{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680187280640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1584/jpestics.30.228"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"10877625"}},{"identifier":{"@type":"NAID","@value":"110001788827"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/digimeta/10877625"}},{"identifier":{"@type":"URI","@value":"https://dl.ndl.go.jp/pid/10877625"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/jpestics/30/3/30_3_228/_pdf"}},{"identifier":{"@type":"URI","@value":"http://dl.ndl.go.jp/info:ndljp/pid/10877625"}}],"dc:title":[{"@language":"en","@value":"Mode of Action of Nonsteroidal Ecdysone Agonists, Diacylhydrazine Analogs"},{"@value":"Mode of Action of Nonsteroidal Ecdysone Agonists, Diacylhydrazine Analogs(Society Awards 2005)"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The binding affinity of insect molting hormone agonists, <i>N</i>-<i>tert</i>-butyl-<i>N</i>,<i>N</i>′-diacylhydrazine (DAH) analogs, against the molting hormone receptor proteins (EcR/USP) was measured. For the lepidopteran <i>Chilo suppressalis</i>, the receptor-binding activity of DAH analogs correlated linearly with their molting hormonal activity (<i>in vitro</i>) and insecticidal activity (<i>in vivo</i>). The binding activity of DAH analogs of <i>C. suppressalis</i> EcR/USP was higher than that of the dipteran <i>Drosophila melanogaster</i> EcR/USP. The binding activity of EcR/USP changed little when USP was exchanged between <i>C. suppressalis</i> and <i>D. melanogaster</i>. These results suggest that the selective toxicity of DAH analogs toward Lepidoptera is caused by the difference in the structure of EcR, not by that of USP. © Pesticide Science Society of Japan"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801202991232","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90509134"},{"@type":"NRID","@value":"1000090509134"},{"@type":"NRID","@value":"9000003008926"},{"@type":"NRID","@value":"9000411521480"},{"@type":"NRID","@value":"9000302391438"},{"@type":"NRID","@value":"9000257813703"},{"@type":"NRID","@value":"9000411521488"},{"@type":"NRID","@value":"9000411566950"},{"@type":"NRID","@value":"9000258328993"},{"@type":"NRID","@value":"9000257813457"},{"@type":"NRID","@value":"9000003075130"},{"@type":"NRID","@value":"9000392826666"},{"@type":"NRID","@value":"9000241877569"},{"@type":"NRID","@value":"9000403032246"},{"@type":"NRID","@value":"9000283623201"},{"@type":"NRID","@value":"9000001836438"},{"@type":"NRID","@value":"9000405346574"},{"@type":"NRID","@value":"9000257813243"},{"@type":"NRID","@value":"9000257812968"},{"@type":"NRID","@value":"9000411521496"},{"@type":"NRID","@value":"9000362202637"},{"@type":"NRID","@value":"9000356652122"},{"@type":"NRID","@value":"9000265247376"},{"@type":"NRID","@value":"9000411521481"},{"@type":"NRID","@value":"9000411521474"},{"@type":"NRID","@value":"9000256915121"},{"@type":"NRID","@value":"9000356478294"},{"@type":"NRID","@value":"9000281375556"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0066378"}],"foaf:name":[{"@language":"en","@value":"Minakuchi Chieka"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Biology, University of Washington"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1348589X"},{"@type":"EISSN","@value":"13490923"},{"@type":"CODEN","@value":"JPSTCF"},{"@type":"NCID","@value":"AA11818622"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Pesticide Science"},{"@language":"ja","@value":"日本農薬学会誌（Ｊｏｕｒｎａｌ　ｏｆ　Ｐｅｓｔｉｃｉｄｅ　Ｓｃｉｅｎｃｅ）"},{"@language":"en","@value":"J. Pestic. Sci."},{"@language":"en","@value":"Journal of Pesticide Science"},{"@language":"ja","@value":"日本農薬学会誌（Ｊｏｕｒｎａｌ　ｏｆ　Ｐｅｓｔｉｃｉｄｅ　Ｓｃｉｅｎｃｅ）"}],"dc:publisher":[{"@language":"en","@value":"Pesticide Science Society of Japan"},{"@language":"ja","@value":"日本農薬学会"}],"prism:publicationDate":"2005","prism:volume":"30","prism:number":"3","prism:startingPage":"228","prism:endingPage":"229"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/digimeta/10877625"},{"@id":"https://dl.ndl.go.jp/pid/10877625"},{"@id":"http://www.jstage.jst.go.jp/article/jpestics/30/3/30_3_228/_pdf"},{"@id":"http://dl.ndl.go.jp/info:ndljp/pid/10877625"}],"availableAt":"2005","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=ecdysteroids","dc:title":"ecdysteroids"},{"@id":"https://cir.nii.ac.jp/all?q=ecdysone%20receptor","dc:title":"ecdysone receptor"},{"@id":"https://cir.nii.ac.jp/all?q=ultraspiracle","dc:title":"ultraspiracle"},{"@id":"https://cir.nii.ac.jp/all?q=non-steroidal%20ecdysone%20agonists","dc:title":"non-steroidal ecdysone agonists"},{"@id":"https://cir.nii.ac.jp/all?q=diacylhydrazine%20analogs","dc:title":"diacylhydrazine analogs"},{"@id":"https://cir.nii.ac.jp/all?q=selective%20toxicity","dc:title":"selective toxicity"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0025495892"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R100000039-I10877625"},{"@type":"CROSSREF","@value":"10.1584/jpestics.30.228"},{"@type":"NDL_DC","@value":"info:ndljp/pid/10877625"},{"@type":"CIA","@value":"110001788827"}]}