Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain

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  • Kawada Koichi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Japan
  • Kaneko Masayuki
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Japan
  • Nomura Yasuyuki
    Laboratory of Pharmacotherapeutics, Yokohama College of Pharmacy, Japan
  • Mimori Seisuke
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Japan
  • Hamana Hiroshi
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Japan
  • Ogita Kiyokazu
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
  • Murayama Toshihiko
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
  • Fujino Hiromichi
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
  • Okuma Yasunobu
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Japan

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Neural stem/progenitor cells (NSCs) reside in the subventricular zone (SVZ) and subgranular zone of the hippocampal dentate gyrus in adult mammals. The ubiquitin ligase HRD1 is associated with degradation of amyloid precursor protein and believed to be specifically expressed in neurons and not in astrocytes. We investigated expression of HRD1 using immunohistochemistry and found colocalization of HRD1 with the NSC marker protein nestin and glial fibrillary acidic protein in the NSCs of the SVZ (the SVZ astrocytes) but not in the hippocampus. In the hippocampal dentate gyrus, HRD1 is localized in the nucleus of nestin-positive cells.

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