{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680715935872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.14924/dermatol.111.21"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"025120391"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/025120391"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I025120391"}},{"identifier":{"@type":"NAID","@value":"10007909010"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2001170758"}}],"dc:title":[{"@language":"ja","@value":"ストレスが被毛成長に及ぼす影響について"},{"@language":"en","@value":"Effects of Overcrowding Stress on Hair Growth in Guinea Pigs"},{"@language":"ja-Kana","@value":"ストレス ガ ヒモウ セイチョウ ニ オヨボス エイキョウ ニ ツイテ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Stress is considered to be a major social problem, influencing mental and physical health. In the present study, the influences of stress on hair growth were studied in guinea pigs, who were subjected to overcrowding stress, which is considered to be a social stress. After 7 days of overcrowding stress, the back hair was shaved. At 1, 4 and 8 days after shaving, the lengths and diameters of regrowing hairs were measured, and they were microscopically observed. Furthermore, activities of several enzymes in homogenates of skin samples were measured before and after the stress treatment. Both the length and diameter of the hairs remarkably declined in the stress group compared with those of the control group (p<0.001). Microscopically, ringed stripes were seen in the affected hairs, indicating a qualitative deterioration of the hairs. Activities of all of sulfhydryl oxidase, alkaline phosphatase, and gamma-glutamyl transpeptidase in the back skin were significantly reduced in the stress group (p<0.01). These results suggest that social stress such as the overcrowding stress may influence growth and quality of hair."},{"@language":"ja","@value":"ストレスは生体に様々な影響を及ぼすことが知られている．毛髪についても，ストレスで脱毛などの影響を受けることが経験的に知られているが，学術的な研究報告はほとんど見受けられない．そこで，ストレスが被毛成長に及ぼす影響についてモルモットを用いて検討を行った．その結果，ストレスは肉眼的に被毛成長を低下させると共に，毛長，毛径の有意な低下を引き起こすことが明らかになった．加えて，ストレスを受けた動物の成長毛は筋状の模様が形成され，被毛の質的な変化も引き起こすことが確認された．また，被毛成長と関連があるといわれているγ-glutamyl transpeptidase活性，skin sulfhydryl oxidase活性，alkaline phosphatase活性に有意な低下が観察され，ストレスは生化学的にも被毛成長に影響を及ぼしていることが明らかになった．これらのことから，ストレスは被毛成長に抑制的影響を及ぼしていることが示唆された．"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282680715935874","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000655993"}],"foaf:name":[{"@language":"ja","@value":"神永 博子"},{"@language":"en","@value":"Kaminaga Hiroko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kanebo Ltd., Basic research laboratory"},{"@language":"ja","@value":"鐘紡株式会社基礎科学研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204532452865","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000674072"},{"@type":"NRID","@value":"9000254495594"}],"foaf:name":[{"@language":"ja","@value":"臼井 俊博"},{"@language":"en","@value":"Usui Toshihiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kanebo Ltd., Cosmetics laboratory"},{"@language":"ja","@value":"鐘紡株式会社化粧品研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680715935873","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000655994"}],"foaf:name":[{"@language":"ja","@value":"四宮 達郎"},{"@language":"en","@value":"Shinomiya Tatsuro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kanebo Ltd., Basic research laboratory"},{"@language":"ja","@value":"鐘紡株式会社基礎科学研究所"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0021499X"},{"@type":"EISSN","@value":"13468146"},{"@type":"NDL_BIB_ID","@value":"000000018883"},{"@type":"ISSN","@value":"0021499X"},{"@type":"LISSN","@value":"0021499X"},{"@type":"NCID","@value":"AN00196602"}],"prism:publicationName":[{"@language":"en","@value":"The Japanese Journal of Dermatology"},{"@language":"ja","@value":"日本皮膚科学会雑誌"},{"@language":"ja","@value":"日皮会誌"}],"dc:publisher":[{"@language":"en","@value":"Japanese Dermatological Association"},{"@language":"ja","@value":"公益社団法人 日本皮膚科学会"}],"prism:publicationDate":"2001","prism:volume":"111","prism:number":"1","prism:startingPage":"21","prism:endingPage":"26"},"url":[{"@id":"http://id.ndl.go.jp/bib/025120391"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I025120391"},{"@id":"https://search.jamas.or.jp/link/ui/2001170758"}],"availableAt":"2001","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=stress","dc:title":"stress"},{"@id":"https://cir.nii.ac.jp/all?q=guinea%20pigs","dc:title":"guinea pigs"},{"@id":"https://cir.nii.ac.jp/all?q=hair%20growth","dc:title":"hair growth"},{"@id":"https://cir.nii.ac.jp/all?q=enzyme%20activity","dc:title":"enzyme activity"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1361137045007080576","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Mechanism of Regulation of Human Epidermal Transglutaminase"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846030622976","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"A colorimetric assay for γ-glutamyltranspeptidase"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205043341696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evaluation of Biochemical Indices as a Hair Cycle Marker in C3H Mice."},{"@language":"ja-Kana","@value":"Evaluation of Biochemical Indices as a"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205739987072","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ストレスと皮膚―過密ストレスモデルによる皮膚生理学的変化―"}]},{"@id":"https://cir.nii.ac.jp/crid/1520291855656940672","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Gamma Coat〔125I〕Cortisolキットによる血中,尿中cortisol測定法の検討"},{"@language":"ja-Kana","@value":"Gamma Coat 125I Cortisol キット ニヨル 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