{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680081753600.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1253/circj.cj-08-1169"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/circj/73/4/73_CJ-08-1169/_pdf"}},{"identifier":{"@type":"NAID","@value":"10025928764"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2009192885"}}],"dc:title":[{"@language":"en","@value":"Endothelial Dysfunction  The First Step Toward Coronary Arteriosclerosis"},{"@value":"Endothelial dysfunction"}],"dcterms:alternative":[{"@language":"en","@value":"The First Step Toward Coronary Arteriosclerosis"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The endothelium causes relaxations of the underlying vascular smooth muscle, by releasing nitric oxide (NO). The endothelial cells also can evoke hyperpolarization of the vascular smooth muscle cells (endothelium-dependent hyperpolarizations, endothelium-derived hyperpolarizing factors-mediated responses). Endothelium-dependent relaxations involve both pertussis toxin-sensitive Gi and pertussis toxin-insensitive Gq coupling proteins. The endothelial release of NO is reduced in diabetes and hypertension. Arteries covered with regenerated endothelium lose the pertussis-toxin sensitive pathway for NO-release. This dysfunction favors vasospasm, thrombosis, penetration of macrophages, cellular growth and the inflammatory reaction leading to atherosclerosis. Endothelial cells also release endothelium-derived contracting factors (EDCF). Most endothelium-dependent contractions are mediated by vasoconstrictor prostanoids (endoperoxides and prostacyclin), which activate thromboxane-prostanoid (TP)-receptors of the underlying vascular smooth muscle cells. EDCF-mediated responses are augmented by aging, hypertension and diabetes. Thus, endothelial dysfunction is the first step toward coronary arteriosclerosis. (<i>Circ J</i> 2009; <b>73:</b> 595 - 601)<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282680081753600","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000017040332"}],"foaf:name":[{"@language":"en","@value":"Vanhoutte Paul M."}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13469843"},{"@type":"LISSN","@value":"13469843"},{"@type":"EISSN","@value":"13474820"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/13469843"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/13469843"},{"@type":"NCID","@value":"AA11591968"}],"prism:publicationName":[{"@language":"en","@value":"Circulation Journal"},{"@language":"en","@value":"Circ J"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Circulation Society"},{"@language":"ja","@value":"一般社団法人 日本循環器学会"}],"prism:publicationDate":"2009","prism:volume":"73","prism:number":"4","prism:startingPage":"595","prism:endingPage":"601"},"reviewed":"false","url":[{"@id":"http://www.jstage.jst.go.jp/article/circj/73/4/73_CJ-08-1169/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2009192885"}],"availableAt":"2009","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Arteriosclerosis","dc:title":"Arteriosclerosis"},{"@id":"https://cir.nii.ac.jp/all?q=Endothelium","dc:title":"Endothelium"},{"@id":"https://cir.nii.ac.jp/all?q=Endothelium-derived%20relaxing%20factors","dc:title":"Endothelium-derived relaxing factors"},{"@id":"https://cir.nii.ac.jp/all?q=Vasodilatation","dc:title":"Vasodilatation"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004236322521472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Erythropoietin enhances hydrogen peroxide-mediated dilatation of canine coronary collateral 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