{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680152298368.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1254/jphs.92.283"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BD3sXlvFyqt7w%3D"}},{"identifier":{"@type":"PMID","@value":"12890894"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"6614426"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/6614426"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I6614426"}},{"identifier":{"@type":"NAID","@value":"10011209806"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2003313904"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Selective Inhibition of Mammalian DNA Polymerase .ALPHA. by Vitamin D2 and D3"},{"@value":"Selective Inhibition of Mammalian DNA Polymerase α by Vitamin D2 and D3"},{"@language":"ja-Kana","@value":"Selective Inhibition of Mammalian DNA Polymerase アルファ by Vitamin D2 and D3"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"As described previously (H. Togashi et al. Biochem Pharmacol. 1998;56:583–590), the irradiated products of provitamin D<sub>2</sub> (ergosterol) inhibit the activities of eukaryotic DNA polymerases. In this report, therefore, we investigated whether vitamin D and its related compounds inhibited the activities of DNA polymerases. As expected, vitamin D<sub>2</sub> and vitamin D<sub>3</sub> were found to be selective inhibitors of mammalian DNA polymerase α (pol α) with IC<sub>50</sub> values of 123 and 96 μM, respectively. On the other hand, provitamin D<sub>2</sub>, provitamin D<sub>3</sub>, and the active form of vitamin D<sub>3</sub> such as 1α,25-dihydroxyvitamin D<sub>3</sub> could not influence any of the DNA polymerase activities. Interestingly, vitamin D<sub>3</sub>-3β-sulfate was a much stronger pol α inhibitor with an IC<sub>50</sub> value of 7.1 μM. Vitamin D<sub>2</sub>, vitamin D<sub>3</sub>, and vitamin D<sub>3</sub>-3β-sulfate could prevent the growth of NUGC-3 human gastric cancer cells with LD<sub>50</sub> values of 133, 77, and 44 μM, respectively, but provitamin D<sub>2</sub> and provitamin D<sub>3</sub> could not. The cells were halted at the G1 phase in the cell cycle by these compounds.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658489329152","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20307705"},{"@type":"NRID","@value":"1000020307705"},{"@type":"NRID","@value":"9000002280179"},{"@type":"NRID","@value":"9000021235028"},{"@type":"NRID","@value":"9000243883529"},{"@type":"NRID","@value":"9000020906804"},{"@type":"NRID","@value":"9000263042182"},{"@type":"NRID","@value":"9000262363606"},{"@type":"NRID","@value":"9000021104992"},{"@type":"NRID","@value":"9000253082257"},{"@type":"NRID","@value":"9000253182876"},{"@type":"NRID","@value":"9000010103837"},{"@type":"NRID","@value":"9000391631505"},{"@type":"NRID","@value":"9000018472730"},{"@type":"NRID","@value":"9000239192079"},{"@type":"NRID","@value":"9000253181702"},{"@type":"NRID","@value":"9000253178876"},{"@type":"NRID","@value":"9000018534875"},{"@type":"NRID","@value":"9000404537498"},{"@type":"NRID","@value":"9000253182498"},{"@type":"NRID","@value":"9000021916516"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0054411"}],"foaf:name":[{"@language":"en","@value":"Mizushina Yoshiyuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University"},{"@language":"en","@value":"High Technology Research Center, Kobe-Gakuin University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680152298370","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001030297"}],"foaf:name":[{"@language":"en","@value":"Xu Xianai"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680152298372","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001030305"}],"foaf:name":[{"@language":"en","@value":"Okano Toshio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Hygienic Sciences, Kobe Pharmaceutical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680152298369","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004255131"}],"foaf:name":[{"@language":"en","@value":"Murakami Chikako"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801198146048","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50303623"},{"@type":"NRID","@value":"1000050303623"},{"@type":"CINII_AUTHOR_ID","@value":"DA14916407"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA14916407#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA14916407"},{"@type":"NRID","@value":"9000004417544"},{"@type":"NRID","@value":"9000004152717"},{"@type":"NRID","@value":"9000021863807"},{"@type":"NRID","@value":"9000345438792"},{"@type":"NRID","@value":"9000252813354"},{"@type":"NRID","@value":"9000018722888"},{"@type":"NRID","@value":"9000253178507"},{"@type":"NRID","@value":"9000405885741"},{"@type":"NRID","@value":"9000402582413"},{"@type":"NRID","@value":"9000253178882"},{"@type":"NRID","@value":"9000254714331"},{"@type":"NRID","@value":"9000411524828"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0055993"}],"foaf:name":[{"@language":"en","@value":"Takemura Masaharu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Cancer Cell Biology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1030848083682608896","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80068254"},{"@type":"NRID","@value":"1000080068254"},{"@type":"NRID","@value":"9000021235062"},{"@type":"NRID","@value":"9000021105020"},{"@type":"NRID","@value":"9000253182879"},{"@type":"NRID","@value":"9000404537497"},{"@type":"NRID","@value":"9000242107549"},{"@type":"NRID","@value":"9000364941787"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0034531"}],"foaf:name":[{"@language":"en","@value":"Yoshida Hiromi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University"},{"@language":"en","@value":"High Technology Research Center, Kobe-Gakuin University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680152298374","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Sakaguchi Kengo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Applied Biological Science, Science University of Tokyo"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13478613"},{"@type":"EISSN","@value":"13478648"},{"@type":"NDL_BIB_ID","@value":"000003539610"},{"@type":"ISSN","@value":"13478613"},{"@type":"LISSN","@value":"13478613"},{"@type":"NCID","@value":"AA11806667"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Pharmacological Sciences"},{"@language":"en","@value":"J Pharmacol Sci"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Pharmacological Society"},{"@language":"ja","@value":"公益社団法人 日本薬理学会"}],"prism:publicationDate":"2003","prism:volume":"92","prism:number":"3","prism:startingPage":"283","prism:endingPage":"290"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/6614426"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I6614426"},{"@id":"https://search.jamas.or.jp/link/ui/2003313904"}],"availableAt":"2003","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=vitamin%20D%3Csub%3E2%3C/sub%3E%20(ergocalciferol)","dc:title":"vitamin D<sub>2</sub> (ergocalciferol)"},{"@id":"https://cir.nii.ac.jp/all?q=vitamin%20D%3Csub%3E3%3C/sub%3E%20(cholecalciferol)","dc:title":"vitamin D<sub>3</sub> (cholecalciferol)"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20polymerase%20%CE%B1","dc:title":"DNA polymerase α"},{"@id":"https://cir.nii.ac.jp/all?q=enzyme%20inhibitor","dc:title":"enzyme inhibitor"},{"@id":"https://cir.nii.ac.jp/all?q=cell%20cycle%20arrest","dc:title":"cell cycle 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Its purification and characterization."}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995658505472","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"4-hydroxy-17-methylincisterol, an inhibitor of DNA polymerase-α activity and the growth of human cancer cells in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996229949312","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Specific Association of Human Telomerase Activity with Immortal Cells and Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470266510336","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944673997056","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Cholinergic differentiation triggered by blocking cell proliferation and treatment with all-trans-retinoic acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419462206592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"[10] Purification of mammalian polymerases: DNA polymerase ε"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421291666176","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Down-regulation of Telomerase Activity Is an Early Event in the Differentiation of HL60 Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894550085120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Error-prone bypass of certain DNA lesions by the human DNA polymerase κ"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895197769728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Isolation and characterization of two mutant forms of T4 polynucleotide kinase."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368387844096","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Noncalcemic actions of 1,25-dihydroxyvitamin D3 and clinical applications"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369219515008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selective Inhibition of DNA Polymerase ε by Phosphatidylinositol"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369347178752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phenotype‐specific “tissue” transglutaminase regulation in human neuroblastoma cells in response to retinoic acid: Correlation with cell death by apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369700437888","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development."}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843364987904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Role of the Vitamin D Endocrine System in Health and Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843456848384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The molecular basis of retinoic acid action. Transcriptional regulation of tissue transglutaminase gene expression in macrophages."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204695278336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chromatin-Associated DNA Polymerase Activity in Meiotic Cells of Lily and Mouse;its Stimulation by Meiotic Helix-Destabilizing Protein"},{"@value":"Chromatin-associated DNA polymerase activity in meiotic cells of lily and mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206480333824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Specific Inhibitors of Mammalian DNA Polymerase Species"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750018057856","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Purification of mammalian polymerases : DNa polymerase ε"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699971477888","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Error-prone bypass of certain DNA lesions by the human DNA polymerase κ"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176417415680","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthetic nucleosides and nucleotides. 40. Selective inhibition of eukaryotic DNA polymerase alpha by 9-(β-D-arabinofuranosyl)-2-(p-n-butylanilino) adenine 5'-triphosphate (BuAaraATP) and its 2'-up azido analog : synthesis and enzymatic evaluations"},{"@value":"ChemInform Abstract: Synthetic Nucleosides and Nucleotides. Part 40. Selective Inhibition of Eukaryotic DNA Polymerase α by 9‐(β‐D‐Arabinofuranosyl)‐2‐(p‐n‐butylanilino)adenine 5′‐Triphosphate (BuAaraATP) and Its 2′‐Up Azido Analogue: Synthesis and Enzymatic Evaluations."}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649924900224","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Isolation and characterization of two mutant forms of T4 polynucleotide kinase"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649924901632","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Vitamin A status : relationship to immunity and the antibody response"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649924902784","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The role of the vitamin D endocrine system in health and disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649924904320","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Selective inhibition of DNA polymerase ε by phosphatidylinositol"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417124901611648","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599878323200","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Vitamin Arelated compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074855031936","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An endo-exonuclease from meiotic tissues of the basidiomycete Coprinus cinereus"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074855033088","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Phenotype-specific \"tissue\" transglutaminase regulation in human neuroblastoma cells in response to retinoic acid : correlation with cell death by apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549831742208","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"1α, 25 (OH) 2 Vitamin D3-regulated expression of the eukaryotic genome"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549831745664","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The inhibitory action of fatty acids on DNA polymerase β"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500933419392","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibition of DNA primase by sphingosine and its analogues parallels with their growth suppression of cultured human leukemic cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924715297280","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chromatin-associated DNA polymerase activity in meiotic cells of lily and mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924715298432","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The molecular basis of retinoic acid action : transcriptional regulation of tissue transglutaminase gene expression in macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668926519360000","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A novel DNA polymerase I from a higher plant. rice (Oryza sativa L.)"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399692006144","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The metabolism of vitamin D3 in the chick"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399692010880","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibitory effects of 9-β-D-xylofuranosyladenine 5'-triphosphate on DNA-dependent RNA polymerase I and II from cherry salmon (Oncorhynchus masou)"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0022929817"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I6614426"},{"@type":"CROSSREF","@value":"10.1254/jphs.92.283"},{"@type":"PUBMED","@value":"12890894"},{"@type":"CIA","@value":"10011209806"},{"@type":"OPENAIRE","@value":"doi_dedup___::66bdfa2f8aba03507f9abd40a8e6b941"}]}