVK Institute of Dental Sciences and Hospital"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13434934"},{"@type":"LISSN","@value":"13434934"},{"@type":"EISSN","@value":"18804926"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Oral Science"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒａｌ　Ｓｃｉｅｎｃｅ"},{"@language":"en","@value":"J Oral Sci"},{"@language":"en","@value":"Journal of Oral Science"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒａｌ　Ｓｃｉｅｎｃｅ"}],"dc:publisher":[{"@language":"en","@value":"Nihon University School of Dentistry"},{"@language":"ja","@value":"日本大学歯学部"}],"prism:publicationDate":"2015","prism:volume":"57","prism:number":"2","prism:startingPage":"115","prism:endingPage":"122"},"reviewed":"false","url":[{"@id":"https://www.jstage.jst.go.jp/article/josnusd/57/2/57_115/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2016195923"}],"availableAt":"2015","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=GLUT-1","dc:title":"GLUT-1"},{"@id":"https://cir.nii.ac.jp/all?q=oral%20epithelial%20dysplasia","dc:title":"oral epithelial dysplasia"},{"@id":"https://cir.nii.ac.jp/all?q=oral%20squamous%20cell%20carcinoma","dc:title":"oral squamous cell carcinoma"},{"@id":"https://cir.nii.ac.jp/all?q=verrucous%20carcinoma","dc:title":"verrucous carcinoma"},{"@id":"https://cir.nii.ac.jp/all?q=histologic%20differentiation","dc:title":"histologic differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=glucose%20transport","dc:title":"glucose transport"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360013168881821824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prognostic significance of hypoxia-inducible factor-1α expression in advanced pharyngeal cancer without human papillomavirus infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620556720000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Grading oral epithelial dysplasia: analysis of individual features"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570347520128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570431326720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131644418072064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Glucose metabolism changes during the development and progression of oral tongue squamous cell carcinomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519005963648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519848779648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"GLUT1 glucose transporter expression in colorectal carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994700005888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Thalidomide: features and potential significance in oral precancerous conditions and oral cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943664456704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"GLUT1 Messenger RNA and Protein Induction Relates to the Malignant Transformation of Cervical Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944466785408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Overexpression of Glut‐1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945131852800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Overexpression of GLUT-1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420324061568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of facilitative glucose transport proteins during development of squamous cell carcinomas of the head and neck"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895344036224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Correlation between glucose transporter type-1 expression and<sup>18</sup>F-FDG uptake on PET in oral cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369752641152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of Glucose Transporter-1 in Cervical Cancer and Its Precursors"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318796581888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320878318208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794148190336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparison of Myofibroblasts Expression in Oral Squamous Cell Carcinoma, Verrucous Carcinoma, High Risk Epithelial Dysplasia, Low Risk Epithelial Dysplasia and Normal Oral Mucosa"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794340207104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Coexpression of hypoxia-inducible factor-1α and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795068692864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oral cavity"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268592673152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of hexokinase II and Glut-1 in untreated human breast cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269160588928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Natural history of potentially malignant oral lesions and conditions: an overview of the literature"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2000646009"},{"@type":"CROSSREF","@value":"10.2334/josnusd.57.115"},{"@type":"PUBMED","@value":"26062860"},{"@type":"CIA","@value":"130005076031"},{"@type":"CROSSREF","@value":"10.1017/s0022215121001468_references_DOI_8RRutpUdqSygpgwOR9Sn0Yb7Fyy"},{"@type":"CROSSREF","@value":"10.3892/ol.2019.10420_references_DOI_8RRutpUdqSygpgwOR9Sn0Yb7Fyy"}]}