{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680166041472.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11340/skinresearch.13.4"}},{"identifier":{"@type":"NAID","@value":"130005078470"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2015217225"}}],"dc:title":[{"@language":"ja","@value":"ステロイド外用薬をどう使うか？"},{"@language":"en","@value":"Treatment strategy of atopic dermatitis: How to use topical corticosteroid"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Topical corticosteroid is well known as the most effective topical anti-inflammatory agents for atopic dermatitis at this time. However considerable numbers of patients are suffering from persistent refractory severe dermatitis as a result of inappropriate topical corticosteroid treatment. In such cases there seems to be several pitfalls that prevent physicians to reach the treatment goal such as insufficient comprehension of significance of anti-inflammatory effect, misevaluation of treatment outcome or ignorance of patient's low adherence. To solve those problems topical corticosteroid treatment strategy with conscious of time course to reach the goal was proposed. It is accurate proactive treatment combined with monitoring serum biomarker thymus and activation-regulated chemokine (TARC). This strategy is composed of remission induction followed by control of subclinical inflammation with tapering of topical application frequency. In the treatment schedule of atopic dermatitis physicians should recognize the two-step strategic goal. First step is to induce and maintain remission with anti-inflammatory agent; second step is the final goal of long term remission with minimal anti-inflammatory agent.Skin Research, Suppl. 21:4-10, 2014"},{"@language":"ja","@value":"アトピー性皮膚炎（AD）の抗炎症薬剤として，現在ステロイド外用薬（TCS）は最も効果の明らかな薬剤である。だがTCSが適切に使われず遷延化，重症化している患者は少なくない。ADの治療ゴールを確認し，到達の過程でのTCSの意義とアウトカム評価，アドヒアランス等実施上の問題をあげ，それらを解決してゴールに到達する時間軸を意識した外用方法を示した。long term controlの方法として近年エビデンスが確認されているproactive療法に，血清TARCを客観的病勢評価として組み合わせた，寛解導入，維持，漸減を明確に意識した外用戦略である。初めは薬剤を使って症状がない状態を維持し，その後最小限の薬剤で症状がない状態へと患者を導くことを意識すべきである。（皮膚の科学，増21:4-10, 2014）"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001205188305027","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283574686"}],"foaf:name":[{"@language":"ja","@value":"片岡 葉子"},{"@language":"en","@value":"KATAOKA Yoko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Dermatology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases"},{"@language":"ja","@value":"大阪府立呼吸器・アレルギー医療センター皮膚科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13471813"},{"@type":"EISSN","@value":"18839614"}],"prism:publicationName":[{"@language":"en","@value":"Hifu no kagaku"},{"@language":"ja","@value":"皮膚の科学"},{"@language":"en","@value":"Hifu no kagaku"},{"@language":"en","@value":"SKIN RESEARCH"},{"@language":"ja","@value":"皮膚の科学"}],"dc:publisher":[{"@language":"en","@value":"Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association"},{"@language":"ja","@value":"日本皮膚科学会大阪地方会・日本皮膚科学会京滋地方会"}],"prism:publicationDate":"2014","prism:volume":"13","prism:number":"Suppl.21","prism:startingPage":"4","prism:endingPage":"10"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/2015217225"}],"availableAt":"2014","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A2%E3%83%88%E3%83%94%E3%83%BC%E6%80%A7%E7%9A%AE%E8%86%9A%E7%82%8E","dc:title":"アトピー性皮膚炎"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%B9%E3%83%86%E3%83%AD%E3%82%A4%E3%83%89%E5%A4%96%E7%94%A8%E8%96%AC","dc:title":"ステロイド外用薬"},{"@id":"https://cir.nii.ac.jp/all?q=Proactive%E7%99%82%E6%B3%95","dc:title":"Proactive療法"},{"@id":"https://cir.nii.ac.jp/all?q=TARC","dc:title":"TARC"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%AF%9B%E8%A7%A3%E7%B6%AD%E6%8C%81","dc:title":"寛解維持"},{"@id":"https://cir.nii.ac.jp/all?q=atopic%20dermatitis","dc:title":"atopic dermatitis"},{"@id":"https://cir.nii.ac.jp/all?q=topical%20corticosteroid","dc:title":"topical corticosteroid"},{"@id":"https://cir.nii.ac.jp/all?q=proactive%20treatment","dc:title":"proactive treatment"},{"@id":"https://cir.nii.ac.jp/all?q=TARC","dc:title":"TARC"},{"@id":"https://cir.nii.ac.jp/all?q=remission%20maintenance","dc:title":"remission maintenance"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2000655068"},{"@type":"CIA","@value":"130005078470"}]}