{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680156396160.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1254/jphs.08r31fm"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BD1MXhvFWksg%3D%3D"}},{"identifier":{"@type":"PMID","@value":"19098387"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"9751783"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/9751783"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I9751783"}},{"identifier":{"@type":"NAID","@value":"10025732518"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2009144976"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Basic and Translational Research on Proteinase-Activated Receptors: Implication of Proteinase/Proteinase-Activated Receptor in Gastrointestinal Inflammation"},{"@value":"Implication of proteinase/proteinase-activated receptor in gastrointestinal inflammation"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Recently, the role of serine proteinases in the pathogenesis of inflammation and autoimmune diseases via interaction with the proteinase-activated receptor (PAR) has attracted attention. Activation of PAR has a pro-inflammatory effect through the overproduction of inflammatory cytokines such as interleukin (IL)-6 and IL-8. PAR<sub>2</sub> activation in human esophageal epithelial cells by trypsin induces NFκB– and AP-1–dependent IL-8 production in association with activation of p38 MAPK and ERK1/2, suggesting that esophageal inflammation may be induced by PAR<sub>2</sub> activation via reflux of trypsin. It has been also proposed that <i>Helicobacter pylori</i> (<i>H. pylori</i>) induces PAR expression in the gastric epithelial cells and <i>H. pylori</i>–derived serine proteinase promotes IL-8 production via PAR in the epithelial cells. In addition, an increase of PAR-dependent IL-8 production has been observed in <i>H. pylori</i>–infected human gastric mucosa, suggesting an important role for PAR<sub>2</sub> in the modulation of gastric inflammation associated with <i>H. pylori</i>. Recent studies have strongly indicated that tryptase and PAR are implicated in the pathogenesis of inflammatory bowel disease and experimental colitis. We demonstrated that anti-tryptase therapy may become a new therapeutic strategy in human ulcerative colitis. Thus, the role of PAR in the gastrointestinal tract has been gradually clarified, but further investigations are needed because the receptor has a variety of functions.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282680156396161","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000016808995"}],"foaf:name":[{"@language":"en","@value":"Yoshida Norimasa"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology, Japanese Red Cross Kyoto Daiichi Hospital, Japan"},{"@language":"en","@value":"Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680156396160","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000016808997"}],"foaf:name":[{"@language":"en","@value":"Yoshikawa Toshikazu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13478613"},{"@type":"EISSN","@value":"13478648"},{"@type":"NDL_BIB_ID","@value":"000003539610"},{"@type":"ISSN","@value":"13478613"},{"@type":"LISSN","@value":"13478613"},{"@type":"NCID","@value":"AA11806667"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Pharmacological Sciences"},{"@language":"en","@value":"J Pharmacol Sci"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Pharmacological Society"},{"@language":"ja","@value":"公益社団法人 日本薬理学会"}],"prism:publicationDate":"2008","prism:volume":"108","prism:number":"4","prism:startingPage":"415","prism:endingPage":"421"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/9751783"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I9751783"},{"@id":"https://search.jamas.or.jp/link/ui/2009144976"}],"availableAt":"2008","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=proteinase-activated%20receptor%20(PAR)","dc:title":"proteinase-activated receptor (PAR)"},{"@id":"https://cir.nii.ac.jp/all?q=esophagitis","dc:title":"esophagitis"},{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3EHelicobacter%20pylori%3C/i%3E","dc:title":"<i>Helicobacter pylori</i>"},{"@id":"https://cir.nii.ac.jp/all?q=colitis","dc:title":"colitis"},{"@id":"https://cir.nii.ac.jp/all?q=proteinase%20inhibitor","dc:title":"proteinase inhibitor"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144574386688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gastrointestinal functions of proteinase-activated receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144915763712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Temperature-Dependent Switch from Chaperone to Protease in a Widely Conserved Heat Shock Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146546780800","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"<i>Helicobacter pylori</i>\n            Virulence and Genetic Geography"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870028419968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase: selective enhancement of eosinophil recruitment by 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