{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680260975232.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5106/jjshns.25.155"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jjshns/25/2/25_155/_pdf"}},{"identifier":{"@type":"NAID","@value":"130005113095"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2016056102"}}],"dc:title":[{"@language":"ja","@value":"頭頸部癌に対する集学的治療の進歩"},{"@language":"en","@value":"The progress of multimodality treatment for head and neck cancer with special reference to chemoradiotherapy"}],"dcterms:alternative":[{"@language":"ja","@value":"—化学放射線療法を中心に—"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Regarding chemoradiotherapy for head and neck cancers, evidence for the standard treatment is reported. When chemotherapy is used together, the use of single CDDP together is the standard. The JCOG head and neck cancer group was set up in recent years, and clinical trials to develop a standard regimen have begun. JCOG1008 is studying post-operative chemoradiotherapy for high-risk patients. JCOG1212 is studying super-selective intra-arterial chemoradiotherapy for maxillary sinus cancer. On the other hand, sometimes chemoradiotherapy is an unsuitable treatment due to its toxicity. It is also reported that patients cannot achieve long-term survival even if chemoradiotherapy is successful due to late toxicity. Long-term improvement of chemoradiotherapy results is expected by devising drug therapies such as using cetuximab in the future."},{"@language":"ja","@value":"頭頸部癌に対する化学放射線療法は標準治療としてのエビデンスが報告されている。併用する化学療法はCDDP単独併用が標準となっている。近年JCOG頭頸部がんグループが組織され，標準的レジメンの開発を目的に臨床試験が開始されている。そこでは術後化学放射線療法のJCOG1008と上顎洞癌に対する超選択的動注化学放射線療法であるJCOG1212が施行されている。一方，化学放射線療法の問題点としては化学放射線療法の強い毒性のために不十分な治療となる場合や，晩期毒性によって根治治療に成功しても長期生存に結びつかないことが報告されている。今後は，分子標的薬であるセツキシマブの併用など薬物療法の工夫によりさらに化学放射線療法の長期成績向上が期待される。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679987956480","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259322807"}],"foaf:name":[{"@language":"ja","@value":"藤井 正人"},{"@language":"en","@value":"Fujii Masato"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otolaryngology, National Hospital Organization Tokyo Medical Center"},{"@language":"ja","@value":"国立病院機構東京医療センター臨床研究センター聴覚平衡覚研究部"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1349581X"},{"@type":"EISSN","@value":"1884474X"}],"prism:publicationName":[{"@language":"en","@value":"JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY"},{"@language":"ja","@value":"頭頸部外科"},{"@language":"en","@value":"J Jpn Soc Head Neck Surg"},{"@language":"en","@value":"Toukeibu geka"},{"@language":"ja","@value":"頭頸部外科"},{"@language":"en","@value":"J J pn Soc Head Neck Surg"}],"dc:publisher":[{"@language":"en","@value":"JAPAN SOCIETY FOR HEAD AND NECK SURGERY"},{"@language":"ja","@value":"特定非営利活動法人 日本頭頸部外科学会"}],"prism:publicationDate":"2015","prism:volume":"25","prism:number":"2","prism:startingPage":"155","prism:endingPage":"159"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.jstage.jst.go.jp/article/jjshns/25/2/25_155/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2016056102"}],"availableAt":"2015","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E5%8C%96%E5%AD%A6%E6%94%BE%E5%B0%84%E7%B7%9A%E7%99%82%E6%B3%95","dc:title":"化学放射線療法"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%A1%93%E5%BE%8C%E5%8C%96%E5%AD%A6%E6%94%BE%E5%B0%84%E7%B7%9A%E7%99%82%E6%B3%95","dc:title":"術後化学放射線療法"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%BB%E3%83%84%E3%82%AD%E3%82%B7%E3%83%9E%E3%83%96","dc:title":"セツキシマブ"},{"@id":"https://cir.nii.ac.jp/all?q=chemoradiotherapy","dc:title":"chemoradiotherapy"},{"@id":"https://cir.nii.ac.jp/all?q=post-operative%20chemoradiotherapy","dc:title":"post-operative chemoradiotherapy"},{"@id":"https://cir.nii.ac.jp/all?q=cetuximab","dc:title":"cetuximab"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144680790400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Randomized Trial of Radiation Therapy Versus Concomitant Chemotherapy and Radiation Therapy for Advanced-Stage Oropharynx Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145676177152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phase II Trial of Concurrent Chemoradiotherapy with S-1 Plus Cisplatin in Patients with Unresectable Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Japan Clinical Oncology Group Study (JCOG0706)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692557762944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Concomitant Weekly Cisplatin and Radiotherapy for Head and Neck 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