{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680189935360.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2330/joralbiosci.52.72"}},{"identifier":{"@type":"DOI","@value":"10.1016/s1349-0079(10)80035-0"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1349007910800350?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1349007910800350?httpAccept=text/plain"}},{"identifier":{"@type":"NAID","@value":"10027105411"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2011023673"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Potential of Periodontal Ligament Cells to Regenerate Alveolar Bone"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Regeneration of periodontal tissues, lost as a result of periodontal disease, is a key objective of periodontal treatment. Although several periodontal regeneration therapies have been devised, the origin of the undifferentiated cells that regenerate periodontal tissues remains unknown. Therefore, in the present study, to clarify the existence of osteoblast progenitor cells in the periodontal ligament, as well as to investigate the mechanism of alveolar bone regeneration without any effects from the original bone, we evaluated osteoblast differentiation induced by transplantation of GFP-transgenic rat molars into the subcutaneous tissues of wild-type rats. Ten days after transplantation, initial alveolar bone was formed apart from the cementum in the bifurcation region. After 20 days, this bone tissue had expanded to almost all of the bifurcation. GFP localization showed that the osteoblasts were derived from the transplant. Alpha-SMA- and BMP4-positive cells were observed near the root surface at 5 days after transplantation. With the progress of alveolar bone regeneration, osteoblasts expressing Runx2 and Osterix appeared in the bone-forming region. These results indicate that periodontal ligament tissue remaining on the root surface after a tooth extraction contains undifferentiated cells that have the ability to regenerate alveolar bone. The process of osteoblast differentiation in this model might be similar to that for normal alveolar bone formation. Thus, periodontal ligament cells might be useful for the regeneration of alveolar bone in tissue engineering applications."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751153923584","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70350824"},{"@type":"NRID","@value":"1000070350824"},{"@type":"KAKEN_RESEARCHERS","@value":"20264252"},{"@type":"NRID","@value":"1000020264252"},{"@type":"NRID","@value":"9000004727773"},{"@type":"NRID","@value":"9000413376312"},{"@type":"NRID","@value":"9000283603971"},{"@type":"NRID","@value":"9000257942613"},{"@type":"NRID","@value":"9000014142664"},{"@type":"NRID","@value":"9000002442551"},{"@type":"NRID","@value":"9000253177270"},{"@type":"NRID","@value":"9000415171643"},{"@type":"NRID","@value":"9000410264604"},{"@type":"NRID","@value":"9000018193873"},{"@type":"NRID","@value":"9000004731198"},{"@type":"NRID","@value":"9000319565055"},{"@type":"NRID","@value":"9000006637101"},{"@type":"NRID","@value":"9000400186626"},{"@type":"NRID","@value":"9000410264597"},{"@type":"NRID","@value":"9000406057026"},{"@type":"NRID","@value":"9000398434519"},{"@type":"NRID","@value":"9000398434507"},{"@type":"NRID","@value":"9000398625576"},{"@type":"NRID","@value":"9000397714372"},{"@type":"NRID","@value":"9000400186611"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0197474"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ykoba0726"}],"foaf:name":[{"@language":"en","@value":"Hosoya Akihiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral Histology, Matsumoto Dental 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Hidehiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Institute for Dental Science, Matsumoto Dental University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801186970496","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50227930"},{"@type":"NRID","@value":"1000050227930"},{"@type":"NRID","@value":"9000401559827"},{"@type":"NRID","@value":"9000415171644"},{"@type":"NRID","@value":"9000414754683"},{"@type":"NRID","@value":"9000351209819"},{"@type":"NRID","@value":"9000405853533"},{"@type":"NRID","@value":"9000000504584"},{"@type":"NRID","@value":"9000006382956"},{"@type":"NRID","@value":"9000257888456"},{"@type":"NRID","@value":"9000000504493"},{"@type":"NRID","@value":"9000257888005"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0009365"}],"foaf:name":[{"@language":"en","@value":"Nakamura Hiroaki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral Histology, Matsumoto Dental University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13490079"},{"@type":"EISSN","@value":"18803865"},{"@type":"NCID","@value":"AA11896386"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Oral Biosciences"},{"@language":"en","@value":"J. Oral Biosci."}],"dc:publisher":[{"@language":"en","@value":"Japanese Association for Oral Biology"},{"@language":"ja","@value":"歯科基礎医学会"}],"prism:publicationDate":"2010","prism:volume":"52","prism:number":"2","prism:startingPage":"72","prism:endingPage":"80"},"reviewed":"false","url":[{"@id":"https://api.elsevier.com/content/article/PII:S1349007910800350?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1349007910800350?httpAccept=text/plain"},{"@id":"https://search.jamas.or.jp/link/ui/2011023673"}],"availableAt":"2010","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=alveolar%20bone%20regeneration","dc:title":"alveolar bone regeneration"},{"@id":"https://cir.nii.ac.jp/all?q=GFP-transgenic%20rat","dc:title":"GFP-transgenic rat"},{"@id":"https://cir.nii.ac.jp/all?q=osteoblast%20differentiation","dc:title":"osteoblast differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=alpha-smooth%20muscle%20actin","dc:title":"alpha-smooth muscle actin"},{"@id":"https://cir.nii.ac.jp/all?q=periodontal%20ligament","dc:title":"periodontal ligament"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782028373632","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20200019"},{"@type":"JGN","@value":"JP20200019"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20200019/"}],"notation":[{"@language":"ja","@value":"骨代謝を調節するカーボンナノチューブの分子機構の解明"},{"@language":"en","@value":"Analysis of molecular mechanism of carbon nanotube regulating bone metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782059725952","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20791347"},{"@type":"JGN","@value":"JP20791347"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791347/"}],"notation":[{"@language":"ja","@value":"歯髄SP細胞を用いた象牙芽細胞分化機構の解析"},{"@language":"en","@value":"An analysis of odontoblast differentiation mechanisms by using dental pulp SP cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782137845248","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22791782"},{"@type":"JGN","@value":"JP22791782"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791782/"}],"notation":[{"@language":"ja","@value":"Thy-1陽性歯髄細胞による象牙質再生"},{"@language":"en","@value":"Dentin regeneration by Thy-1-positive dental pulp cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257027851520","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20592163"},{"@type":"JGN","@value":"JP20592163"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592163/"}],"notation":[{"@language":"ja","@value":"硬組織形成における組織幹細胞微小環境の解明"},{"@language":"en","@value":"Microenvironment of stem cells in bone 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