{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680786017280.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.20632/vso.38.1_41"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"8424542"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/8424542"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I8424542"}},{"identifier":{"@type":"NAID","@value":"110002859475"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1969050100"}}],"dc:title":[{"@language":"ja","@value":"ビタミンB_1類の安定性にかんする研究 : (VIII)含水エタノール溶液中のEthoxycarbonylthiamine類の安定性"},{"@language":"en","@value":"STUDIES ON THE STABILITY OF THIAMINE AND ITS MODIFIED COMPOUNDS : (VIII) STABILITIES OF ETHOXYCARBONYLTHIAMINES IN AQUEOUS ETHANOL"},{"@value":"ビタミンB1類の安定性にかんする研究-8-含水エタノール溶液中のEthoxycarbonylthiamine類の安定性"},{"@language":"ja-Kana","@value":"ビタミン B1ルイ ノ アンテイセイ ニ カンスル ケンキュウ 8 ガンスイ エタノール ヨウエキ チュウ ノ Ethoxycarbonylthiamineルイ ノ アンテイセイ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Examinations were made on the stabilities of thiamine (B_1) and three ethoxycarbonyl-thiamines (3mM) in aqueous ethanol of different concentrations ranging from 20 to 99.5% (v/v) at 100℃ in ampules in comparison with those in aqueous solution. Each of the compounds was degraded by a pseudo first-order reaction, regardless of the presence of ethanol. A decrease in stability of B_1 was found by increasing the ethanol concentration, the rate showing a maximum in 80% ethanol. O-Ethoxycarbonylthiamine (OCET) in aqueous ethanol was decomposed showing a maximum rate in 60〜80% ethanol, where B_1 was not given even after 10 hours, while in the aqueous solution, the amount of B_1 produced from OCET was 1.7%. An increase in stability of S-ethoxycarbonylthiamine was found in proportion to the increase in ethanol concentration. The decomposition rate constant in 99.5% ethanol was less than 1/20 of the rate in aqueous solution. The degradation rate of O, S-bis (ethoxycarbonyl) thiamine in aqueous solution was little influenced by the addition of ethanol, but the percentages of the formation of thiochrome-reaction-positive compounds decreased with the increase of ethanol concentration."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001205761043072","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004457153"},{"@type":"NRID","@value":"9000392652668"},{"@type":"NRID","@value":"9000392652776"},{"@type":"NRID","@value":"9000392639145"}],"foaf:name":[{"@language":"ja","@value":"稲津 邦平"},{"@language":"en","@value":"INAZU Kunihei"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Shionogi Research Laboratory, Shionogi & Co., Ltd."},{"@language":"ja","@value":"塩野義製薬株式会社研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680786017280","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"砂川 成代"},{"@language":"en","@value":"SUNAGAWA Shigeyo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Shionogi Research Laboratory, Shionogi & Co., Ltd."},{"@language":"ja","@value":"塩野義製薬株式会社研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205761041282","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004454335"}],"foaf:name":[{"@language":"ja","@value":"山本 隆一"},{"@language":"en","@value":"YAMAMOTO Ryuichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Shionogi Research Laboratory, Shionogi & Co., Ltd."},{"@language":"ja","@value":"塩野義製薬株式会社研究所"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006386X"},{"@type":"EISSN","@value":"2424080X"},{"@type":"NDL_BIB_ID","@value":"000000020049"},{"@type":"ISSN","@value":"0006386X"},{"@type":"LISSN","@value":"0006386X"},{"@type":"NCID","@value":"AN00207833"}],"prism:publicationName":[{"@language":"ja","@value":"ビタミン"},{"@language":"en","@value":"VITAMINS"}],"dc:publisher":[{"@language":"en","@value":"THE VITAMIN SOCIETY OF JAPAN"},{"@language":"ja","@value":"公益社団法人 日本ビタミン学会"}],"prism:publicationDate":"1968","prism:volume":"38","prism:number":"1","prism:startingPage":"41","prism:endingPage":"44"},"url":[{"@id":"http://id.ndl.go.jp/bib/8424542"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I8424542"},{"@id":"https://search.jamas.or.jp/link/ui/1969050100"}],"availableAt":"1968","dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2003646377"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I8424542"},{"@type":"CIA","@value":"110002859475"}]}