The effect of palliative radiation therapy on three dogs with prostatic carcinoma

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  • Fujita Michio
    Departments of Veterinary Radiology, Nippon Veterinary and Life Science University
  • Shimakura Hidekatsu
    Departments of Veterinary Radiology, Nippon Veterinary and Life Science University
  • Hasegawa Daisuke
    Departments of Veterinary Radiology, Nippon Veterinary and Life Science University
  • Taniguchi Akiko
    Yamazaki College of Animal Health Technology
  • Kawakami Eiichi
    Veterinary Reproduction, Nippon Veterinary and Life Science University
  • Orima Hiromitsu
    Departments of Veterinary Radiology, Nippon Veterinary and Life Science University

Bibliographic Information

Other Title
  • 前立腺癌の犬3例に対する緩和的放射線治療の効果
Published
2010
DOI
  • 10.12951/jvcs.1.20
Publisher
Japan Veterinary Cancer Society

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Description

High dose low-fractionated radiation therapy (a total of 32 or 36 Gy in four or six fractions of once a week) was performed for the purpose of palliation on three dogs with prostatic carcinoma, which was characterized by a high incidence of local invasion as well as metastasis. Hematuria seen in Case 1 improved after radiation therapy, while Response Evaluation Criteria in Solid Tumors (RECIST) criteria of PR in one and SD in two of the dogs were observed when the prostate size was measured using MRI. Moreover, cancerous invasion inside as well as around the prostatic gland showed improvement after therapy. The period of remission was 12, 7 and 3 months in Case 1, 2 and 3, respectively during follow-up. The above results suggest the potential efficacy of high dose-low fractionated radiation therapy for palliative treatment of canine prostatic carcinoma.

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