{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680471529344.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11553/antibiotics1968b.59.373"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BD28Xht1aisLjP"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"8554129"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/8554129"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I8554129"}},{"identifier":{"@type":"NAID","@value":"130004396047"}},{"identifier":{"@type":"NAID","@value":"10018297698"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2007050806"}}],"dc:title":[{"@language":"en","@value":"RELATIONSHIP BETWEEN PROTEIN BINDING AND ANTIMICROBIAL ACTIVITIES OF ANTIBIOTICS AGAINST<I>Streptococcus pneumoniae</I> AND <I>Haemophilus influenzae</I>"},{"@language":"ja","@value":"<I>Streptococcus pneumoniae</I>及び<I>Haemophilus influenzae</I>に対する抗菌薬の抗菌活性と蛋白結合の検討"},{"@value":"Streptococcus pneumoniae及びHaemophilus influenzaeに対する抗菌薬の抗菌活性と蛋白結合の検討"},{"@language":"ja-Kana","@value":"Streptococcus pneumoniae オヨビ Haemophilus influenzae ニ タイスル コウキンヤク ノ コウキン カッセイ ト タンパク ケツゴウ ノ ケントウ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Fifty isolates of <I>Streptococcus pneumoniae</I> and 42 isolates of <I>Haemophilus influenzae</I> were isolated from the blood of children admitted to pediatric wards of hospitals in subprefucture between January 1998 and December 2005. The susceptibilities were measured by a microbroth dilution method using a standard broth and a broth containing 4.5% albumin. Against <I>S. pneumoniae</I>, penicillin G, ampicillin, cefotaxime, ceftriaxone, panipenem, meropenem, vancomycin, cefditoren, cefcapene, cefteram, faropenem and tebipenem were used and against <I>H. influenzae</I>, ampicillin, piperacillin, cefotaxime, ceftriaxone, panipenem, meropenem, clavulanic acid/ amoxicillin, cefditoren, cefcapene, cefteram, faropenem and tebipenem were used. Against <I>S. pneumoniae</I>, tebipenem was the highest antimicrobial activity in oral antibiotics (MIC<SUB>90</SUB>;<0.06μg/ml) and panipenem showed the highest activity for intravenous antibiotics (MIC<SUB>90</SUB>;<0.12μg/ml). Against <I>H. influenzae</I>, cefditoren was the highest activity for oral antibiotics (MIC<SUB>90</SUB>;<0.06μg/ml) and meropenem showed the highest activity for intravenous antibiotics (MIC<SUB>90</SUB>;<0.06μg/ml). The MIC90S measured by albumin containing broth were higher than those measured by standard broth. Protein binding rates of ceftriaxone, cefditoren, and faropenem were greater than 90%, and the MIC<SUB>90</SUB> of these antibiotics measured by albumin addition methods were over 4-fold higher than those measured by standard methods."},{"@language":"ja","@value":"1998年から2005年までに小児の血液から分離された<I>Streptococcus pneumoniae</I> 50株と<I>Haemophilus influenzae</I> 42株について薬剤感受性試験を行った。感受性試験はNCCLSに準じた培地と4.5%ヒト血清albumin添加した培地で微量液体希釈法で測定を行った。測定した薬剤は, <I>S.pneumoniae</I>ではpenicillin G (PCG), ampicillin (ABPC), cefteram (CFTM), cefditoren (CDTR), cefcapene (CFPN), cefotaxime (CTX), ceftriaxone (CTRX), faropenem (FRPM), panipenem (PAPM), meropenem (MEPM), vancomycin (VCM), tebipenem, <I>H.influenzae</I>ではABPC, clavulanic acid/amoxicillin (CVA/AMPC), piperacillin (PIPC), CFTM, CDTR, CFPN, CTX, CTRX, FRPM, PAPM, MEPM, tebipenemである。<I>S.pneumoniae</I>に対して最も抗菌力が優れていた経口剤はtebipenem (MIC<SUB>90</SUB>; ≤0.06μg/ml), 注射剤はPAPM (MIC<SUB>90</SUB>;≤0.12μg/ml) であった。<I>H. influenzae</I>では経口剤がCDTR (MIC<SUB>90</SUB>;≤0.06μg/ml), 注射剤がMEPM (MIC<SUB>90</SUB>;≤0.06μg/ml) であった。Albuminを添加した培地では, 蛋白結合率が高い薬剤ほどMIC90が上昇していた。そして, 蛋白結合率が90%をこえるCTRX, CDTR, FRPMではMIC<SUB>90</SUB>が4倍以上に上昇を認めた。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410572171886486912","@type":"Researcher","foaf:name":[{"@language":"en","@value":"SAKATA HIROSHI"},{"@language":"ja","@value":"坂田 宏"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pediatrics, Asahikawa Kosei Hospital"},{"@language":"ja","@value":"旭川厚生病院小児科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03682781"},{"@type":"LISSN","@value":"03682781"},{"@type":"EISSN","@value":"21865477"},{"@type":"NDL_BIB_ID","@value":"000000000264"},{"@type":"ISSN","@value":"03682781"},{"@type":"NCID","@value":"AN00002626"}],"prism:publicationName":[{"@language":"en","@value":"The Japanese Journal of Antibiotics"},{"@language":"ja","@value":"The Japanese Journal of Antibiotics"},{"@language":"en","@value":"JJA"},{"@language":"en","@value":"Jpn J Antibiot."},{"@language":"en","@value":"Jpn. J. Antibiotics"},{"@language":"ja","@value":"Jpn. J. Antibiotics"},{"@language":"ja","@value":"JJA"}],"dc:publisher":[{"@language":"en","@value":"Japan Antibiotics Research Association"},{"@language":"ja","@value":"公益財団法人 日本感染症医薬品協会"}],"prism:publicationDate":"2006","prism:volume":"59","prism:number":"5","prism:startingPage":"373","prism:endingPage":"381"},"url":[{"@id":"http://id.ndl.go.jp/bib/8554129"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I8554129"},{"@id":"https://search.jamas.or.jp/link/ui/2007050806"}],"availableAt":"2006","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360574095655105792","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Antibiotic susceptibility according to genotype of penicillin-binding protein and macrolide resistance genes, and serotype of Streptococcus pneumoniae isolates from community-acquired pneumonia in children"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419082728960","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"High prevalence of type b  -lactamase-non-producing ampicillin-resistant Haemophilus influenzae in meningitis: the situation in Japan where Hib vaccine has not been introduced"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370041689344","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Effect of protein binding on antibiotic activity <i>in vivo</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680473223296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"<I>IN VITRO</I> AND <I>IN VIVO</I> ACTIVITIES OF CEFPODOXIMEPROXETIL AGAINST PENICILLIN-RESISTANT<I>Streptococcus pneumoniae</I>"},{"@language":"ja","@value":"ペニシリン耐性肺炎球菌に対するcefpodoxime proxetilの<I>in vitro</I>および<I>in vivo</I>抗菌力"}]},{"@id":"https://cir.nii.ac.jp/crid/1520009408628092032","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"小児呼吸器感染症診療ガイドラインで推奨される常用量経口抗菌薬療法の妥当性"},{"@language":"ja-Kana","@value":"ショウニ コキュウキ カンセンショウ シンリョウ ガイドライン デ スイショウ サレル ジョウヨウリョウ ケイコウ コウキンヤク リョウホウ ノ ダトウセイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176700371456","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Antimicrobial activity of ceftriaxone versus cefotaxime : negative effect of serum albumin binding of ceftriaxone"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650352130560","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Performance standards for antimicrobial susceptibility testing-twelfth informational supplement"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075282238976","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Protein binding and its significance in antibacterial therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980076583115776","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Relevance of serum protein binding of cefoxitin and cefazolin to their activities against Klebsiella pneumoniae pneumonia in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025235660544","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Treatment of lower respiratory tract infections with ceftriaxone and cefotaxime. A comparative study"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026527244672","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Randomised comparison of chloramphenicol, ampicillin, cefotaxime, and ceftriaxone for childhood bacterial meningitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500504456576","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"In vitro activity of tebipenem, a new oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus pneumoniae"},{"@value":"In Vitro Activity of Tebipenem, a New Oral Carbapenem Antibiotic, against Penicillin-Nonsusceptible             <i>Streptococcus pneumoniae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387451524756224","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparative in vitro killing activities of meropenem, imipenem, ceftriaxone, and ceftriaxone plus vancomycin at clinically achievable cerebrospinal fluid concentrations against penicillin-resistant Streptococcus pneumoniae isolates from children with meningitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668925142501632","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of protein binding on serum bactericidal activities of ceftazidime and cefoperazone in healthy volunteers"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950401170030464","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparison of ceftriaxone with cefotaxime in serious chest infections"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:1001879422"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I8554129"},{"@type":"CIA","@value":"130004396047"},{"@type":"CIA","@value":"10018297698"}]}