{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680716074368.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.14924/dermatol.113.1695"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"025121329"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/025121329"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I025121329"}},{"identifier":{"@type":"NAID","@value":"130004714682"}},{"identifier":{"@type":"NAID","@value":"10011933142"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2004075383"}}],"dc:title":[{"@language":"ja","@value":"水疱性類天疱瘡の病勢の指標についての多角的検討―臨床症状，血清IgE値，好酸球数，抗基底膜抗体価，抗BP180 NC16a抗体価―"},{"@language":"en","@value":"Monitoring the Disease Activity in Patients with Bullous Pemphigoid from Different Angles"},{"@language":"ja-Kana","@value":"スイホウセイルイ テンポウソウ ノ ビョウセイ ノ シヒョウ ニ ツイテ ノ タカクテキ ケントウ : リンショウ ショウジョウ,ケッセイ IgEチ,コウサンキュウスウ,コウキテイマク コウタイカ,コウBP180 NC16a コウタイカ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Bullous pemphgoid (BP) is an acquired autoimmune subepidermal blisterng disease, which shows various symptoms, including bulla, polymorphic erythema, and pruritus. There is often an eosinophilia and raised serum IgE. The target antigens are hemidesmosomal cytoplasmic BP230 and transmembrane BP180 proteins. In this study, we investigated the correlation among the clinical symptoms, serum IgE, the eosinophil count, indirect immunofluorescence titer, and BP180NC16a scores measured by enzyme-linked immunosorbent assay (ELISA). With clinical improvement, all of these values decrease ; the BP180NC16a scores and the eosinophil count were particularly closely correlated. At the disease relapsed, the BP180NC16a score was the most sensitive indicator. In patients exhibiting high levels of BP180NC16a scores greater than 150 by regular ELISA, we again performed ELISA with appropriate dilutions and obtained true index values that exhibited a better correlation with disease activity. During plasma exchange, we could detect the reduction of the pathogenic anti-BP180NC16a autoantibody by using ELISA. These findings indicate that BP180NC16a ELISA can be valuable not only for the diagnosis of patients with BP but also for monitoring disease activity."},{"@language":"ja","@value":"近年，BP180 NC16a・ELISA法の導入により高い感度，特異性を有する類天疱瘡の診断および病勢のモニタリングが確立されつつある．しかし，類天疱瘡では多彩な臨床所見を呈し，水疱発症機序も複雑である．そこで，類天疱瘡患者8例について治療経過中，臨床症状（水疱，紅斑，そう痒），血清IgE値，好酸球数，Indirect immunofluorescence（IIF）titerおよび抗BP180 NC16a抗体価の推移について解析し，それらの臨床的意義を検討した．臨床症状の軽快に伴い，ほぼ全例で血清IgE値，好酸球数，IIF titerおよび抗BP180 NC16a抗体価の低下を認めた．そのうち，好酸球数と抗BP180 NC16a抗体価はより鋭敏に，一方血清IgE値とIIF titerはやや症状に遅れて低下する傾向があった．また，症状の再燃時に好酸球数，IIF titerおよび抗BP180 NC16a抗体価の上昇を認めた例が散見されたが，特にELISAスコアが最も鋭敏であった．ELISAスコアとIIF titerを比較した際，ELISAスコア陽性/IIF titer陰性となる例とELISAスコア陰性/IIF titer陽性となる例を認めた．その理由として，前者は感度の違い，後者は認識する自己抗体の違いによるものであると推察した．通常の100倍希釈血清でELISAスコアが高値（Index値＞150）を示した各症例において，至適希釈率および真の抗体価を求めた上でモニタリングしたところ，的確に病勢を把握することが可能であった．また，血漿交換療法を施行した難治性類天疱瘡患者に対して，その前・後においてELISAスコアの変動を解析したところ，病因となる血中自己抗体（抗BP180 NC16a抗体）の除去の確認が可能であり，その併用に伴う具体的な有用性が示された．これらの結果より，類天疱瘡の治療に際して多彩な臨床症状を念頭に置きながら，抗BP180 NC16a抗体価を中心として，血清IgE値，好酸球数，IIF titerを定期的に測定することは有意義であると考えた．"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282680716074368","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000273027064"}],"foaf:name":[{"@language":"ja","@value":"岸本 和裕"},{"@language":"en","@value":"Kishimoto Kazuhiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Dermatology, Takeda General Hospital"},{"@language":"ja","@value":"竹田綜合病院皮膚科"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801199077248","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60175502"},{"@type":"NRID","@value":"1000060175502"},{"@type":"NRID","@value":"9000345199054"},{"@type":"NRID","@value":"9000273027146"},{"@type":"NRID","@value":"9000273007417"},{"@type":"NRID","@value":"9000273006687"},{"@type":"NRID","@value":"9000256823038"},{"@type":"NRID","@value":"9000313621325"},{"@type":"NRID","@value":"9000273009156"},{"@type":"NRID","@value":"9000359876918"},{"@type":"NRID","@value":"9000022014740"},{"@type":"NRID","@value":"9000391738843"},{"@type":"NRID","@value":"9000307263312"},{"@type":"NRID","@value":"9000283574903"},{"@type":"NRID","@value":"9000367405706"},{"@type":"NRID","@value":"9000391672450"},{"@type":"NRID","@value":"9000398153940"},{"@type":"NRID","@value":"9000003770394"},{"@type":"NRID","@value":"9000003675217"},{"@type":"NRID","@value":"9000004636118"},{"@type":"NRID","@value":"9000391671694"},{"@type":"NRID","@value":"9000323310478"},{"@type":"NRID","@value":"9000316198848"},{"@type":"NRID","@value":"9000293503724"},{"@type":"NRID","@value":"9000398170445"},{"@type":"NRID","@value":"9000345303287"},{"@type":"NRID","@value":"9000256128142"},{"@type":"NRID","@value":"9000240099588"},{"@type":"NRID","@value":"9000273008820"},{"@type":"NRID","@value":"9000283115834"},{"@type":"NRID","@value":"9000411378777"},{"@type":"NRID","@value":"9000345254905"},{"@type":"NRID","@value":"9000414863426"},{"@type":"NRID","@value":"9000391671871"},{"@type":"NRID","@value":"9000345397375"},{"@type":"NRID","@value":"9000413888405"},{"@type":"NRID","@value":"9000257937889"},{"@type":"NRID","@value":"9000267849006"},{"@type":"NRID","@value":"9000240240771"},{"@type":"NRID","@value":"9000242142547"},{"@type":"NRID","@value":"9000402221435"},{"@type":"NRID","@value":"9000270299603"},{"@type":"NRID","@value":"9000345397478"},{"@type":"NRID","@value":"9000257977477"},{"@type":"NRID","@value":"9000402798573"},{"@type":"NRID","@value":"9000356660559"},{"@type":"NRID","@value":"9000399565940"},{"@type":"NRID","@value":"9000273007869"},{"@type":"NRID","@value":"9000283575057"},{"@type":"NRID","@value":"9000309991071"},{"@type":"NRID","@value":"9000345446266"},{"@type":"NRID","@value":"9000345397015"},{"@type":"NRID","@value":"9000273027065"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0134700"}],"foaf:name":[{"@language":"ja","@value":"中村 晃一郎"},{"@language":"en","@value":"Nakamura Koichiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Dermatology, Fukushima Medical University of Medicine"},{"@language":"ja","@value":"福島県立医科大学医学部皮膚科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658352945920","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50001920"},{"@type":"NRID","@value":"1000050001920"},{"@type":"NRID","@value":"9000345199051"},{"@type":"NRID","@value":"9000273027147"},{"@type":"NRID","@value":"9000273007418"},{"@type":"NRID","@value":"9000016184617"},{"@type":"NRID","@value":"9000003752522"},{"@type":"NRID","@value":"9000259843908"},{"@type":"NRID","@value":"9000273007210"},{"@type":"NRID","@value":"9000257930479"},{"@type":"NRID","@value":"9000259848970"},{"@type":"NRID","@value":"9000258530838"},{"@type":"NRID","@value":"9000257931122"},{"@type":"NRID","@value":"9000259846720"},{"@type":"NRID","@value":"9000242746094"},{"@type":"NRID","@value":"9000398153945"},{"@type":"NRID","@value":"9000266902108"},{"@type":"NRID","@value":"9000025051088"},{"@type":"NRID","@value":"9000257931029"},{"@type":"NRID","@value":"9000259844929"},{"@type":"NRID","@value":"9000266901590"},{"@type":"NRID","@value":"9000022032685"},{"@type":"NRID","@value":"9000258229605"},{"@type":"NRID","@value":"9000273008816"},{"@type":"NRID","@value":"9000273007294"},{"@type":"NRID","@value":"9000273006757"},{"@type":"NRID","@value":"9000257930816"},{"@type":"NRID","@value":"9000259844819"},{"@type":"NRID","@value":"9000273007249"},{"@type":"NRID","@value":"9000258530812"},{"@type":"NRID","@value":"9000022032328"},{"@type":"NRID","@value":"9000391672658"},{"@type":"NRID","@value":"9000259845721"},{"@type":"NRID","@value":"9000258532098"},{"@type":"NRID","@value":"9000014374002"},{"@type":"NRID","@value":"9000022019539"},{"@type":"NRID","@value":"9000273027386"},{"@type":"NRID","@value":"9000266902595"},{"@type":"NRID","@value":"9000022028546"},{"@type":"NRID","@value":"9000022032055"},{"@type":"NRID","@value":"9000346932712"},{"@type":"NRID","@value":"9000259847842"},{"@type":"NRID","@value":"9000257933555"},{"@type":"NRID","@value":"9000273027066"},{"@type":"NRID","@value":"9000257930906"},{"@type":"NRID","@value":"9000259850822"},{"@type":"NRID","@value":"9000259849298"}],"foaf:name":[{"@language":"ja","@value":"金子 史男"},{"@language":"en","@value":"Kaneko Fumio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Dermatology, Fukushima Medical University of Medicine"},{"@language":"ja","@value":"福島県立医科大学医学部皮膚科学教室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0021499X"},{"@type":"EISSN","@value":"13468146"},{"@type":"NDL_BIB_ID","@value":"000000018883"},{"@type":"ISSN","@value":"0021499X"},{"@type":"LISSN","@value":"0021499X"},{"@type":"NCID","@value":"AN00196602"}],"prism:publicationName":[{"@language":"en","@value":"The Japanese Journal of Dermatology"},{"@language":"ja","@value":"日本皮膚科学会雑誌"},{"@language":"ja","@value":"日皮会誌"}],"dc:publisher":[{"@language":"en","@value":"Japanese Dermatological Association"},{"@language":"ja","@value":"公益社団法人 日本皮膚科学会"}],"prism:publicationDate":"2003","prism:volume":"113","prism:number":"11","prism:startingPage":"1695","prism:endingPage":"1710"},"url":[{"@id":"http://id.ndl.go.jp/bib/025121329"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I025121329"},{"@id":"https://search.jamas.or.jp/link/ui/2004075383"}],"availableAt":"2003","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=bullous%20pemphigoid","dc:title":"bullous pemphigoid"},{"@id":"https://cir.nii.ac.jp/all?q=BP180NC16a%20ELISA","dc:title":"BP180NC16a ELISA"},{"@id":"https://cir.nii.ac.jp/all?q=autoimmune%20bullous%20disease","dc:title":"autoimmune bullous disease"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145166263808","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Rabbits Immunized with a Peptide Encoded for by the 230-kD bullous Pemphigoid Antigen cDNA Develop an Enhanced Inflammatory Response to UVB Irradiation: A Potential Animal Model for Bullous Pemphigoid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094889224704","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"IgG4 and IgE are the major immunoglobulins targeting the NC 16A domain of BP 180 in bullous pemphigoid: Serum levels of these immunoglobulins reflect disease activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096374144768","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"IgE and its related phenomena in bullous pemphigoid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569515747072","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Subclass Distribution of IgG Autoantibodies in Bullous Pemphigoid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570250078720","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Pathogenicity of the intercellular antibodies of pemphigus and their periodic removal from the circulation by plasmapheresis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518584708352","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Detection of Pemphigus Vulgaris and Pemphigus Foliaceus Antigens by Immunoblot Analysis Using Different Antigen Sources"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996094033280","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"A Highly Sensitive Enzyme-Linked Immunosorbent Assay for the Detection of Circulating Anti-BP180 Autoantibodies in Patients with Bullous Pemphigoid"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843419092736","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Cellular events leading to blister formation in bullous pemphigoid"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319065980032","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Cloning and Primary Structural Analysis of the Bullous Pemphigoid Autoantigen BP180"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205739374208","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"水疱性類天疱瘡患者における水疱内容液中の抗BP180 NC16a抗体価測定の有用性についての検討"},{"@language":"en","@value":"BP180 NC16a ELISA Using Bullous Fluid Samples as a Diagnostic Tool for Bullous Pemphigoid"},{"@language":"ja-Kana","@value":"スイホウセイルイ テンポウソウ カンジャ ニ オケル スイホウ ナイヨウエキ チュウ ノ コウBP180NC16a コウタイカ ソクテイ ノ ユウヨウセイ ニ ツイテ ノ ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205740399104","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"尋常性天疱瘡，水疱性類天疱瘡に対する血漿交換療法の評価―順天堂大学皮膚科42症例のまとめ―"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205746642432","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Plasma Exchange in the Treatment of Pemphigus vulgaris"},{"@language":"ja","@value":"天疱瘡の血漿交換療法"},{"@language":"ja-Kana","@value":"テンホウソウ ノ ケッショウ コウカン リョウホウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680713835520","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Case of Bullous Pemphigoid Successfully Treated with Intravenous Immunoglobulin"},{"@language":"ja","@value":"免疫グロブリン大量静注療法が著効した水疱性類天疱瘡の1例"},{"@language":"ja-Kana","@value":"メンエキ グロブリン タイリョウ ジョウチュウ リョウホウ ガ チョコウシタ スイホウセイルイ テンホウソウ ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680715496576","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"難治性天疱瘡に対する血漿交換療法の有用性に関する検討　抗デスモグレイン抗体価測定の臨床的意義について"},{"@language":"en","@value":"Monitering of Circulating Autoantibodies to Desmogleins in Patients with Pemphigus during Treatment with Double Filtration Plasmapheresis Is Useful"},{"@language":"ja-Kana","@value":"ナンチセイ テンポウソウ ニ タイスル ケッショウ コウカン リョウホウ ノ ユウヨウセイ ニ カンスル ケントウ : コウデスモグレイン コウタイカ ソクテイ ノ リンショウテキ イギ ニ ツイテ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680716033792","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ELISA法を用いて測定した天疱瘡患者血清中の抗デスモグレイン（Dsg）抗体価と臨床症状との相関について：抗体価が高値（Index値150以上）を示した患者群における血清希釈系列を用いた抗Dsg抗体価の推移に関する検討"},{"@language":"en","@value":"A Trial of Monitoring the Disease Activity in Patients with Pemphigus Associated with a High Titer of Desmoglein Autoantibodies by the Enzyme-Linked Immunosorbent Assays"},{"@language":"ja-Kana","@value":"ELISAホウ オ モチイテ ソクテイ シタ テンポウソウ カンジャ ケッセイ チュウ ノ コウデスモグレイン(Dsg)コウタイカ ト リンショウ ショウジョウ ト ノ ソウカン ニ ツイテ : コウタイカ ガ タカネ(Indexチ 150 イジョウ)オ シメシタ カンジャグン ニ オケル ケッセイ キシャク ケイレツ オ モチイタ コウDsg コウタイカ ノ スイイ ニ カンスル ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750015283200","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Production of the entire extracellular domain of BP 180 (type XVII collagen) by baculovirus expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291224991998336","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Monitoring disease activity in pemphigus with enzyme-linked immunosorbent assay using recombinant desmoglein 1 and 3"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291224991999616","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"皮膚科領域特-天疱瘡および類天疱瘡"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699968706048","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An eosinophil chemotactic factor present in blister fluids of bullous pemphigoid patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699968707328","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical significance of enzyme-linked immunosorbent assay for the detection of circulating anti-180 autoantibodies in patients with bulous pemphigoid"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699968708608","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Serum level of autoantibodies in patients with bullous pemphigoid"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572701216271872","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Diagnostic value of indirect immunofluorescence on sodium chloride-split skin in differential diagnosis of subepidermal autoimmune bullous dermatoses"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417124892462464","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"皮膚科領域, 特に尋常性天疱瘡における血漿交換療法"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599875551104","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"92-kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of 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