Are there thresholds for carcinogenicity on genotoxic carcinogens?

DOI

Bibliographic Information

Other Title
  • 遺伝毒性発がん物質の閾値：頂上征服への一途上

Description

Until recently it has been generally considered that genotoxic carcinogens have no threshold in exerting their potential for cancer induction. However, the non-threshold theory can be challenged with regard to assessment of cancer risk to humans. In the present study we show that food-related genotoxic hepatocarcinogens, heterocyclic amines and N-nitroso compounds at low doses do not induce preneoplastic lesions and cancer-related markers in rat medium-term carcinogenicity bioassay. The results imply existence of a threshold, at least practical one, for carcinogenicity of genotoxic carcinogens.

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Details 詳細情報について

  • CRID
    1390282680232343168
  • NII Article ID
    130004469070
  • DOI
    10.11171/chemobio.1.10
  • ISSN
    13499041
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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