Structure Analysis of Marine Natural Products and Their Binding Position Analysis on the Target Molecules by Using Mass Spectrometry

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  • Kita Masaki
    Graduate School of Bioagricultural Sciences, Nagoya University

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  • 質量分析を用いた海洋天然物の構造解析および標的分子における結合位置解析
  • シツリョウ ブンセキ オ モチイタ カイヨウ テンネンブツ ノ コウゾウ カイセキ オヨビ ヒョウテキ ブンシ ニ オケル ケツゴウ イチ カイセキ

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<p>In this review, two marine natural products, durinskiol A, a huge polyol compound from the cultured symbiotic dinoflagellate Durinskia sp., and aplyronine A, an antitumor macrolide from the sea hare Aplysia sp., are highlighted. We have developed a fluorescent labeling method for MS/MS analysis to establish the planar structure of durinskiol A. We also discovered 6-amidopyrene as a highly detectable tag for label-assisted laser desorption/ionization mass spectrometry (LA-LDI MS) without matrixes. Two amidopyrene derivatives of aplyronine A were synthesized, and their LA-LDI MS and MS/MS analyses to determine the binding position of the target protein actin are described.</p>

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