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The purine analogue 8-aminoadenosine (8-NH<sub>2</sub>-Ado) is known to be a transcription inhibitor that has proved very effective in multiple myeloma cell lines and primary indolent leukemia cells. In this report, to examine whether 8-NH<sub>2</sub>-Ado had the ability to enhance the radiation-induced cell killing in solid tumor cells, human lung adenocarcinoma A549 cells were irradiated in the presence and absence of 8-NH<sub>2</sub>-Ado. 8-NH<sub>2</sub>-Ado significantly increased reproductive cell death and apoptosis in A549 cells exposed to X-rays. When peptide inhibitors against caspase-3, -8, and -9 were utilized to evaluate the involvement of caspases, all inhibitors suppressed the enhancement of radiation-induced apoptosis, suggesting that not only mitochondria-mediated apoptotic signal transduction pathways but also death receptor-mediated pathways were involved in this enhancement of apoptosis. In addition, in the cells exposed to the treatment combining X-irradiation and 8-NH<sub>2</sub>-Ado, reduction of the intracellular ATP concentration was essential for survival, and down-regulation of the expression of antiapoptotic proteins such as survivin and XIAP was observed. These results indicate that 8-NH<sub>2</sub>-Ado has potential not only as an anti-tumor drug for leukemia and lymphoma but also as a radiosensitizing agent for solid tumors."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282680191972740","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000018706041"}],"foaf:name":[{"@language":"en","@value":"MEIKE Shunsuke"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido 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編集委員会"}],"prism:publicationDate":"2011","prism:volume":"52","prism:number":"4","prism:startingPage":"456","prism:endingPage":"463"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/11164106"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I11164106"},{"@id":"http://academic.oup.com/jrr/article-pdf/52/4/456/3595388/jrr-52-456.pdf"},{"@id":"http://hdl.handle.net/2115/46979"},{"@id":"https://search.jamas.or.jp/link/ui/2012169372"}],"availableAt":"2011","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Radiosensitization","dc:title":"Radiosensitization"},{"@id":"https://cir.nii.ac.jp/all?q=8-Aminoadenosine%20(8-NH%3Csub%3E2%3C/sub%3E-Ado)","dc:title":"8-Aminoadenosine (8-NH<sub>2</sub>-Ado)"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis","dc:title":"Apoptosis"}],"dcterms:subject":[{"subjectScheme":"NDC","notation":[{"@value":"460"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Radiosensitization"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"8-Aminoadenosine 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