アミロイド線維形成のインキュベーション時間依存性

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タイトル別名
  • Incubation time dependence of amyloid fibril formation
  • 奨励賞受賞論文 アミロイド線維形成のインキュベーション時間依存性--伸長流動複屈折の測定
  • ショウレイショウ ジュショウ ロンブン アミロイド センイ ケイセイ ノ インキュベーション ジカン イソンセイ シンチョウ リュウドウフククッセツ ノ ソクテイ
  • -mesurements of elongational birefringence-
  • -伸長流動複屈折の測定-

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説明

Amyloid fibrils are considered to cause various serious amyloidoses including Alzheimer and prion diseases. Though their structures and mechanism of assembly have been recently studied extensively, denaturing condition of amyloid precursor protein and the process of amyloid fibril formation remain unclear. According to predicted molecular structure of amyloid fibrils, strong birefringence signals were expected to be observed when fibrils were aligned parallel. In order to investigate an incubation time dependence of amyloid fibril formation, flow induced birefringence was observed. Up to 3 hours of incubation, plateau birefringence value, Δn0, increased with incubation time, while it leveled off for more than 3 hours. With the increase in Δn0, rotational diffusion coefficient seemed to decrease synchronously. On the basis of these results, a model for amyloid fibrilogenesis was proposed.

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