{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680678553472.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.20632/vso.86.2_63"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"023542612"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/023542612"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I023542612"}},{"identifier":{"@type":"NAID","@value":"110009419211"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2012187963"}}],"dc:title":[{"@language":"ja","@value":"D-アミノ酸代謝酵素システムの機能と構造に関する疾患酸素学研究"},{"@language":"en","@value":"Disease-targeted Enzymology on the Function and Structure of D-Amino Acid Metabolic System"},{"@value":"D-アミノ酸代謝酵素システムの機能と構造に関する疾患酵素学研究"},{"@language":"ja-Kana","@value":"D-アミノサン タイシャ コウソ システム ノ キノウ ト コウゾウ ニ カンスル シッカン コウソガク ケンキュウ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"D-Amino acid oxidase (DAO) has been proposed to be involved in the decreased glutamatergic neurotransmission in schizophrenia and the modulation of its activity is expected to be therapeutic. Here we show the inhibitory effect of antipsychotic drugs, chlorpromazine and risperidone, on human DAO activity. In search of the pathophysiological role of DAO, we analyzed its distribution in brain. The immunoreactivity for DAO was detected in glial cells of rhombencephalon and in choroid plexus (CP) in the human brain. Furthermore, higher level of DAO expression was observed in schizophrenic CP epithelial cells. These results suggest that DAO expression level is altered in schizophrenia and the increase in DAO expression is involved in aberrant D-amino acid metabolism. In particular, gene expression of DAO in CP suggests that DAO may regulate D-amino acid concentration by modulating the cerebrospinal fluid, and may be regarded as a potential therapeutic target for schizophrenia."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658380555264","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00175564"},{"@type":"NRID","@value":"1000000175564"},{"@type":"NRID","@value":"9000391638665"},{"@type":"NRID","@value":"9000253168643"},{"@type":"NRID","@value":"9000410886158"},{"@type":"NRID","@value":"9000356516417"},{"@type":"NRID","@value":"9000347671183"},{"@type":"NRID","@value":"9000000986172"},{"@type":"NRID","@value":"9000006759940"},{"@type":"NRID","@value":"9000253182949"},{"@type":"NRID","@value":"9000016854723"},{"@type":"NRID","@value":"9000399184635"},{"@type":"NRID","@value":"9000000646573"},{"@type":"NRID","@value":"9000021821034"},{"@type":"NRID","@value":"9000410341116"},{"@type":"NRID","@value":"9000408467740"},{"@type":"NRID","@value":"9000391640979"},{"@type":"NRID","@value":"9000398801102"},{"@type":"NRID","@value":"9000326650827"},{"@type":"NRID","@value":"9000253165731"},{"@type":"NRID","@value":"9000242755846"},{"@type":"NRID","@value":"9000253165587"},{"@type":"NRID","@value":"9000253167104"},{"@type":"NRID","@value":"9000397711875"},{"@type":"NRID","@value":"9000391610030"},{"@type":"NRID","@value":"9000375857206"},{"@type":"NRID","@value":"9000391610149"},{"@type":"NRID","@value":"9000253167633"},{"@type":"NRID","@value":"9000267840729"},{"@type":"NRID","@value":"9000262060004"},{"@type":"NRID","@value":"9000391612078"},{"@type":"NRID","@value":"9000006954152"},{"@type":"NRID","@value":"9000365498748"},{"@type":"NRID","@value":"9000258320395"},{"@type":"NRID","@value":"9000404138588"},{"@type":"NRID","@value":"9000285966955"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0002644"}],"foaf:name":[{"@language":"ja","@value":"福井 清"},{"@language":"en","@value":"FUKUI Kiyoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"The University of Tokushima, The Institute for Enzyme Research, The Division of Enzyme Pathophysiology"},{"@language":"ja","@value":"徳島大学疾患酵素学研究センター・病態システム酸素学研究部門"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006386X"},{"@type":"EISSN","@value":"2424080X"},{"@type":"NDL_BIB_ID","@value":"000000020049"},{"@type":"ISSN","@value":"0006386X"},{"@type":"LISSN","@value":"0006386X"},{"@type":"NCID","@value":"AN00207833"}],"prism:publicationName":[{"@language":"ja","@value":"ビタミン"},{"@language":"en","@value":"VITAMINS"}],"dc:publisher":[{"@language":"en","@value":"THE VITAMIN SOCIETY OF JAPAN"},{"@language":"ja","@value":"公益社団法人 日本ビタミン学会"}],"prism:publicationDate":"2012","prism:volume":"86","prism:number":"2","prism:startingPage":"63","prism:endingPage":"73"},"url":[{"@id":"http://id.ndl.go.jp/bib/023542612"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I023542612"},{"@id":"https://search.jamas.or.jp/link/ui/2012187963"}],"availableAt":"2012","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=D-Amino%20acid%20oxidase","dc:title":"D-Amino acid oxidase"},{"@id":"https://cir.nii.ac.jp/all?q=glutamatergic%20neurotransmission","dc:title":"glutamatergic neurotransmission"},{"@id":"https://cir.nii.ac.jp/all?q=schizophrenia","dc:title":"schizophrenia"},{"@id":"https://cir.nii.ac.jp/all?q=glial%20cells","dc:title":"glial cells"},{"@id":"https://cir.nii.ac.jp/all?q=choroid%20plexus","dc:title":"choroid plexus"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360292618842489344","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Endogenous <scp>d</scp>‐Serine in Rat Brain: <i>N</i>‐Methyl‐<scp>d</scp>‐Aspartate Receptor‐Related Distribution and Aging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571029758592","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"<scp>d</scp>\n            -Serine is an endogenous ligand for the glycine site of the\n            <i>N</i>\n            -methyl-\n            <scp>d</scp>\n            -aspartate receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993579989248","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Inhibitory Action of Chlorpromazine on the Oxidation of D-Amino-Acid in the Diencephalon Part of the Brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996339813888","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Genetic and physiological data implicating the new human gene G72 and the gene for\n                    <scp>d</scp>\n                    -amino acid oxidase in 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amino acid oxidase"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750887087488","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"D-serine added to antipsychotics for the treatment of schizophrenia"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225863797248","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Interactions between glutamatergic and monoaminergic systems within the basal ganglia--implications for schizophrenia and Parkinson's disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700841014784","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"D-aspartate modulates melatonin synthesis in rat pinealocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572701501749760","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Human D-amino acid oxidase : an update and review"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175817725056","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Metabolism of amino-acids : deamination of amino-acids"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125770638720","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Alterations in K^+ evoked profiles of neurotransmitter and neuromodulator amino acids after focal ischemia-reperfusion"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126661383680","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular cloning and chromosomal localization of a human gene encoding D-amino-acid oxidase"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600747348480","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"D-amino acid oxidase in leukocytes : A possible D-amino-acid-linked antimicrobial system"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600747349632","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Gene expression of D-amino Acid oxidase in cultured rat astrocytes ; regional and cell type specific expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600747352448","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601674091776","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Design and properties of human D-amino acid oxidase with covalently attached flavin"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075724058368","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980076631706368","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Glycine and N-Methyl-D-Aspartate Receptors : Physiological Significance and Possible Therapeutic Applications"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980076644729088","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261551361664768","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Characterization of human D-amino acid oxidase"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261551555215360","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"In vivo and in vitro expression of porcine D-amino acid oxidase : in vitro system for the synthesis of a functional enzyme"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025677480320","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025677483392","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Crystal structure of human D-amino acid oxidase : context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026531316992","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular cloning and sequence analysis of cDNA encoding human kidney D-amino acid oxidase"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500654190720","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Effect of Risperidone on D-Amino Acid Oxidase Activity as a Hypothesis for a Novel Mechanism of Action in the Treatment of Schizophrenia"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500674736256","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Involvement of D-Aspartic Acid in the Synthesis of Testosterone in Rat Testes"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105975630901632","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia : a retrospective analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105975630902656","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Localization of the candidate gene D-Amino Acid Oxidase outside the refined 1-cM region of Spinocerebellar Ataxia 2 (SCA2)"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105975631411200","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"D-アミノ酸オキシダーゼ(EC 1.4.3.3)"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450607611904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Serine Racemase Is Predominantly Localized in Neurons in Mouse Brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387451206636416","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Formation and Breakdown of Amino-acids by Inter-molecular Transfer of the Amino Group"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387451286438912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Structural basis of D-DOPA oxidation by 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and Sequence Analysis of cDNA Encoding Porcine Kidney D-Amino Acid Oxidase"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950401478538496","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Occurrence of Pyridoxal 5'-Phosphate-Dependent Serine Racemase in Silkworm, Bombyx mori"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875537743872","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Potential pathophysiological role of D-amino acid oxidase in schizophrenia : immunohistochemical and in situ hybridization study of the expression in human and rat brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875537745280","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"D-serine added to antipsychotics for the treatment of schizophrenia"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231876382009728","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Biosynthesis of Porcine Kidney D-Amino Acid Oxidase"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2003352584"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I023542612"},{"@type":"CIA","@value":"110009419211"}]}