{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680739699328.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2131/fts.1.63"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/fts/1/2/1_63/_pdf"}},{"identifier":{"@type":"NAID","@value":"130005083336"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2015195058"}}],"dc:title":[{"@language":"en","@value":"A 4-week oral toxicity study of L-alanine in rats with a recovery period of 2 weeks"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"To investigate the safety of L-alanine, male and female Sprague-Dawley strain SPF rats [Crj:CD(SD)IGS] were administered L-alanine at 2,000 mg/kg/day by gavage for 4 weeks. After the end of the dosing period, reversibility was assessed following a 2-week recovery period. In the results, there were no toxicologically significant changes caused by L-alanine in general condition, body weight, food consumption, ophthalmology, hematology, blood chemistry, organ weight or at necropsy. In urinalysis, increased number of animals showing urine protein-positive or phosphate salt was observed in males and females. In addition, urine volume was significantly increased in males. In histopathological examination, squamous cell hyperplasia in the limiting ridge in the stomach was observed in males and females. These changes were reduced or no longer observed after the 2-week recovery period and thus were reversible changes. These results suggest that repeated oral administration of L-alanine at 2,000 mg/kg/day for 4 weeks is well tolerated in male and female rats."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282680739699332","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000293841034"}],"foaf:name":[{"@language":"en","@value":"Aoki Mami"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680739699330","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000293841035"}],"foaf:name":[{"@language":"en","@value":"Mochizuki Masahiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Gotemba Laboratory, BoZo Research Center Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680739699331","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000293841036"}],"foaf:name":[{"@language":"en","@value":"Okamura Toshiya"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Gotemba Laboratory, BoZo Research Center Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680739699328","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000293841037"}],"foaf:name":[{"@language":"en","@value":"Hatayama Kazuhisa"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Gotemba Laboratory, BoZo Research Center Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680739699329","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000293841038"}],"foaf:name":[{"@language":"en","@value":"Nakamura Atsushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Gotemba Laboratory, BoZo Research Center Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680739699333","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000293841039"}],"foaf:name":[{"@language":"en","@value":"Morishita Koji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Public Relations Department, KYOWA HAKKO BIO CO., LTD."}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"2189115X"}],"prism:publicationName":[{"@language":"ja","@value":"Fundamental Toxicological Sciences"},{"@language":"en","@value":"Fundamental Toxicological Sciences"},{"@language":"ja","@value":"Fundam. Toxicol. Sci."},{"@language":"en","@value":"Fundam. Toxicol. Sci."}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society of Toxicology"},{"@language":"ja","@value":"一般社団法人 日本毒性学会"}],"prism:publicationDate":"2014","prism:volume":"1","prism:number":"2","prism:startingPage":"63","prism:endingPage":"72"},"reviewed":"false","url":[{"@id":"https://www.jstage.jst.go.jp/article/fts/1/2/1_63/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2015195058"}],"availableAt":"2014","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=L-Alanine","dc:title":"L-Alanine"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=General%20toxicity","dc:title":"General toxicity"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1361137043631889664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Development of a Free Amino Acid Diet for the Growing Chick"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519842218624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Studies on the metabolism of amino acids and related compounds in vivo. I. Toxicity of essential amino acids, individually and in mixtures, and the protective effect of l-arginine"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845180219648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Alanine: A toxicity study*1"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794323305856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dietary D-Amino Acids"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204413751552","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparisons of L-cysteine and D-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2000655309"},{"@type":"CROSSREF","@value":"10.2131/fts.1.63"},{"@type":"CIA","@value":"130005083336"},{"@type":"CROSSREF","@value":"10.1293/tox.2017-0002_references_DOI_SR2kWCaDFZka305YogkaYeikyOh"}]}