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- 大石 徹
- 大阪大学大学院理学研究科 大阪大学大学院理学研究科化学専攻・助教授
書誌事項
- タイトル別名
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- Total Synthesis of Ciguatoxin CTX3C
- チョウビリョウ カイサン シンケイ ドク シガトキシン CTX3C ノ ゼンゴウセイ
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説明
Ciguatoxins are the causative neurotoxins of ciguatera seafood poisoning, and more than 20, 000 people suffer annually from ciguatera disease in subtropical and tropical regions. The extremely low content of ciguatoxins in fish has hampered the isolation and detailed biological studies. The complicated and huge, 3 nm long, molecular structure of ciguatoxins has impeded synthetic chemists from completing their total syntheses, which are formidable synthetic challenge in modern organic synthesis. Our highly convergent strategic approach featuring the chemoselective ring closing metathesis (RCM) reaction as a key tactics, (i) alkylative coupling and RCM, (ii) intramolecular carbonyl olefination and reductive etherification, (iii) chemo-and regioselective radical cyclization and RCM, has enabled the first total synthesis of ciguatoxin CTX 3 C, which will provide the practical supply for further studies.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 61 (6), 562-571, 2003
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680288463744
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- NII論文ID
- 10011906213
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 6612891
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可