{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680306283264.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2974/kmj1951.15.309"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"8158929"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/8158929"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I8158929"}},{"identifier":{"@type":"NAID","@value":"130003689383"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1966031759"}}],"dc:title":[{"@language":"en","@value":"EXPERIMENTAL STUDIES ON THE ACTIVE IMMUNIZATION OF GUINÉA PIGS BY HEATED HABU SNAKE VENOM"},{"@value":"加熱ハブ毒による能動免疫に関する実験的研究"},{"@language":"ja-Kana","@value":"カネツ ハブ ドク ニ ヨル ノウドウ メンエキ ニ カンスル ジッケンテキ ケンキュウ"}],"description":[{"type":"abstract","notation":[{"@language":"en","@value":"Immunization with heated Habu Snake venom was attempted on guinea pigs.<BR>1. Freund's incomplete adjuvant was added to equivalent volumes of supernatants of heated Habu Snake venom (50mg/1.0ml in 0.85% saline), and 1. 0ml of the mixture was subcutaneously injected into the back of guinea pigs. One week after, 0. 1ml of the heated venom (500γ/0.1ml) was injected one time as additional immunization (booster) <BR>2. When, at two to twelve week after the final immunization, the animals were challenged by injecting 500γ or less of the crude venom into the femoral muscles, the grade and extension of the local damage in them were 1/3 to 1/4 as small as those in the nonimmunized animals.<BR>3. When 0. 1ml of the sera obtained from the immunized animals was mixed <I>in vitro</I> with various amounts of the crude and the heated venoms and the mixture were injected intramuscularly into the legs of mice, they depressed the local pathological changes which were visible after injection of 64γ to 34γ of the crude venom or heated venom obtained from 500γ to 250γ of the crude venom."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326228003712","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10222019"},{"@type":"NRID","@value":"1000010222019"},{"@type":"ORCID","@value":"0000-0002-6805-8351"},{"@type":"NRID","@value":"9000003910116"},{"@type":"NRID","@value":"9000272963616"},{"@type":"NRID","@value":"9000004656485"},{"@type":"NRID","@value":"9000253672403"},{"@type":"NRID","@value":"9000008724182"},{"@type":"NRID","@value":"9000238323605"},{"@type":"NRID","@value":"9000256032123"},{"@type":"NRID","@value":"9000256580555"},{"@type":"NRID","@value":"9000256252174"},{"@type":"NRID","@value":"9000002933840"},{"@type":"NRID","@value":"9000000962441"},{"@type":"NRID","@value":"9000415082329"},{"@type":"NRID","@value":"9000005339447"},{"@type":"NRID","@value":"9000002828932"},{"@type":"NRID","@value":"9000413777537"},{"@type":"NRID","@value":"9000256849648"},{"@type":"NRID","@value":"9000347046152"},{"@type":"NRID","@value":"9000002019434"},{"@type":"NRID","@value":"9000270141396"},{"@type":"NRID","@value":"9000253331155"},{"@type":"NRID","@value":"9000018903566"},{"@type":"NRID","@value":"9000404479125"},{"@type":"NRID","@value":"9000022096134"},{"@type":"NRID","@value":"9000255825568"},{"@type":"NRID","@value":"9000009162450"},{"@type":"NRID","@value":"9000006152333"},{"@type":"NRID","@value":"9000020781613"},{"@type":"NRID","@value":"9000009345734"},{"@type":"NRID","@value":"9000275823329"},{"@type":"NRID","@value":"9000001829354"},{"@type":"NRID","@value":"9000006846690"},{"@type":"NRID","@value":"9000350556463"},{"@type":"NRID","@value":"9000009349309"},{"@type":"NRID","@value":"9000364232746"},{"@type":"NRID","@value":"9000004724037"},{"@type":"NRID","@value":"9000009884859"},{"@type":"NRID","@value":"9000007381453"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0185568"}],"foaf:name":[{"@language":"en","@value":"Sato Makoto"},{"@language":"ja","@value":"佐藤 信"}],"jpcoar:affiliationName":[{"@language":"en","@value":"First Department of Pathology, School of Medicine, Gunma University"},{"@language":"ja","@value":"群馬大学医学部第1病理学教室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00231908"},{"@type":"EISSN","@value":"18836135"},{"@type":"NDL_BIB_ID","@value":"000000004846"},{"@type":"ISSN","@value":"13432826"},{"@type":"LISSN","@value":"13432826"},{"@type":"NCID","@value":"AN10585677"}],"prism:publicationName":[{"@language":"en","@value":"The KITAKANTO Medical Journal"},{"@language":"ja","@value":"北関東医学"},{"@language":"en","@value":"kmj"},{"@language":"ja","@value":"ｋｍｊ"}],"dc:publisher":[{"@language":"en","@value":"The Kitakanto Medical Society"},{"@language":"ja","@value":"北関東医学会"}],"prism:publicationDate":"1965","prism:volume":"15","prism:number":"4","prism:startingPage":"309","prism:endingPage":"316"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/8158929"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I8158929"},{"@id":"https://search.jamas.or.jp/link/ui/1966031759"}],"availableAt":"1965","dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0035747126"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I8158929"},{"@type":"CROSSREF","@value":"10.2974/kmj1951.15.309"},{"@type":"CIA","@value":"130003689383"},{"@type":"OPENAIRE","@value":"doi_dedup___::a1d2fc17d514f32ef46de248881dbb6a"}]}