Overview of non-neuronal cholinergic systems and their biological significance
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- Kawashima Koichiro
- Department of Pharmacology, Kyoritsu College of Pharmacy, Japan
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- Fujii Takeshi
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts, Japan
書誌事項
- タイトル別名
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- Basic and Clinical Aspects of Non-neuronal Acetylcholine: <br>Overview of Non-neuronal Cholinergic Systems and Their Biological Significance
- Basic and Clinical Aspects of Non-neuronal Acetylcholine: Overview of Non-neuronal Cholinergic Systems and Their Biological Significance
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説明
Acetylcholine (ACh) is a phylogenetically ancient molecule involved in cell-to-cell signaling in almost all life-forms on earth. Cholinergic components, including ACh, choline acetyltransferase, acetylcholinesterase, and muscarinic and nicotinic ACh receptors (mAChRs and nAChRs, respectively) have been identified in numerous non-neuronal cells and tissues, including keratinocytes, cancer cells, immune cells, urinary bladder, airway epithelial cells, vascular endothelial cells, and reproductive organs, among many others. Stimulation of the mAChRs and nAChRs elicits cell-specific functional and biochemical effects. These findings support the notion that non-neuronal cholinergic systems are expressed in certain cells and tissues and are involved in the regulation of their function and that cholinergic dysfunction is related to the pathophysiology of certain diseases. They also provide clues for development of drugs with novel mechanisms of action.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 106 (2), 167-173, 2008
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680157699584
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- NII論文ID
- 10024317913
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BD1cXivFeit78%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 9395730
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- PubMed
- 18285657
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可