{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680199794432.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5981/jjhnc.37.529"}},{"identifier":{"@type":"NAID","@value":"10030815595"}},{"identifier":{"@type":"NAID","@value":"130004510128"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2012092580"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Clinical review and statistical analysis of tongue squamous cell carcinoma"},{"@language":"ja","@value":"舌扁平上皮癌症例の臨床統計学的検討"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"We reviewed 86 patients with oral tongue squamous cell carcinoma who were initially treated with curative intent in the Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine between 1996 and 2007. Statistical analysis was performed to examine the prognostic value of the clinical features. Eighty patients underwent surgery and six underwent radiotherapy as the initial treatment. The five-year disease-free survival (DFS) rates determined by the Kaplan-Meier method were as follows: 75.8% in all stages, 88.7% in stage I (n = 30), 82.6% in stage II (n = 24), 77.1% in stage III (n = 14), and 39.7% in stage IV (n = 18). Univariate analysis demonstrated that stage III/IV, T 3/4, and N2 were significantly correlated with poor prognosis, whereas multivariate analysis showed that only N2 was independently correlated with poor prognosis. Neoadjuvant chemotherapy (NAC) was applied for 24 patients. Although the DFS of the responders (CR+PR) was higher than that of the non-responders (NC+PD), the difference was not significant. Among 80 patients who received surgical treatment initially, neck dissection (ND) was performed in 42 patients. Five-year DFS was significantly higher in the patients with no or single node metastasis than in the patients with multiple node metastases (93.8% vs. 32.7%). These outcomes suggest that more aggressive postoperative therapy should be recommended for patients found to have pathologically multiple positive nodes."},{"@language":"ja","@value":"1996年から2007年の間に慶應義塾大学病院耳鼻咽喉科で初回治療を行った舌扁平上皮癌86例につき臨床統計学的検討を行った。治療法の内訳は根治手術80例，根治照射6例であった。5年非担癌生存率は全体で75.8%，stage I（30例）：88.7%，stage II（24例）：82.6%，stage III（14例）：77.1%，stage IV（18例）：39.7%であった。予後因子については，単変量解析ではstage III／IV，T3/4，N2で有意差を認め，多変量解析ではN2が独立した予後不良因子であった。導入化学療法を施行した24例では，奏効群と非奏効群との間で生存率に有意差は認めなかった。根治手術群80例のうち頸部郭清を施行した42例において，リンパ節転移数2個以上群の生存率は2個未満群に比べて有意に不良であった（32.7% vs 93.8%）ことから，前者に対する術後治療の強化が必要と考えられた。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420003854341217664","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80338136"},{"@type":"NRID","@value":"1000080338136"},{"@type":"NRID","@value":"9000413739093"},{"@type":"NRID","@value":"9000347125058"},{"@type":"NRID","@value":"9000258079342"},{"@type":"NRID","@value":"9000258258200"},{"@type":"NRID","@value":"9000107393065"},{"@type":"NRID","@value":"9000391659133"},{"@type":"NRID","@value":"9000273024891"},{"@type":"NRID","@value":"9000021972012"},{"@type":"NRID","@value":"9000242087283"},{"@type":"NRID","@value":"9000258216891"},{"@type":"NRID","@value":"9000387900605"},{"@type":"NRID","@value":"9000325470050"},{"@type":"NRID","@value":"9000283512337"},{"@type":"NRID","@value":"9000257921865"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0131259"}],"foaf:name":[{"@language":"ja","@value":"坂本 耕二"},{"@language":"en","@value":"Sakamoto Koji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine"},{"@language":"ja","@value":"慶應義塾大学医学部耳鼻咽喉科学教室"},{"@language":"en","@value":"Department of Otorhinolaryngology, Saiseikai Utsunomiya Hospital"},{"@language":"ja","@value":"済生会宇都宮病院耳鼻咽喉科"}]},{"@id":"https://cir.nii.ac.jp/crid/1420003854341214720","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80255538"},{"@type":"NRID","@value":"1000080255538"},{"@type":"NRID","@value":"9000258079347"},{"@type":"NRID","@value":"9000256077031"},{"@type":"NRID","@value":"9000414837413"},{"@type":"NRID","@value":"9000398794707"},{"@type":"NRID","@value":"9000258258196"},{"@type":"NRID","@value":"9000360588665"},{"@type":"NRID","@value":"9000021972007"},{"@type":"NRID","@value":"9000258216887"},{"@type":"NRID","@value":"9000406017212"},{"@type":"NRID","@value":"9000409185265"},{"@type":"NRID","@value":"9000397686163"},{"@type":"NRID","@value":"9000387900603"},{"@type":"NRID","@value":"9000397684779"},{"@type":"NRID","@value":"9000259840067"},{"@type":"NRID","@value":"9000258226907"},{"@type":"NRID","@value":"9000258079244"},{"@type":"NRID","@value":"9000325470060"},{"@type":"NRID","@value":"9000283512336"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/yor"}],"foaf:name":[{"@language":"en","@value":"Imanishi Yorihisa"},{"@language":"ja","@value":"今西 順久"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"慶應義塾大学医学部耳鼻咽喉科学教室"},{"@language":"en","@value":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of 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俊樹"},{"@language":"en","@value":"Tomita Toshiki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine"},{"@language":"ja","@value":"慶應義塾大学医学部耳鼻咽喉科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221425207815","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000825809"},{"@type":"NRID","@value":"9000258079349"}],"foaf:name":[{"@language":"en","@value":"Ozawa Hiroyuki"},{"@language":"ja","@value":"小澤 宏之"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"慶應義塾大学医学部耳鼻咽喉科学教室"},{"@language":"en","@value":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of 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Taku"},{"@language":"ja","@value":"山下 拓"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Deparatment of Otorhinolaryngology-Head and Neck Surgery, National Defense Medical College"},{"@language":"ja","@value":"防衛医科大学校耳鼻咽喉科学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221425207813","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000389914"},{"@type":"NRID","@value":"9000258079344"}],"foaf:name":[{"@language":"en","@value":"Kanke Minoru"},{"@language":"ja","@value":"菅家 稔"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kanke Ear Nose Throat Clinic"},{"@language":"ja","@value":"菅家耳鼻咽喉科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221425207810","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256833073"}],"foaf:name":[{"@language":"en","@value":"Fujii Masato"},{"@language":"ja","@value":"藤井 正人"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"国立病院機構東京医療センター臨床研究センター"},{"@language":"en","@value":"National Institute of 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Kaoru"},{"@language":"ja","@value":"小川 郁"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine"},{"@language":"ja","@value":"慶應義塾大学医学部耳鼻咽喉科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133798876674","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40465026"},{"@type":"NRID","@value":"1000040465026"},{"@type":"NRID","@value":"9000016805976"},{"@type":"NRID","@value":"9000258079354"},{"@type":"NRID","@value":"9000021972021"}],"foaf:name":[{"@language":"en","@value":"Ootsuka Kuninori"},{"@language":"ja","@value":"大塚 邦憲"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"慶應義塾大学医学部耳鼻咽喉科学教室"},{"@language":"en","@value":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221425207814","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001637329"},{"@type":"NRID","@value":"9000258079350"}],"foaf:name":[{"@language":"en","@value":"Tagawa Takamasa"},{"@language":"ja","@value":"田川 崇正"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Noukendai Ear Nose Throat Clinic"},{"@language":"ja","@value":"能見台医院"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13495747"},{"@type":"EISSN","@value":"18818382"},{"@type":"NCID","@value":"AA11985555"}],"prism:publicationName":[{"@language":"en","@value":"Toukeibu Gan"},{"@language":"ja","@value":"頭頸部癌"},{"@language":"en","@value":"Toukeibu Gan"},{"@language":"ja","@value":"頭頸部癌"}],"dc:publisher":[{"@language":"en","@value":"Japan Society for Head and Neck 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