{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680073243136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1272/jnms.79.204"}},{"identifier":{"@type":"COI","@value":"1:STN:280:DC%2BC38jps1Oisg%3D%3D"}},{"identifier":{"@type":"PMID","@value":"22791122"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jnms/79/3/79_204/_pdf"}},{"identifier":{"@type":"NAID","@value":"130004147166"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2013156671"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Efficacy and Safety of Gemcitabine Monotherapy for Patients with Advanced Biliary Tract Cancer"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<b>Objective:</b> The aim of this study was to analyze the efficacy and feasibility of gemcitabine monotherapy in patients with unresectable advanced or recurrent biliary tract cancer (BTC).<br> <b>Methods:</b> Six patients with unresectable advanced BTC and 12 patients with recurrent BTC received gemcitabine monotherapy. Gemcitabine (800-1,000 mg/m<sup>2</sup>) was administered intravenously over 30 minutes on days 1, 8, and 15 every 28 days. Disease and toxicity were assessed once a week in all patients until the completion of gemcitabine treatment. Computed tomographic/magnetic resonance imaging studies were done every 8 weeks during chemotherapy, and every 4 weeks if progressive disease was suspected. Tumor response was determined according to the Response Evaluation Criteria in Solid Tumors. Toxicity was assessed using the National Cancer Institute Common Toxicity Criteria version 2.0. The time to progression and survival time were also calculated.<br> <b>Results:</b> In patients with unresectable BTC, the overall response rate and the median time to progression for patients with partial response or stable disease was 66.7% and 5.68 months, respectively. Clinical benefit was observed in 3 patients with stable disease (50%). The median survival time was 5.2 months. In patients with recurrent BTC, 4 patients (33%) obtained partial responses and 2 patients (17%) had stable disease. The median time to progression was 8.2 months. Six of 12 patients (50%) obtained clinical benefit. The median survival time for cancer of the intrahepatic bile duct, the extrahepatic bile duct, and the ampulla of Vater were 2.8 months, 8.5 months, and 10.7 months, respectively. No significant correlation between the survival time and the resectability of the initial procedure (R number) was detected. The survival time for patients with a performance status of 0 or 1 was significantly longer than that for patients with a performance status of 2 (<i>P</i>=<i>0.0051</i>). Neither grade 3/4 hematologic toxicity nor grade 3/4 nonhematologic toxicity was observed. No treatment-related deaths were observed.<br> <b>Conclusion:</b> Gemcitabine monotherapy may provide a more favorable prognosis in patients with advanced BTC than does best supportive care alone. Moreover, this regimen may represent a therapeutic option for the adjuvant setting in patients with BTC.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001205094101638","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256004440"},{"@type":"NRID","@value":"9000001504733"},{"@type":"NRID","@value":"9000002888522"},{"@type":"NRID","@value":"9000365533770"},{"@type":"NRID","@value":"9000323299145"},{"@type":"NRID","@value":"9000256004828"},{"@type":"NRID","@value":"9000283114787"},{"@type":"NRID","@value":"9000413567924"},{"@type":"NRID","@value":"9000255696459"},{"@type":"NRID","@value":"9000256006016"},{"@type":"NRID","@value":"9000258013848"},{"@type":"NRID","@value":"9000256005631"},{"@type":"NRID","@value":"9000256638900"},{"@type":"NRID","@value":"9000025027697"},{"@type":"NRID","@value":"9000346933434"},{"@type":"NRID","@value":"9000405657239"},{"@type":"NRID","@value":"9000405657153"},{"@type":"NRID","@value":"9000283664123"},{"@type":"NRID","@value":"9000255696431"},{"@type":"NRID","@value":"9000412550543"},{"@type":"NRID","@value":"9000411087409"},{"@type":"NRID","@value":"9000404105511"},{"@type":"NRID","@value":"9000255696067"},{"@type":"NRID","@value":"9000016659257"},{"@type":"NRID","@value":"9000256005253"},{"@type":"NRID","@value":"9000402078653"},{"@type":"NRID","@value":"9000256621181"},{"@type":"NRID","@value":"9000413888070"},{"@type":"NRID","@value":"9000256005686"},{"@type":"NRID","@value":"9000019086563"},{"@type":"NRID","@value":"9000290133897"},{"@type":"NRID","@value":"9000283558286"},{"@type":"NRID","@value":"9000256004937"},{"@type":"NRID","@value":"9000256004886"},{"@type":"NRID","@value":"9000256005696"},{"@type":"NRID","@value":"9000256004656"},{"@type":"NRID","@value":"9000283597689"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/yokkey-0805"}],"foaf:name":[{"@language":"en","@value":"Yokoyama 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