{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680201021696.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1536/ihj.51.426"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/ihj/51/6/51_6_426/_pdf"}},{"identifier":{"@type":"NAID","@value":"130000410629"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2011254673"}}],"dc:title":[{"@language":"en","@value":"Atorvastatin Prevents Left Ventricular Remodeling in Spontaneously Hypertensive Rats"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Statins improve left ventricular (LV) remodeling in spontaneously hypertensive rats (SHRs). This study was designed to investigate the effects of atorvastatin administered in the early stage on LV remodeling in SHRs, and to explore the underlying mechanisms.<br>Sixteen male 8-week-old SHRs were randomized to receive distilled water (SHR-DW) or atorvastatin (SHR-ATV) for 12 weeks. Age-matched male Wistar-Kyoto (WKY) rats gavaged with distilled water served as controls. LV remodeling was evaluated, myocardial CTGF expression levels were detected using Western blotting, and cardiomyocyte apoptosis was detected with the TUNEL method.<br>Compared with WKY and SHR-DW, atorvastatin treatment significantly decreased systolic blood pressure in SHRs; atorvastatin significantly inhibited LV remodeling, as indicated by the reduced LV weight/body weight ratio (SHR-ATV: 4.0 ± 0.4 versus SHR-DW: 4.7 ± 0.4 mg/g, <i>P</i> < 0.05), cardiomyocyte diameter (SHR-ATV: 16.2 ± 2.8 versus SHR-DW: 19.0 ± 1.0 <i>μ</i>m, <i>P</i> < 0.05), and interstitial fibrosis (SHR-ATV: 3.3 ± 2.1 versus SHR-DW: 4.5 ± 1.8%, <i>P</i> < 0.05). Compared with WKY, myocardial CTGF expression was significantly increased and cardiomyocyte apoptosis decreased in SHRs. Compared with the SHR-DW group, atorvastatin treatment significantly inhibited myocardial CTGF expression (SHR-ATV: 0.69 ± 0.21 versus SHR-DW: 1.12 ± 0.27, <i>P</i> < 0.05) and induced cardiomyocyte apoptosis in SHRs (SHR-ATV: 5.2 ± 0.6 versus SHR-DW: 1.9 ± 0.3%, <i>P</i> < 0.05).<br>The results indicate that early-stage administration of atorvastatin effectively prevented LV remodeling in SHRs, and that inhibition of myocardial CTGF expression and induction of cardiomyocyte apoptosis may be the underlying mechanisms."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282680201021698","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021879188"}],"foaf:name":[{"@language":"en","@value":"Zhao Xiao-yan"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680201021697","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021879190"}],"foaf:name":[{"@language":"en","@value":"Li Ling"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680201021701","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021879192"}],"foaf:name":[{"@language":"en","@value":"Zhang Jin-ying"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680201021700","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021879195"}],"foaf:name":[{"@language":"en","@value":"Liu Gang-qiong"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680201021696","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021879198"}],"foaf:name":[{"@language":"en","@value":"Chen Ya-li"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680201021702","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021879201"}],"foaf:name":[{"@language":"en","@value":"Yang Pei-ling"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680201021699","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021879204"}],"foaf:name":[{"@language":"en","@value":"Liu Rui-yun"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Cardiology, the First Affiliated Hospital, Zhengzhou University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13492365"},{"@type":"LISSN","@value":"13492365"},{"@type":"EISSN","@value":"13493299"}],"prism:publicationName":[{"@language":"en","@value":"International Heart Journal"},{"@language":"en","@value":"Int. Heart J."}],"dc:publisher":[{"@language":"en","@value":"International Heart Journal Association"},{"@language":"ja","@value":"一般社団法人 インターナショナル・ハート・ジャーナル刊行会"}],"prism:publicationDate":"2010","prism:volume":"51","prism:number":"6","prism:startingPage":"426","prism:endingPage":"431"},"reviewed":"false","url":[{"@id":"http://www.jstage.jst.go.jp/article/ihj/51/6/51_6_426/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2011254673"}],"availableAt":"2010","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Atorvastatin","dc:title":"Atorvastatin"},{"@id":"https://cir.nii.ac.jp/all?q=Spontaneously%20hypertensive%20rats","dc:title":"Spontaneously hypertensive rats"},{"@id":"https://cir.nii.ac.jp/all?q=Left%20ventricular%20remodeling","dc:title":"Left ventricular remodeling"},{"@id":"https://cir.nii.ac.jp/all?q=Connective%20tissue%20growth%20factor","dc:title":"Connective tissue growth factor"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144336276992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094547085568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>IN VITRO</i> INHIBITORY EFFECTS OF ATORVASTATIN ON CARDIAC FIBROBLASTS: IMPLICATIONS FOR VENTRICULAR REMODELLING"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095875038336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiotensin Type 1 Receptor Blockade Prevents Cardiac Remodeling in Mice with Pregnancy-Associated Hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096203700480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Relationship between cardiomyocyte cell death and cardiac function during hypertensive cardiac remodelling in Dahl rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569953465600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Apoptosis as an instrument in cardiovascular development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571044711168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"miR-133 and miR-30 Regulate Connective Tissue Growth Factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045567742080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CCN3 (NOV) Is a Negative Regulator of CCN2 (CTGF) and a Novel Endogenous Inhibitor of the Fibrotic Pathway in an in Vitro Model of Renal Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518795293568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reduction in Blood Pressure With Statins<subtitle>Results From the UCSD Statin Study, a Randomized Trial</subtitle>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519087219712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Left ventricular hypertrophy, apoptosis, and progression to heart failure in severe aortic stenosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519360617600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiovascular remodeling, apoptosis, and drugs"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519380450944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular mechanisms of cardiac hypertrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520027017600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of Connective Tissue Growth Factor by Angiotensin II"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521009326720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"rAAV-mediated angiogenin gene transfer induces angiogenesis and modifies left ventricular remodeling in rats with myocardial infarction"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994170337280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"HMG-CoA Reductase Inhibitors Decrease Angiotensin II–Induced Vascular Fibrosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943622430464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Apoptosis in Target Organs of Hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369352961408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Beneficial Effect of Atorvastatin on Left Ventricular Remodeling in Spontaneously Hypertensive Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369923477760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of Statins on Blood Pressure: A Review of the Experimental and Clinical Evidence."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370632173440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevention of cardiac remodeling after myocardial infarction in transgenic rats deficient in brain angiotensinogen"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371277472512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Apoptotic cardiomyocyte death in fatal myocarditis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845183845120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Atorvastatin reverses cardiac remodeling possibly through regulation of Protein Kinase D/Myocyte Enhancer Factor 2D activation in spontaneously hypertensive rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846014825216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fluvastatin Induces Apoptosis in Rat Neonatal Cardiac Myocytes: A Possible Mechanism of Statin-Attenuated Cardiac Hypertrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319201126912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiotensin II-Stimulated Collagen Synthesis in Aortic Adventitial Fibroblasts Is Mediated by Connective Tissue Growth Factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793625028480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794530642688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synergistic effect of amlodipine and atorvastatin on blood pressure, left ventricular remodeling, and C-reactive protein in hypertensive patients with primary hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270422234752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"RNA interfering connective tissue growth factor prevents rat hepatic stellate cell activation and extracellular matrix production"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0036052491"},{"@type":"CROSSREF","@value":"10.1536/ihj.51.426"},{"@type":"CIA","@value":"130000410629"}]}