{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680173489408.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.18891/jjfcs.12.2_63"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"7820564"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/7820564"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I7820564"}},{"identifier":{"@type":"NAID","@value":"110007367313"}}],"dc:title":[{"@language":"ja","@value":"ガラナ抽出物のF344/DuCrjラットを用いた13週間経口投与毒性試験"},{"@language":"en","@value":"13-Week Oral Toxicity of Guarana Extract in F344/DuCrj Rats"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The potential toxicity of Guarana extract was investigated in groups of 10 F344 rats of each sex given solid diet containing the compound at 0.625, 1.25, 2.5 or 5.0% for 13 weeks. No lexicologically significant treatment-related effects were noted regarding clinical signs, survival rate, body weights, food consumption, food efficiency, urinalyses, hematology, blood biochemistry, ophthalmology and gross pathology. Parameters that showed lexicologically significant alterations with Guarana extract treatment included the following : increased water consumption in the 2.5% or more females ; increased salivary gland weights in the 5.0% males and females; increased incidences of an acinar cell hypertrophy in the submandibular and sublingual glands of the 2.5% or more males and females. The present results indicated that the no observed adverse effect level for 13 weeks dietary treatment to be 1.25% (male : 940 mg/kg/day, female: 949 mg/kg/day) being in accord with 35 mg/kg/day of caffeine in both sexes."},{"@language":"ja","@value":"F344/DuCrj(Fischer)系ラットを用いて、ガラナ抽出物の13週間反復投与毒性試験を飼料中濃度0, 0.625, 1.25, 2.5および5.0%で実施した。臨床症状、体重、摂餌量、食餌効率、尿検査、血液検査、血液生化学的検査、眼科学的検査および肉眼的病理検査ではガラナ抽出物投与の影響を認めなかった。ガラナ抽出物投与による毒性学的意義のある変化は以下の通りであった。1.摂水量では、雌の2.5%以上の投与群において投与期間を通じて高値を示した。2.唾液腺では相対重量が雌雄の5.0%群で増加を認めた。3.病理組織学的検査では、顎下腺および舌下腺腺房細胞の肥大の発生を雌雄の2.5%以上の投与群で認めた。以上の結果より、ガラナ抽出物の13週間反復経□投与により、上記変化を認めなかった1.25%投与群(雄で940mg/kg/day、雌で949ms/ke/day)(caffeine 35mg/kg/dayに相当)を無毒性量(NOAEL)と判断した。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204416246529","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000003098246"}],"foaf:name":[{"@language":"ja","@value":"玉野 静光"},{"@language":"en","@value":"Tamano Seiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"DIMS Institute of Medical Science, Inc."},{"@language":"ja","@value":"(株)DIMS医科学研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680171883142","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000014609837"}],"foaf:name":[{"@language":"ja","@value":"河部 真弓"},{"@language":"en","@value":"Kawabe Mayumi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"DIMS Institute of Medical Science, Inc."},{"@language":"ja","@value":"(株)DIMS医科学研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680172016002","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000014610062"}],"foaf:name":[{"@language":"ja","@value":"畑原 百合子"},{"@language":"en","@value":"Hatahara Yuriko"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"(株)DIMS医科学研究所"},{"@language":"en","@value":"DIMS Institute of Medical Science, Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680171928962","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000014609836"}],"foaf:name":[{"@language":"ja","@value":"佐野 真土"},{"@language":"en","@value":"Sano Masashi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"DIMS Institute of Medical Science, Inc."},{"@language":"ja","@value":"(株)DIMS医科学研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204415731331","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000003098113"}],"foaf:name":[{"@language":"ja","@value":"萩原 昭裕"},{"@language":"en","@value":"Hagiwara Akihiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"DIMS Institute of Medical Science, Inc."},{"@language":"ja","@value":"(株)DIMS医科学研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680173489415","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000014610274"}],"foaf:name":[{"@language":"ja","@value":"福本 隆行"},{"@language":"en","@value":"Fukumoto Takayuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"San-Ei Gen F.F.I., Inc."},{"@language":"ja","@value":"三栄源エフ・エフ・アイ株式会社"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204328568834","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000002271002"},{"@type":"NRID","@value":"9000392639016"}],"foaf:name":[{"@language":"ja","@value":"中村 幹雄"},{"@language":"en","@value":"Nakamura Mikio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"San-Ei Gen F.F.I., Inc."},{"@language":"ja","@value":"三栄源エフ・エフ・アイ株式会社"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680173489410","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"白井 智之"},{"@language":"en","@value":"Shirai Tomoyuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Nagoya City University Graduate School of Medical Sciences Department of Experimental Pathology and Tumor Biology"},{"@language":"ja","@value":"名古屋市立大学大学院医学研究科実験病態病理学"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13412094"},{"@type":"EISSN","@value":"21896445"},{"@type":"NDL_BIB_ID","@value":"000000095610"},{"@type":"ISSN","@value":"13412094"},{"@type":"LISSN","@value":"13412094"},{"@type":"NCID","@value":"AA11666400"}],"prism:publicationName":[{"@language":"en","@value":"Japanese Journal of Food Chemistry and Safety"},{"@language":"ja","@value":"日本食品化学学会誌"},{"@language":"en","@value":"Jpn. J. Food Chem. Safety"},{"@language":"ja","@value":"日食化誌"},{"@language":"en","@value":"Jpn. J. Food Chem."}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Food Chemistry"},{"@language":"ja","@value":"日本食品化学学会"}],"prism:publicationDate":"2005","prism:volume":"12","prism:number":"2","prism:startingPage":"63","prism:endingPage":"70"},"url":[{"@id":"http://id.ndl.go.jp/bib/7820564"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I7820564"}],"availableAt":"2005","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E4%BA%9C%E6%85%A2%E6%80%A7%E6%AF%92%E6%80%A7%E8%A9%A6%E9%A8%93","dc:title":"亜慢性毒性試験"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%AC%E3%83%A9%E3%83%8A%E6%8A%BD%E5%87%BA%E7%89%A9","dc:title":"ガラナ抽出物"},{"@id":"https://cir.nii.ac.jp/all?q=F344%E3%83%A9%E3%83%83%E3%83%88","dc:title":"F344ラット"},{"@id":"https://cir.nii.ac.jp/all?q=Subchronic%20toxicity","dc:title":"Subchronic toxicity"},{"@id":"https://cir.nii.ac.jp/all?q=Guarana%20extract","dc:title":"Guarana extract"},{"@id":"https://cir.nii.ac.jp/all?q=F344%20rats","dc:title":"F344 rats"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390282679600237568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Guarana on Exercise in Normal and Epinephrine-Induced Glycogenolytic Mice."},{"@language":"ja-Kana","@value":"Effect of Guarana on Exercise in Normal"}]},{"@id":"https://cir.nii.ac.jp/crid/1520853835538579584","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Long-Term Study on the Effect of Caffeine in Wistar Rats"},{"@language":"ja-Kana","@value":"Long Term Study on the Effect of Caffei"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225949039104","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A novel property of an aqueous guarana extract (Paullinia cupana) : inhibition of platelet aggregation in vitro and in 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