{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680153175296.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1254/jphs.93.289"}},{"identifier":{"@type":"PMID","@value":"14646246"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"6757891"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/6757891"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I6757891"}},{"identifier":{"@type":"NAID","@value":"10012544997"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2004101839"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Effects of KRN4884, a Novel K+ Channel Opener, on Ionic Currents in Rabbit Femoral Arterial Myocytes"},{"@value":"Effects of KRN4884, a Novel K〔+〕 Channel Opener, on Ionic Currents in Rabbit Femoral Arterial Myocytes"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Effects of KRN4884 (5-amino-<i>N</i>-[2-(2-chlorophenyl)ethyl]-<i>N'</i>-cyano-3-pyridinecarboxamidine), a novel K<sup>+</sup> channel opener, on ionic currents were examined in rabbit femoral arterial myocytes (RFAMs). Under whole-cell clamp conditions where cells were superfused with 5.9 mM K<sup>+</sup> bathing solution, KRN4884 elicited an outward current at −30 mV. KRN4884-induced current had a reversal potential of −78 mV and was abolished by application of glibenclamide (glib). KRN4884 was approximately 43 times more potent than levcromakalim in activating an ATP-sensitive K<sup>+</sup> current (I<sub>K-ATP</sub>). On the other hand, KRN4884 affected neither voltage-dependent Ca<sup>2+</sup> nor delayed rectifier K<sup>+</sup> channel currents. In the inside-out patch clamp configuration where cells were superfused with the symmetrical 140 mM K<sup>+</sup> solution, KRN4884 activated 47 pS K<sup>+</sup> channels in the presence of adenosine diphosphate. Similar 47 pS K<sup>+</sup> channels, which were reversibly inhibited by glib, were recorded under outside-out patch conditions. Using RT-PCR analysis, we found that inward rectifier K channel 6.1 (Kir6.1) and sulfonylurea 2B (SUR2B) transcripts were predominantly expressed in rabbit femoral artery. These results indicate that KRN4884 potently activates I<sub>K-ATP</sub> in RFAMs. The KRN4884-sensitive 47 pS K<sup>+</sup> channel activity underlying I<sub>K-ATP</sub> is a vascular type K<sub>ATP</sub> channel consisting of Kir6.1 and SUR2B and has similar characteristics to those of ATP-sensitive K<sup>+</sup> channels activated by K<sup>+</sup> channel openers in other types of smooth muscles.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326206931968","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20254310"},{"@type":"NRID","@value":"1000020254310"},{"@type":"NRID","@value":"9000282423932"},{"@type":"NRID","@value":"9000021281351"},{"@type":"NRID","@value":"9000347067011"},{"@type":"NRID","@value":"9000021228422"},{"@type":"NRID","@value":"9000410165556"},{"@type":"NRID","@value":"9000241750767"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0201069"}],"foaf:name":[{"@language":"en","@value":"Muraki Katsuhiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680153175299","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001191299"}],"foaf:name":[{"@language":"en","@value":"Sasaoka Akiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801200366976","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70275147"},{"@type":"NRID","@value":"1000070275147"},{"@type":"NRID","@value":"9000020308272"},{"@type":"NRID","@value":"9000020129070"},{"@type":"NRID","@value":"9000014195143"},{"@type":"NRID","@value":"9000004534278"},{"@type":"NRID","@value":"9000014195125"},{"@type":"NRID","@value":"9000410165352"},{"@type":"NRID","@value":"9000021311165"},{"@type":"NRID","@value":"9000404317435"},{"@type":"NRID","@value":"9000257782592"},{"@type":"NRID","@value":"9000397687716"},{"@type":"NRID","@value":"9000365543075"},{"@type":"NRID","@value":"9000021292162"},{"@type":"NRID","@value":"9000317149994"},{"@type":"NRID","@value":"9000021228428"},{"@type":"NRID","@value":"9000242073737"},{"@type":"NRID","@value":"9000021324039"},{"@type":"NRID","@value":"9000021800669"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/crescendo"}],"foaf:name":[{"@language":"en","@value":"Ohya Susumu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680153175300","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Watanabe Minoru"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326233459968","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60117794"},{"@type":"NRID","@value":"1000060117794"},{"@type":"NRID","@value":"9000020308291"},{"@type":"NRID","@value":"9000347074666"},{"@type":"NRID","@value":"9000409501822"},{"@type":"NRID","@value":"9000397688596"},{"@type":"NRID","@value":"9000020129076"},{"@type":"NRID","@value":"9000014195149"},{"@type":"NRID","@value":"9000021987967"},{"@type":"NRID","@value":"9000347068628"},{"@type":"NRID","@value":"9000014195132"},{"@type":"NRID","@value":"9000399841000"},{"@type":"NRID","@value":"9000021337363"},{"@type":"NRID","@value":"9000347074640"},{"@type":"NRID","@value":"9000257821680"},{"@type":"NRID","@value":"9000021281340"},{"@type":"NRID","@value":"9000007062077"},{"@type":"NRID","@value":"9000022047505"},{"@type":"NRID","@value":"9000021311192"},{"@type":"NRID","@value":"9000347067013"},{"@type":"NRID","@value":"9000021987973"},{"@type":"NRID","@value":"9000391399714"},{"@type":"NRID","@value":"9000347074268"},{"@type":"NRID","@value":"9000257782594"},{"@type":"NRID","@value":"9000019157244"},{"@type":"NRID","@value":"9000019157687"},{"@type":"NRID","@value":"9000022052561"},{"@type":"NRID","@value":"9000022004943"},{"@type":"NRID","@value":"9000365543078"},{"@type":"NRID","@value":"9000021292230"},{"@type":"NRID","@value":"9000021228451"},{"@type":"NRID","@value":"9000022487286"},{"@type":"NRID","@value":"9000242073739"},{"@type":"NRID","@value":"9000022016248"},{"@type":"NRID","@value":"9000021324049"},{"@type":"NRID","@value":"9000021800691"},{"@type":"NRID","@value":"9000392135995"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/IY1952"}],"foaf:name":[{"@language":"en","@value":"Imaizumi Yuji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13478613"},{"@type":"EISSN","@value":"13478648"},{"@type":"NDL_BIB_ID","@value":"000003539610"},{"@type":"ISSN","@value":"13478613"},{"@type":"LISSN","@value":"13478613"},{"@type":"NCID","@value":"AA11806667"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Pharmacological Sciences"},{"@language":"en","@value":"J Pharmacol Sci"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Pharmacological Society"},{"@language":"ja","@value":"公益社団法人 日本薬理学会"}],"prism:publicationDate":"2003","prism:volume":"93","prism:number":"3","prism:startingPage":"289","prism:endingPage":"298"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/6757891"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I6757891"},{"@id":"https://search.jamas.or.jp/link/ui/2004101839"}],"availableAt":"2003","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=KRN4884","dc:title":"KRN4884"},{"@id":"https://cir.nii.ac.jp/all?q=ATP-sensitive%20K%3Csup%3E+%3C/sup%3E%20channel","dc:title":"ATP-sensitive K<sup>+</sup> channel"},{"@id":"https://cir.nii.ac.jp/all?q=femoral%20artery","dc:title":"femoral artery"},{"@id":"https://cir.nii.ac.jp/all?q=K%3Csup%3E+%3C/sup%3E%20channel%20opener","dc:title":"K<sup>+</sup> channel opener"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256790958848","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15590064"},{"@type":"JGN","@value":"JP15590064"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15590064/"}],"notation":[{"@language":"ja","@value":"脂質メディエーター受容体の発現調節による脈管組織の分化・再生制御"},{"@language":"en","@value":"Regulation of differentiation and reproduction of vascular organs by Edg receptor expression"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360292618890451328","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Molecular aspects of ATP-sensitive K+ channels in the cardiovascular system and K+ channel openers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619599307776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Molecular Composition of KATP Channels in Human Pulmonary Artery Smooth Muscle Cells and Their Modulation by Growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620842205312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea‐sensitive but ATP‐insensitive K+ channel."}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093993530880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intracellular ATP can regulate afferent arteriolar tone via ATP-sensitive K+ channels in the rabbit."}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094578127104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ATP-sensitive and inwardly rectifying potassium channels in smooth muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095505180160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Two types of ATP‐sensitive potassium channels in rat portal vein smooth muscle cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570019874176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Single channel and whole‐cell K‐currents evoked by levcromakalim in smooth muscle cells from the rabbit portal vein"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043888044288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"K channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519591840640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Guanosine diphosphate activates an adenosine 5'‐triphosphate‐sensitive K+ channel in the rabbit portal vein."}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469030294144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Is there a Therapeutic Future for ‘Potassium Channel Openers’?"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469893748224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical relevance of ATP-dependent potassium channels"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470060095616","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Effects of KRN2391 on ionic currents in rabbit femoral arterial myocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945216601088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of the K+ Channel Opener KRN4884 on the Cardiovascular Metabolic Syndrome Model in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419833195136","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Potentiation by nitric oxide of the ATP‐sensitive K<sup>+</sup> current induced by K<sup>+</sup> channel openers in guinea‐pig ventricular cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421348725504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"KRN4884, a Novel K Channel Opener: Antihypertensive Effects in Conscious Renal Hypertensive Dogs"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368638677120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Physiological roles and properties of potassium channels in arterial smooth muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368755311616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cromakalim and lemakalim activate Ca2+-dependent K+ channels in canine colon"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370576287232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843800894720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of the potassium channel openers KRN4884 and levcromakalim on the contraction of rat aorta induced by A23187, compared with nifedipine"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844191302144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of potassium channel opener KRN4884 on human conduit arteries used as coronary bypass grafts"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793811117696","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Functional Roles of Cardiac and Vascular ATP-Sensitive Potassium Channels Clarified by Kir6.2-Knockout Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793927705216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hyperpolarizing Vasodilators Activate ATP-sensitive K\n            <sup>+</sup>\n            Channels in Arterial Smooth Muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794493511808","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Structure-activity relationship of a novel K+ channel opener, KRN4884, and related compounds in porcine coronary artery"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795501764480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Extracellular ATP signaling and P2X nucleotide receptors  in monolayers of primary human vascular endothelial cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795645078272","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268670226432","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Intracellular nucleotide‐mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271235984896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Smooth muscle K+ channel openers; their pharmacology and clinical potential"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204772748544","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Ｋ｀＋´チャネル開口薬―基礎と臨床　　３．　　血管に対するＫ｀＋´チャネル開口薬の作用"},{"@language":"en","@value":"<I>Effects of K<SUP>+</SUP> channel openers on vasculature </I>"}]},{"@id":"https://cir.nii.ac.jp/crid/1390009142391155968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Reciprocal Relationship between Ca<sup>2+</sup> Signaling and Ca<sup>2+</sup>-Gated Ion Channels as a Potential Target for Drug Discovery"},{"@value":"Reciprocal Relationship between Ca²⁺ Signaling and Ca²⁺-Gated Ion Channels as a Potential Target for Drug Discovery"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679261341312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ca2+-Images of Smooth Muscle Cells and Endothelial Cells in One Confocal Plane in Femoral Artery Segments of the Rat."},{"@value":"Ca〔2+〕-Images of Smooth Muscle Cells and Endothelial Cells in One Confocal Plane in Femoral Artery Segments of the Rat"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679262700544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mechanisms Underlying the Activation of Large Conductance Ca2+-Activated K+ Channels by Nordihydroguaiaretic Acid."},{"@value":"Mechanisms Underlying the Activation of Large Conductance Ca2+-Activatad K+ Channels by Nordihydroguaiaretic Acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750198518528","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical relevance of ATP-dependent potassium channels"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291224995123200","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ca^<2+> -images of smooth muscle cells and endothelial cells in one confocal plane in femoral artery segments of the rat"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225175228288","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K^+ channel in the rabbit portal vein"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225175229440","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of potassium channel opener KRN4884 on human conduit arteries used as coronary bypass grafts"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225175230848","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"K channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175128652928","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K^+ channel"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417124348489344","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Physiological roles and properties of potassium channels in arterial smooth muscle."}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125082069888","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cloning of rabbit kir6.1, SUR2A, and SUR2B : possible candidates for a renal K_ATP channel"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125082070784","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cromakalim and lemakalim activate Ca^<2+>-dependent K^+ channels in canine colon"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126625225216","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hyperpolarizing vasodilators activate ATP-sensitive K^+ channels in arterial smooth muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075035493248","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Single channel and whole-cell K-currents evoked by levcromakalim in smooth muscle cells from the rabbit portal vein"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075035495040","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mechanisms underlying the activation of large conductance Ca^<2+>-activated K^+ channels by nordihydroguaiaretic acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549871407616","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550012203136","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Intracellular ATP can regulate afferent arteriolar tone via ATP-sensitive K^+ channels in the rabbit"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550012204288","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Activation of cardiac ATP-sensitive K^+ channels by KRN4884, a novel K^+ channel opener"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550012205440","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Smooth muscle K^+ channel openers; their pharmacology and clinical 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