PARTICIPATION OF ASCORBIC ACID IN THE FORMATION OF TYROSINE MELANIN

  • TAKENOUCHI Katsu
    Department of Dermatology, School of Medicine, Chiba University
  • IMAI Riichi
    Department of Dermatology, School of Medicine, Chiba University
  • ASO Kazuo
    Department of Dermatology, School of Medicine, Chiba University
  • OKAMOTO Shoji
    Department of Dermatology, School of Medicine, Chiba University
  • KOBAYASHI Takemasa
    Department of Dermatology, School of Medicine, Chiba University
  • UTSUMI Ko
    Department of Dermatology, School of Medicine, Chiba University
  • SAITO Somei
    Department of Dermatology, School of Medicine, Chiba University
  • TAKEUCHI Itaru
    Department of Dermatology, School of Medicine, Chiba University
  • KONDO Shozo
    Department of Dermatology, School of Medicine, Chiba University
  • KAWASE Kenji
    Department of Dermatology, School of Medicine, Chiba University
  • TAKIZAWA Hideo
    Department of Dermatology, School of Medicine, Chiba University

Bibliographic Information

Other Title
  • 皮膚色素異常沈着症とビタミンCについて : (I)メラニン生成とビタミンCの関係
  • 皮膚色素異常沈着症とビタミンCについて-1-
  • ヒフ シキソ イジョウ チンチャクショウ ト ビタミン C ニ ツイテ 1

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Description

As preliminary studies on the clinical application for the treatment of pigmented dermatosis with a massive doses of ascorbic acid (1〜2g), participations of ascorbic acid in the formation of melanin as well as absorption and excretion of the vitamin in man and experimental animal were investigated. Ascorbic acid inhibited melanin formation in tyrosine-tyrosinase system by its reducing property, and the reaction did not proceed untill all ascorbic acid in the reaction system was oxidized to dehydroascorbic acid. The minimum amount of complete inhibition of melanin formation was 0.5μM. The amounts of ascorbic acid in the skin after intramuscular injection of 300 mg to guinea pig or rabbit were 3.0μM. There was no marked difference in amount between pigmented and nonpigmented skin. The level of ascorbic acid did not precede than 2.4〜2.6mg%, whenever massive amount was given orally. Urinary excretion of ascorbic acid was 20% of the amount administered after daily oral administration of 2g for one month.

Journal

  • VITAMINS

    VITAMINS 28 (6), 501-507, 1963

    THE VITAMIN SOCIETY OF JAPAN

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