{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680479214592.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1538/expanim1978.35.2_175"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"3086414"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/3086414"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I3086414"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/expanim1978/35/2/35_2_175/_pdf"}},{"identifier":{"@type":"NAID","@value":"130005000528"}},{"identifier":{"@type":"NAID","@value":"130006134613"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1987175941"}}],"dc:title":[{"@language":"ja","@value":"シリアンハムスターに出現した振戦を伴う黒毛色ハムスター (black tremor) の特性およびその遺伝子分析"},{"@language":"en","@value":"Genetical Analysis and Characterization of a New Mutant, Black Tremor Appearing in the Syrian Hamster"},{"@language":"ja-Kana","@value":"シリアンハムスター ニ シュツゲンシタ シンセン オ トモナウ コクケイロ ハ"}],"description":[{"type":"abstract","notation":[{"@language":"en","@value":"A black coat-color mutant with tremor was discovered in babies of 61 generations of an inbred strain APG of Syrian hamster which had been maintained in the Nippon Institute for Biological Science, Laboratory Animal Research Station. The genetical analysis by matings between four inbred strains which had different genes in the E and B loci and four mutant strains which were introduced the mutant gene into the four inbred strains and characterization were carried out on the mutant. The results obtained are summarized as follows: 1) The mutation occurred in a different locus with E and B loci. 2) The mutant was controlled by an autosomal recessive gene designated as“<I>bt</I>”, and it was thought that both tremor and black coat-color were the pleiotropic effect of <I>bt</I> gene. 3) At least one <I>E</I> gene in the E locus was necessary for the appearance of black coat color. Therefore, the coat-color remained cream in <I>ee</I> (cream) hamsters showing only trembling. 4) The degree of blackness of the coat-color of <I>EE</I> hamsters differed from <I>Ee</I> ones. The former was darker than the latter. 5) The mutant may be a useful animal model for studying abnormal myelogenesis and biosynthesis of melanin."},{"@language":"ja","@value":"日本生物科学研究所付属実験動物研究所で維持している近交系APG系の全兄妹交配61代において, 振戦を伴う黒毛色のハムスタ (black tremorと命名) が出現した。このミュータント形質の遺伝子分析のために毛色を支配しているE, B両座位が異なる4近交系およびそれらと同じ毛色を有する個体へblack tremor遺伝子を導入して育成した4ミュタント系を用い, 種々の交配を行うとともにblack tremorの特性を検索した。得られた結果は次のように要約される。1.black tremorはEおよびB両座位における突然変異ではない。2.black tremorは常染色体性の単一劣性遺伝子“bt”により支配され, 毛色の黒色化と振戦両形質は“bt”遺伝子の多面発現と考えられる。3.毛色の黒色化発現にはE座位に少なくとも1つのE遺伝子が必要である。このためee (クリーム色) 個体では毛色の黒色化は発現せずクリーム色のままで, 振戦のみが発現する。4毛色の黒色化の程度はEE個体とEe個体とで異なり, 前者は後者より黒色化が激しい。5.振戦の原因と思われる中枢神経系のミエリン形成遅延症およびメラニンの生合成過程の研究用モデル動物としての可能性が考察された。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030285133367191808","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40072467"},{"@type":"NRID","@value":"1000040072467"},{"@type":"NRID","@value":"9000414358513"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0157144"}],"foaf:name":[{"@language":"ja","@value":"水谷 誠"},{"@language":"en","@value":"MIZUTANI Makoto"}],"jpcoar:affiliationName":[{"@language":"en","@value":"<I>Nippon Institute for Biological Science, Laboratory Animal Research Station</I>"},{"@language":"ja","@value":"(財) 日本生物科学研究所付属実験動物研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680479214592","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283705814"},{"@type":"NRID","@value":"9000367853545"}],"foaf:name":[{"@language":"ja","@value":"勝家 康富"},{"@language":"en","@value":"KATSUIE Yasutomi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"<I>Nippon Institute for Biological Science, Laboratory Animal Research Station</I>"},{"@language":"ja","@value":"(財) 日本生物科学研究所付属実験動物研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680479214595","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283705815"},{"@type":"NRID","@value":"9000367853546"}],"foaf:name":[{"@language":"ja","@value":"梅沢 英彦"},{"@language":"en","@value":"UMEZAWA Hidehiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"<I>Nippon Institute for Biological Science, Laboratory Animal Research Station</I>"},{"@language":"ja","@value":"(財) 日本生物科学研究所付属実験動物研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680479214594","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283705816"},{"@type":"NRID","@value":"9000367853547"}],"foaf:name":[{"@language":"ja","@value":"倉益 茂実"},{"@language":"en","@value":"KURAMASU Shigemi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"<I>Nippon Institute for Biological Science, Laboratory Animal Research Station</I>"},{"@language":"ja","@value":"(財) 日本生物科学研究所付属実験動物研究所"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00075124"},{"@type":"EISSN","@value":"18817122"},{"@type":"NDL_BIB_ID","@value":"000000010095"},{"@type":"ISSN","@value":"00075124"},{"@type":"LISSN","@value":"00075124"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00075124"},{"@type":"NCID","@value":"AN00104954"}],"prism:publicationName":[{"@language":"en","@value":"Experimental Animals"},{"@language":"ja","@value":"Experimental Animals"},{"@language":"en","@value":"Experimental Animals"},{"@language":"ja","@value":"Experimental Animals"}],"dc:publisher":[{"@language":"en","@value":"Japanese Association for Laboratory Animal Science"},{"@language":"ja","@value":"公益社団法人 日本実験動物学会"}],"prism:publicationDate":"1986","prism:volume":"35","prism:number":"2","prism:startingPage":"175","prism:endingPage":"179"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/3086414"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I3086414"},{"@id":"https://www.jstage.jst.go.jp/article/expanim1978/35/2/35_2_175/_pdf"},{"@id":"https://jlc.jst.go.jp/DN/JALC/10022449350?from=CiNii"},{"@id":"https://search.jamas.or.jp/link/ui/1987175941"}],"availableAt":"1986","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390282679391119488","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Impaired Myelinogenesis and Early Maturation of Oligodendrocytes in Black Tremor Hamster with Central Nervous System Myelin Deficiency"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679815701504","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"ABR of new mutant hamster having myelinating disorder."},{"@value":"ミエリン形成不全を呈する新しいミュータントハムスターのＡＢＲ"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2002165413"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I3086414"},{"@type":"CROSSREF","@value":"10.1538/expanim1978.35.2_175"},{"@type":"CIA","@value":"130005000528"},{"@type":"CIA","@value":"130006134613"},{"@type":"CROSSREF","@value":"10.1293/tox.16.209_references_DOI_RrLiu0V4L0YkEta1ADk495yjq5V"}]}