ENHANCEMENT OF LETHAL METASTASIS OF PLASMACYTOMA IN MICE RENDERED TOLERANT TO TUMOR-ASSOCIATED TRANSPLANTATION ANTIGENS

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  • 藤原 大美
    Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School
  • 土田 哲雄
    Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School
  • 浜岡 利之
    Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School

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タイトル別名
  • Enhancement of Lethal Metastasis of Pla

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説明

The role of tumor-specific immunity in the prevention of metastasis formation was investigated. C3H/He mice were non-specifically immunosuppressed by total-body irradiation or T-cell depletion, or specifically immunodepressed by rendering them tolerant to the tumor-associated transplantation antigens (TATA) of syngeneic X5563 plasmacytoma by intravenous pretreatment with 106 7000 R X-irradiated tumor cells. The mice that were specifically immunodepressed, as well as those that were non-specifically immunosuppressed, exhibited enhanced metastasis from the intradermally inoculated primary tumor site to the spleen, though there was no significant difference in the size of the primary tumors between these immunosuppressed mice and control mice. A kinetic study of the metastasis showed no distinct difference in the amount of metastasized tumor cells in the spleens of TATA-tolerant and non-tolerant mice during the first 7 days following tumor implantation when effective tumor immunity was not detectable. However, in contrast to the persistent increase of metastasized tumor cells associated with the development of visually apparent metastatic nodules in the spleens of TATA-tolerant mice, the disappearance or decrease of metastasized tumor cells was observed in non-tolerant mice following development of effective tumor-specific immunity.<br>These results indicate that concomitant tumor-specific immunity, even if it is not enough to reject the primary tumor, is apparently able to prevent metastasis formation. Furthermore, this anti-metastatic effect of tumor-specific immunity may be ascribed to the prevention of the growth of metastasized tumor cells rather than to inhibition of the liberation or metastatic movement of tumor cells from the primary site.

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