{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680200525440.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5981/jjhnc.38.1"}},{"identifier":{"@type":"NAID","@value":"130004510132"}},{"identifier":{"@type":"NAID","@value":"10030815669"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2012224213"}}],"dc:title":[{"@language":"en","@value":"Clinical study on multiple primary squamous cell carcinomas of the oral cavity"},{"@language":"ja","@value":"口腔多発扁平上皮癌症例の臨床的検討"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The subjects were 35 patients diagnosed with multiple squamous cell carcinomas of the oral cavity among 709 patients with primary squamous cell carcinoma of the oral cavity. The incidence of multiple squamous cell carcinomas was 4.9%. The second and third primary carcinomas frequently developed in the buccal mucosa, mandibular gingiva, tongue and maxillary gingiva. Tumor size and invasiveness of treatment tended to decrease with progression to the second and third carcinomas. The mean interval between the first and second carcinomas was 60 months, while that between the second and third carcinomas was 24.5 months. The 10-year cumulative incidence of multiple squamous cell carcinoma of the oral cavity was 13.1%, and the five-year cumulative survival rate from the onset of the second carcinoma was 81.1%. Local recurrence rate was 37.1%, which was higher than that of solitary carcinomas. The high incidence rate and recurrence rate indicate the necessity of close and long-term follow-up after the treatment of the first carcinoma. Reduced invasiveness of treatment due to early detection was thought to lead to the preservation of oral function."},{"@language":"ja","@value":"2001年4月から2009年12月までに加療した口腔扁平上皮癌の一次症例709例のうち，口腔多発癌と診断した35例を対象とした。口腔多発扁平上皮癌の発生率は4.9%であった。第2癌，第3癌は頬粘膜，下顎歯肉，舌，上顎歯肉に多く発生していた。第2癌，第3癌と進むにつれ，腫瘍の大きさおよび治療侵襲は小さくなる傾向にあった。第1癌から第2癌までの発生期間は平均60ヶ月，第2癌から第3癌までは24.5ヶ月で，第2癌の10年累積発生率は13.1%であった。第2癌発生からの5年累積生存率は81.1%であった。治療成績については，局所再発率は多発癌症例では33.8%で 単発癌症例の9.9%より高かった。10年累積発生率が高いこと，また多発癌症例では再発率が高いことより，長期にわたる慎重な経過観察が必要で，口腔多発癌の早期発見による治療侵襲の縮小が口腔機能の温存につながると考えられた。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410853646243292928","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000258079579"}],"foaf:name":[{"@language":"en","@value":"Omura Ken"},{"@language":"ja","@value":"小村 健"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Oral and Maxillofacial Surgery, Division of Oral Restitution, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University"},{"@language":"ja","@value":"東京医科歯科大学大学院医歯学総合研究科顎口腔外科学分野"}]},{"@id":"https://cir.nii.ac.jp/crid/1410853646243292929","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004728045"},{"@type":"NRID","@value":"9000258079578"}],"foaf:name":[{"@language":"en","@value":"Shimamoto Hiroaki"},{"@language":"ja","@value":"島本 裕彰"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Oral and Maxillofacial Surgery, Division of Oral Restitution, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University"},{"@language":"ja","@value":"東京医科歯科大学大学院医歯学総合研究科顎口腔外科学分野"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751161687936","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40343149"},{"@type":"NRID","@value":"1000040343149"},{"@type":"NRID","@value":"9000323840519"},{"@type":"NRID","@value":"9000398632750"},{"@type":"NRID","@value":"9000392820529"},{"@type":"NRID","@value":"9000258078941"},{"@type":"NRID","@value":"9000256078279"},{"@type":"NRID","@value":"9000326657915"},{"@type":"NRID","@value":"9000287291505"},{"@type":"NRID","@value":"9000403152634"},{"@type":"NRID","@value":"9000256077469"},{"@type":"NRID","@value":"9000005403005"},{"@type":"NRID","@value":"9000345434980"},{"@type":"NRID","@value":"9000255874500"},{"@type":"NRID","@value":"9000256078665"},{"@type":"NRID","@value":"9000403543440"},{"@type":"NRID","@value":"9000258078091"},{"@type":"NRID","@value":"9000297496495"},{"@type":"NRID","@value":"9000398277082"},{"@type":"NRID","@value":"9000298259428"},{"@type":"NRID","@value":"9000283592952"},{"@type":"NRID","@value":"9000402820709"},{"@type":"NRID","@value":"9000367423894"},{"@type":"NRID","@value":"9000254406380"},{"@type":"NRID","@value":"9000256428866"},{"@type":"NRID","@value":"9000324666388"},{"@type":"NRID","@value":"9000386101570"},{"@type":"NRID","@value":"9000398155015"},{"@type":"NRID","@value":"9000283325406"},{"@type":"NRID","@value":"9000258079580"},{"@type":"NRID","@value":"9000256078266"},{"@type":"NRID","@value":"9000402374076"},{"@type":"NRID","@value":"9000346914282"},{"@type":"NRID","@value":"9000254406524"},{"@type":"NRID","@value":"9000402587817"},{"@type":"NRID","@value":"9000283245491"},{"@type":"NRID","@value":"9000020397870"},{"@type":"NRID","@value":"9000345434975"},{"@type":"NRID","@value":"9000324641244"},{"@type":"NRID","@value":"9000258079178"}],"foaf:name":[{"@language":"en","@value":"Harada Hiroyuki"},{"@language":"ja","@value":"原田 浩之"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Oral and Maxillofacial Surgery, Division of Oral Restitution, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University"},{"@language":"ja","@value":"東京医科歯科大学大学院医歯学総合研究科顎口腔外科学分野"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13495747"},{"@type":"EISSN","@value":"18818382"},{"@type":"NCID","@value":"AA11985555"}],"prism:publicationName":[{"@language":"en","@value":"Toukeibu Gan"},{"@language":"ja","@value":"頭頸部癌"},{"@language":"en","@value":"Toukeibu Gan"},{"@language":"ja","@value":"頭頸部癌"}],"dc:publisher":[{"@language":"en","@value":"Japan Society for Head and Neck Cancer"},{"@language":"ja","@value":"日本頭頸部癌学会"}],"prism:publicationDate":"2012","prism:volume":"38","prism:number":"1","prism:startingPage":"1","prism:endingPage":"5"},"reviewed":"false","url":[{"@id":"https://search.jamas.or.jp/link/ui/2012224213"}],"availableAt":"2012","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Oral%20cancer","dc:title":"Oral cancer"},{"@id":"https://cir.nii.ac.jp/all?q=Squamous%20cell%20carcinoma","dc:title":"Squamous cell carcinoma"},{"@id":"https://cir.nii.ac.jp/all?q=Multiple%20primary%20carcinoma","dc:title":"Multiple primary carcinoma"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%8F%A3%E8%85%94%E7%99%8C","dc:title":"口腔癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%89%81%E5%B9%B3%E4%B8%8A%E7%9A%AE%E7%99%8C","dc:title":"扁平上皮癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%A4%9A%E7%99%BA%E7%99%8C","dc:title":"多発癌"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1362262944888494336","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Survival rates in 548 patients with multiple neoplasms of the upper aerodigestive tract"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204346093824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical evaluation of the oral multiple primary cancer."},{"@value":"口腔内多発癌の臨床的検討"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204346348160","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical and histological investigation of oral multiple 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