{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680191969280.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1269/jrr.08096"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"10279054"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/10279054"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I10279054"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/jrr/article-pdf/50/4/303/2757971/jrr-50-303.pdf"}},{"identifier":{"@type":"NAID","@value":"10025912138"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2010027279"}}],"dc:title":[{"@language":"en","@value":"Radioprotective Properties of Polyphenols from Phyllanthus amarus Linn"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Radioprotective activity of pure compounds isolated from the plant <i>Phyllanthus amarus</i> was studied using rat liver mitochondria and pBR322 plasmid DNA as an <i>in vitro</i> model system. These compounds were ellagitannins namely amariin, 1-galloyl-2,3-dehydrohexahydroxydiphenyl (DHHDP)-glucose, repandusinic acid, geraniin, corilagin, phyllanthusiin D, and flavonoids namely rutin, and quercetin 3-O-glucoside. The activity was then correlated with their hydroxyl and superoxide radical scavenging activity. Both ellagitannins and flavonoids effectively prevented lipid peroxidation and protein oxidation in mitochondria. The compounds also prevented radiation induced single strand breaks in pBR322 plasmid DNA. The radioprotective activity of ellagitannins and flavonoids could be due to their ability to scavenge different radicals more or less efficiently, relieving the oxidative stress. Protection conferred by flavonoids, rutin and quercetin 3-O-glucoside to rat liver mitochondria and plasmid pBR322 DNA from radiation induced damage was due to their strong hydroxyl radical scavenging activity. The inhibitory effect of ellagitannins on lipid peroxidation in liver mitochondria was due to their efficient superoxide radical scavenging ability. This is the first report about the radioprotective activity of pure ellagitannins from <i>Phyllanthus amarus</i>."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282680191969282","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000017037988"}],"foaf:name":[{"@language":"en","@value":"LONDHE Jayant S."}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Zoology, University of Pune"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680191969280","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000017037990"}],"foaf:name":[{"@language":"en","@value":"DEVASAGAYAM Thomas P. A."}],"jpcoar:affiliationName":[{"@language":"en","@value":"Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680191969283","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000017037996"}],"foaf:name":[{"@language":"en","@value":"GHASKADBI Saroj S."}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Zoology, University of Pune"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680191969281","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000017037993"}],"foaf:name":[{"@language":"en","@value":"FOO L. Yeap"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Industrial Research Ltd, Gracefield Research Centre"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"04493060"},{"@type":"EISSN","@value":"13499157"},{"@type":"NDL_BIB_ID","@value":"000000127791"},{"@type":"ISSN","@value":"04493060"},{"@type":"LISSN","@value":"04493060"},{"@type":"NCID","@value":"AA00705792"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Radiation Research"},{"@language":"en","@value":"JRR"}],"dc:publisher":[{"@language":"en","@value":"Journal of Radiation Research Editorial Committee"},{"@language":"ja","@value":"Journal of Radiation Research 編集委員会"}],"prism:publicationDate":"2009","prism:volume":"50","prism:number":"4","prism:startingPage":"303","prism:endingPage":"309"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/10279054"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I10279054"},{"@id":"http://academic.oup.com/jrr/article-pdf/50/4/303/2757971/jrr-50-303.pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2010027279"}],"availableAt":"2009","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Radioprotection","dc:title":"Radioprotection"},{"@id":"https://cir.nii.ac.jp/all?q=Antioxidants","dc:title":"Antioxidants"},{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3EPhyllanthus%20amarus%3C/i%3E","dc:title":"<i>Phyllanthus amarus</i>"},{"@id":"https://cir.nii.ac.jp/all?q=Ellagitannins","dc:title":"Ellagitannins"},{"@id":"https://cir.nii.ac.jp/all?q=Flavonoids","dc:title":"Flavonoids"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360292618551131520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antimicrobial potentiality of<i>Phyllanthus amarus</i>against drug resistant pathogens"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093794543360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High-Performance Thin-Layer Chromatography Densitometric Method for Simultaneous Quantitation of Phyllanthin, Hypophyllanthin, Gallic Acid, and Ellagic Acid in Phyllanthus amarus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094365521024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of an extract from Phyllanthus amarus on hepatitis B surface antigen gene expression in human hepatoma cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095833650048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anti-Inflammatory Properties of Extracts, Fractions and Lignans Isolated from<i>Phyllanthus amarus</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569451864960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phyllanthusiin D, an unusual hydrolysable tannin from Phyllanthus amarus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570141482752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protection against ionizing radiation by antioxidant nutrients and phytochemicals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571022636928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipid peroxidation and protein oxidation in patients affected by Hodgkin′s lymphoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044490327424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protein carbonylation in human diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044506387968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of experimental gastric lesion and inflammation by Phyllanthus amarus extract"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046021266944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Quantitative determination of phyllanthin and hypophyllanthin in <i>Phyllanthus</i> species by high‐performance thin layer chromatography"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520613581568","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Protein carbonyl groups as biomarkers of oxidative stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944259467136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of protein carbonyl formation and lipid peroxidation by glutathione in rat liver microsomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419774379904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Concerted inhibitory activities of Phyllanthus amarus on HIV replication in vitro and ex vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893583635328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Total phenol, antioxidant and free radical scavenging activities of some medicinal plants"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894750684416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of signal-regulated protein kinases by plant-derived hydrolysable tannins"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894954856064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Amarulone, a Novel Cyclic Hydrolysable Tannin from <i>Phyllanthus amarus</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895865595008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368463122176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"8-Oxo-2′-deoxyguanosine level in lymphocytes DNA of cancer patients undergoing radiotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370477794816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371084072576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Amariinic acid and related ellagitannins from Phyllanthus amarus"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846300337536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antihyperglycaemic and Antioxidant Effect of Rutin, a Polyphenolic Flavonoid, in Streptozotocin‐Induced Diabetic Wistar Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321321066496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795460813440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Systematics and health effects of chemically distinct tannins in medicinal plants"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268501405952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enhanced oxidative phosphorylation in rat liver mitochondria following prolonged <i>in vivo</i> treatment with imipramine"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268807901824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269921750528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In vitro antioxidant activities of methanol extracts of five Phyllanthus species from India"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205215900928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Protective Effect of an Extract of Phyllanthus amarus against Radiation-induced Damage in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681451374592","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Spectrophotometric Assay for Superoxide Dismutase Based on the Reduction of Highly Water-soluble Tetrazolium Salts by Xanthine-Xanthine Oxidase."}]},{"@id":"https://cir.nii.ac.jp/crid/1570291226715294080","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enhanced oxidative phosphorylation in rat liver mitochondria following prolonged in vivo treatment with imipramine"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700908117248","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2)"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700908119552","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of tannins on the oxidative damage of mouse ocular lens I. Using the oxidative damage model induced by the xanthine-xanthine oxidase system"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700908123008","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"High-performance thin-layer chromatography densitometric method for simultaneous quantitation of phyllanthin, hypophyllanthin, gallic acid, and ellagic acid in Phyllanthus amarus"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175884829824","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Tannis from barks of Pinus carbaea protect Escherichia coli cells against DNA damage induced by γ-rays"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175884832256","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Antimicrobial potentiality of Phyllanthus amarus against drug resistant pathogens"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176492649472","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Total phenol, antioxidant and free radical scavenging activities of some medicinal plants"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176708138752","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibition of protein carbonyl formation and lipid peroxidation by glutathione in rat liver microsomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650861538560","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650861541888","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Some novel approaches for radioprotection and the beneficial effect of natural products"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650861543552","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"8-Oxo-2'-deoxyguanosine level in lymphocytes DNA of cancer patients undergoing radiotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125838253184","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Quantitative determination of phyllanthin and hypophyllanthin in Phyllanthus species by high-performance thin layer chromatography"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126445181952","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"In vitro antioxidant activities of methanol extracts of five Phyllanthus species from India"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600814961152","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600814964864","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Amarulone, novel cyclic hydrolysable tannin from Phyllanthus amarus"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075791670912","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075791672064","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of ellagic acid, a natural polyphenol, on alcohol-induced prooxidant and antioxidant imbalance : a drug dose dependent study"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550768381056","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Systemic and health effects of chemically distinct tannins in medicinal plants"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550768384512","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibition of experimental gastric lesion and inflammation by Phyllanthus amarus extract"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550768385664","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550768387072","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572543025745097728","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evaluation of inhibitory effect of the plant Phyllanthus amarus against dermatophytic fungi Microsporum gypseum"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105975698513152","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Free radical scavenging reaction and phytochemical analysis of triphala, an ayurvedic formulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105975698514176","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Concerted inhibitory activities of Phyllanthus amarus on HIV replication in vitro and ex vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105975698518400","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The protective effect of flavonol quercetin against ultraviolet induced oxidative stress in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450675224192","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lipid peroxidation and protein oxidation in patients affected by Hodgkin's lymphoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450675225344","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Protein measurement with folin phenol reagent"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450675226496","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Phyllanthusiin D, an unusual hydrolysable tannin from Phyllanthus amarus"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450675228416","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Protein carbonylation in human diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450675229568","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of an extract from Phyllanthus amarus on hepatitis B surface antigen gene expression in human hepatoma cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387451511277440","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573668926487343872","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573950400628650752","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Protection against ionizing radiation by antioxidant nutrients and phytochemicals"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231876216669696","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"In vitro protection of DNA from Fenton reaction by plant polyphenol verbascoside"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231876396221440","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lipid peroxidation in rat uterus"}]},{"@id":"https://cir.nii.ac.jp/crid/2050870367050230912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Radioprotective activity of blackcurrant extract evaluated by in vitro micronucleus and gene mutation assays in TK6 human lymphoblastoid cells"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0033452820"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I10279054"},{"@type":"CROSSREF","@value":"10.1269/jrr.08096"},{"@type":"CIA","@value":"10025912138"},{"@type":"CROSSREF","@value":"10.1186/s41021-017-0082-z_references_DOI_PAw6pJAR4KBF8lb2lUAv73QgLnr"}]}