{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680678690944.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.20632/vso.82.3_151"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"9437520"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/9437520"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I9437520"}},{"identifier":{"@type":"NAID","@value":"110006646076"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2008179007"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"ja","@value":"親油性安定型アスコルビン酸誘導体の創製とその特性に関する研究"},{"@language":"en","@value":"Design and application of novel stable lipophilic ascorbic acid derivatives"},{"@language":"ja-Kana","@value":"シンユセイ アンテイガタ アスコルビンサン ユウドウタイ ノ ソウセイ ト ソノ トクセイ ニ カンスル ケンキュウ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"ja","@value":"L-Ascorbic acid (AsA), vitamin C, possesses many biological activities, but it readily decomposes upon exposure to heat, UV light, metal ions, and oxidants. Therefore, Yamamoto and Muto et al. have developed a stable AsA derivative, 2-O-α-D-glucopyranosyl-L-ascorbic acid (AA-2G). AA-2G has been approved by the Japanese Government as a quasi-drug principal ingredient in skin care and as a food additive and is currently being used as a medical additive in commercial cosmetics. This stable AsA derivative exhibits vitamin C activity in vitro and in vivo after enzymatic hydrolysis to AsA by α-glucosidase. Recently, we have synthesized two types of monoacylated derivatives of AA-2G, 6-O-acyl-2-O-α-D-glucopyranosyl-L-ascorbic acids having a straight-acyl chain (6-sAcyl-AA-2G) and a branched-acyl chain (6-bAcyl-AA-2G), in order to improve the bioavailability of AA-2G. These derivatives showed satisfactory stability in neutral solution comparable to that of AA-2G, and had radical scavenging activity per se. The lipophilicity of 6-sAcyl- and 6-bAcyl-AA-2G was increased with increasing length of their acyl group. 6-sAcyl- and 6-bAcyl-AA-2G with an appropriate length of the acyl chain group exhibited antiscorbutic activity in guinea pigs and skin permeability superior to that of AA-2G in a human living skin equivalent model. At a lower concentration than AA-2G, 6-sAcyl- and 6-bAcyl-AA-2G enhanced both dibutyryl cyclic AMP- and nerve growth factor-induced neurite outgrowth in PC 12 cells, antigen-specific antibody production in murine splenic cells and collagen synthesis in human skin fibroblasts, and inhibited melanogenesis in B16 mouse melanoma cells. It is necessary to metabolize the derivatives by α-glucosidase at least to demonstrate these biological activities. These results indicate that 6-sAcyl- and 6-bAcyl-AA-2G are readily available sources of AsA activity in vitro and in vivo, may be useful as an effective pharmacological agent and as a promising food additive."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276165967488","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70284081"},{"@type":"NRID","@value":"1000070284081"},{"@type":"NRID","@value":"9000005119651"},{"@type":"NRID","@value":"9000262363694"},{"@type":"NRID","@value":"9000004246650"},{"@type":"NRID","@value":"9000016821061"},{"@type":"NRID","@value":"9000388498071"},{"@type":"NRID","@value":"9000024373901"},{"@type":"NRID","@value":"9000019090039"},{"@type":"NRID","@value":"9000023284374"},{"@type":"NRID","@value":"9000021800610"},{"@type":"NRID","@value":"9000018525468"},{"@type":"NRID","@value":"9000413743496"},{"@type":"NRID","@value":"9000303163112"},{"@type":"NRID","@value":"9000414539846"},{"@type":"NRID","@value":"9000019089818"},{"@type":"NRID","@value":"9000007039315"},{"@type":"NRID","@value":"9000019090088"},{"@type":"NRID","@value":"9000018474799"},{"@type":"NRID","@value":"9000415085157"},{"@type":"NRID","@value":"9000411033792"},{"@type":"NRID","@value":"9000410312733"},{"@type":"NRID","@value":"9000005149605"},{"@type":"NRID","@value":"9000018471274"},{"@type":"NRID","@value":"9000019023161"},{"@type":"NRID","@value":"9000363279597"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0046694"}],"foaf:name":[{"@language":"ja","@value":"田井 章博"},{"@language":"en","@value":"Tai Akihiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences"},{"@language":"ja","@value":"岡山大学大学院医歯薬学総合研究科(薬学系)"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006386X"},{"@type":"EISSN","@value":"2424080X"},{"@type":"NDL_BIB_ID","@value":"000000020049"},{"@type":"ISSN","@value":"0006386X"},{"@type":"LISSN","@value":"0006386X"},{"@type":"NCID","@value":"AN00207833"}],"prism:publicationName":[{"@language":"ja","@value":"ビタミン"},{"@language":"en","@value":"VITAMINS"}],"dc:publisher":[{"@language":"en","@value":"THE VITAMIN SOCIETY OF JAPAN"},{"@language":"ja","@value":"公益社団法人 日本ビタミン学会"}],"prism:publicationDate":"2008","prism:volume":"82","prism:number":"3","prism:startingPage":"151","prism:endingPage":"160"},"reviewed":"true","url":[{"@id":"http://id.ndl.go.jp/bib/9437520"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I9437520"},{"@id":"https://search.jamas.or.jp/link/ui/2008179007"}],"availableAt":"2008","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=ascorbic%20acid","dc:title":"ascorbic acid"},{"@id":"https://cir.nii.ac.jp/all?q=AA-2G","dc:title":"AA-2G"},{"@id":"https://cir.nii.ac.jp/all?q=6-Acyl-AA-2G","dc:title":"6-Acyl-AA-2G"},{"@id":"https://cir.nii.ac.jp/all?q=stable%20lipophilic%20ascorbic%20acid%20derivative","dc:title":"stable lipophilic ascorbic acid derivative"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781951453824","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17780103"},{"@type":"JGN","@value":"JP17780103"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17780103/"}],"notation":[{"@language":"ja","@value":"真菌類由来アスコルビン酸類似体の動物における機能解明並びに生物学的利用"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1363670318740131840","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Synthesis and Characterization of a Series of Novel Monoacylated Ascorbic Acid Derivatives, 6-<i>O</i>-Acyl-2-<i>O</i>-α-<scp>d</scp>-glucopyranosyl-<scp>l</scp>-ascorbic Acids, as Skin Antioxidants"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204162082176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Protease-Catalyzed Monoacylation of 2-O-.ALPHA.-D-Glucopyranosyl-L-ascorbic Acid in Pyridine."},{"@value":"Protease-Catalyzed Monoacylation of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid in Pyridine"},{"@language":"ja-Kana","@value":"Protease Catalyzed Monoacylation of 2 O アルファ D Glucopyranosyl L ascorbic Acid in Pyridine"},{"@value":"ChemInform Abstract: Protease‐Catalyzed Monoacylation of 2‐O‐α‐D‐Glucopyranosyl‐L‐ascorbic Acid in Pyridine."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204162626432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Studies on L-Ascorbic Acid Derivatives. III. Bis (L-ascorbic acid-3, 3') phosphate and L-Ascorbic Acid 2-Phosphate"},{"@value":"Studies on l-ascorbic acid derivatives. 3. Bis(l-ascorbic acid-3,3′)phosphate and l-ascorbic acid 2-phosphate"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204163227008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Radical Scavenging Activity against 1,1-Diphenyl-2-picrylhydrazyl of Ascorbic Acid 2-Glucoside (AA-2G) and 6-Acyl-AA-2G."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204626819712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enhancement of Neurite Outgrowth in PC12 Cells Stimulated with Cyclic AMP and NGF by 6-Acylated Ascorbic Acid 2-O-.ALPHA.-Glucosides (6-Acyl-AA-2G), Novel Lipophilic Ascorbate Derivatives."},{"@value":"Enhancement of Neurite Outgrowth in PC12 Cells Stimulated with Cyclic AMP and NGF by 6-Acylated Ascorbic Acid 2-O-α-Glucosides(6-Acyl-AA-2G), Novel Lipophilic Ascorbate Derivatives"},{"@language":"ja-Kana","@value":"Enhancement of Neurite Outgrowth in PC12 Cells Stimulated with Cyclic AMP and NGF by 6 Acylated Ascorbic Acid 2 O アルファ Glucosides 6 Acyl AA 2G Novel Lipophilic Ascorbate Derivatives"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204628513408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"pH-Dependent Long-term Radical Scavenging Activity of AA-2G and 6-Octa-AA-2G against 2,2'-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) Radical Cation"},{"@value":"pH-Dependent Long-term Radical Scavenging Activity of AA-2G and 6-Octa-AA-2G against 2,2′-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) Radical Cation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205669564544","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"2-O-置換型アスコルビン酸誘導体の抗酸化特性"},{"@language":"en","@value":"Antioxidant properties of 2-O-substituted ascorbic acid derivatives"},{"@language":"ja-Kana","@value":"2-O-チカンガタ アスコルビンサン ユウドウタイ ノ コウサンカ トクセイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205669575040","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"高分子触媒によるDMF中アスコルビン酸2-グルコシドの部位選択的モノアシル化(研究論文紹介)"},{"@language":"en","@value":"Regioselective monoacylation of 2-O-α-D-glucopyranosyl-L-ascorbic acid by a polymer catalyst in N, N-dimethylformamide"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205700858624","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"新規モノアシル化アスコルビン酸誘導体6-O-dodecanoyl-2-O-α-D-glucopyranosyl-L-ascorbic acidの分子内アシル基転位と酵素的加水分解(研究論文紹介)"},{"@language":"en","@value":"Intramolecular acyl migration and enzymatic hydrolysis of a novel monoacylated ascorbic acid derivative, 6-O-dodecanoyl-2-O-α-D-glucopyranosyl-L-ascorbic acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205702158336","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"アスコルビン酸(ビタミンC)誘導体の開発動向"},{"@language":"ja-Kana","@value":"アスコルビンサン ビタミン C ユウドウタイ ノ カイハツ ドウコウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205785720576","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"1-III-2 親油性安定型アスコルビン酸誘導体6-Acyl-AA-2Gの酵素的分解速度とメラニン合成抑制作用に関る研究"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206338024704","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Male Pronuclear Formation and Blastocyst Formation Are Improved by Supplementation of Ascorbic Acid 2-O-.ALPHA.-Glucoside During In Vitro Maturation Culture of Denuded Porcine Oocytes."},{"@value":"Male Pronuclear Formation and Blastocyst Formation Are Improved by Supplementation of Ascorbic Acid -2-O-α-Glucoside During In Vitro Maturation Culture of Denuded Porcine Oocytes"},{"@language":"ja-Kana","@value":"Male Pronuclear Formation and Blastocyst Formation Are Improved by Supplementation of Ascorbic Acid 2 O アルファ Glucoside During In Vitro Maturation Culture of Denuded Porcine Oocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206473499520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Bioavailability of a Series of Novel Acylated Ascorbic Acid Derivatives, 6-O-Acyl-2-O-.ALPHA.-D-glucopyranosyl-L-ascorbic Acids, as an Ascorbic Acid Supplement in Rats and Guinea Pigs."},{"@value":"Bioavailability of a Series of Novel Acylated Ascorbic Acid Derivatives, 6-O-Acyl-2-O-α-D-glucopyranosyl-L-ascorbic Acids, as an Ascorbic Acid Supplement in Rats and Guinea Pigs"},{"@language":"ja-Kana","@value":"Bioavailability of a Series of Novel Acylated Ascorbic Acid Derivatives 6 O Acyl 2 O アルファ D glucopyranosyl L ascorbic Acids as an Ascorbic Acid Supplement in Rats and Guinea Pigs"},{"@value":"Bioavailability of a Series of Novel Acylated Ascorbic Acid Derivatives, 6-<i>O</i>-Acyl-2-<i>O</i>-α-<scp>D</scp>-glucopyranosyl-<scp>L</scp>-ascorbic Acids, as an Ascorbic Acid…"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206475403008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Vitamin C Activity in Guinea Pigs of 6-O-Acyl-2-O-.ALPHA.-D-glucopyranosyl-L-ascorbic Acids with a Branched-acyl Chain"},{"@value":"Vitamin C Activity in Guinea Pigs of 6-O-Acyl-2-O-α-D-glucopyranosyl-L-ascorbic Acids with a Branched-acyl Chain"},{"@language":"ja-Kana","@value":"Vitamin C Activity in Guinea Pigs of 6 O Acyl 2 O アルファ D glucopyranosyl L ascorbic Acids with a Branched acyl Chain"},{"@value":"Vitamin C Activity in Guinea Pigs of 6-<i>O</i>-Acyl-2-<i>O</i>-α-<scp>D</scp>-glucopyranosyl-<scp>L</scp>- ascorbic Acids with a Branched-acyl Chain"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206478387456","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"2-O-.ALPHA.-D-Glucopyranosyl-L-ascorbic Acid Scavenges 1,1-Diphenyl-2-picrylhydrazyl Radicals via a Covalent Adduct Formation"},{"@value":"2-O-α-D-glucopyranosyl-L-ascorbic acid scavenges 1,1-diphenyl-2-picrylhydrazyl radicals via a covalent adduct formation"},{"@language":"ja-Kana","@value":"2 O a D glucopyranosyl L ascorbic acid scavenges 1 1 diphenyl 2 picrylhydrazyl radicals via a covalent adduct formation"},{"@value":"2-<i>O</i>-α-<scp>D</scp>-Glucopyranosyl-<scp>L</scp>-ascorbic Acid Scavenges 1,1-Diphenyl-2-picrylhydrazyl Radicals<i>via</i>a Covalent Adduct Formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679139396224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis and Characterization of 6-O-Acyl-2-O-.ALPHA.-D-glucopyranosyl-L-ascorbic Acids with a Branched-acyl Chain."},{"@value":"Synthesis and Characterization of 6-O-Acyl-2-O-α-D-glucopyranosyl-L-ascorbic Acids with a Branched-acyl Chain"},{"@language":"ja-Kana","@value":"Synthesis and Characterization of 6 O Acyl 2 O アルファ D glucopyranosyl L ascorbic Acids with a Branched acyl Chain"},{"@value":"Synthesis and Characterization of 6‐O‐Acyl‐2‐O‐α‐D‐glucopyranosyl‐L‐ascorbic Acids with a Branched‐Acyl Chain."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679475031296","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Reduction of UVB/A-Generated Free Radicals by Sodium L-Ascorbyl-2-Phosphate in Cultured Mouse Skin"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679602974592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Long-Term Radical Scavenging Activity of AA-2G and 6-Acyl-AA-2G against 1,1-Diphenyl-2-picrylhydrazyl."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679604669568","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Characterization of the Radical-Scavenging Reaction of 2-O-Substituted Ascorbic Acid Derivatives, AA-2G, AA-2P, and AA-2S: A Kinetic and Stoichiometric Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680677571584","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"少量の水を含むDMF中におけるアスコルビン酸2-グルコシドのプロテアーゼによるモノアシル化(研究論文紹介)"},{"@language":"en","@value":"Monoacylation of 2-O-α-D-glucopyranosyl-L-ascorbic acid by protease in N,N-dimethylformamide with low water content"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680678600832","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"2.アスコルビン酸誘導体の免疫賦活作用 : サイトカイン産生および抗原特異的抗体産生(第112回ビタミンC研究委員会研究発表要旨)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681163684480","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"アスコルビン酸誘導体の製剤学的研究(第1報) : アスコルビン酸エステル類の合成およびその理化学的性質について"},{"@language":"en","@value":"Pharmaceutucal Studies on Ascorbic Acid Derivatives. I. : Syntheses of Esters of Ascorbic Acid and Their Physicochemical Properties"},{"@value":"アスコルビン酸誘導体の製剤学的研究-1-アスコルビン酸エステル類の合成およびその理化学的性質について"},{"@language":"ja-Kana","@value":"アスコルビンサン ユウドウタイ ノ セイザイガクテキ ケンキュウ 1 アスコルビンサン エステルルイ ノ ゴウセイ オヨビ ソノ リカガクテキ セイシツ ニ ツイテ"},{"@value":"Synthesis of esters of ascorbic acid and their physicochemical properties"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681438897792","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis of 2-O-.ALPHA.-D-Glucopyranosyl L-Ascorbic Acid by Cyclomaltodextrin Glucanotransferase from Bacillus stearothermophilus."},{"@value":"Synthesis of 2-O-α-d-glucopyranosyl l-ascorbic acid by cyclodextrin glucanotransferase from Bacillus stearothermophilus"},{"@value":"Synthesis of O-α-D-glucopyranosyl L-ascorbic acid by Bacillus stearothermophilus"},{"@value":"Synthesis of 2-O-α-d-glucopyranosyl l-ascorbic acid by cyclomaltodextrin glucanotransferase from Bacillus stearothermophilus"}]},{"@id":"https://cir.nii.ac.jp/crid/1390572174553625216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Annexin V assay-proven anti-apoptotic effect of ascorbic acid 2-glucoside after cold ischemia/reperfusion injury in rat liver transplantation."}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750642987520","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enhancement of developmental competence after in vitro fertilization of porcine oocytes by treatment with ascorbic acid 2-O-α-glucoside during in vitro maturation"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175573118592","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Formation of a L-ascorbic acid 2-O-α-glucoside during Kimchi fermentation"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125526539392","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibition of free radical-induced erythrocyte hemolysis by 2-O-substituted ascorbic acid derivatives"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075479961728","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Antioxidant defenses and lipid peroxidation in human blood plasma"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550456670080","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Identification of L-ascorbic acid 2-O-α-glucoside, a stable form of ascorbic acid, in Kimchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550456671360","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Antiscorbutic activity of ascorbic acid phosphate in the rhesus monkey and the guinea pig"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261551596183936","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572543027232799744","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Antiscorbutic activity of L-ascorbic acid 2-glucoside and its availability as a vitamin C supplement in normal rats and guinea pigs"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543027345341824","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"L-Ascorbic acid α-glucoside formed by regioselective transglucosylation with rat intestinal and rice seed α-glucosidases : Its improved stability and structure determination"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450363513344","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Permeation and metabolism of a series of novel lipophilic ascorbic acid derivatives, 6-O-acyl-2-O-α-D-glucopyranosyl-L-ascorbic acids with a branched-acyl chain, in a human living skin equivalent model"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950400316937216","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ascorbic acid 2-glucoside prevents sinusoidal endothelial cell apoptosis in supercooled preserved grafts in rat liver transplantation"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875293648128","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Maintenance of cold-preserved porcine hepatocyte function with UW solution and ascorbic acid-2 glucoside"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2003351764"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I9437520"},{"@type":"CIA","@value":"110006646076"},{"@type":"KAKEN","@value":"PRODUCT-10809899"}]}