{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282680810659968.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.20632/vso.69.2_115"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"3605979"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/3605979"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I3605979"}},{"identifier":{"@type":"NAID","@value":"110002848150"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1995235142"}}],"dc:title":[{"@language":"ja","@value":"健康成人に Thiamin Tetrahydrofurfuryl Disulfide 含有製剤を単回および分割経口投与したときのビタミンB_1の体内動態 : 高齢者における総合ビタミン剤長期服用効果"},{"@language":"en","@value":"Changes in Blood Concentrations and Urinary Excretion of Vitamin B_1 after either Single or Divided Oral Administration of Tablets Containing Thiamin Tetrahydrofurfuryl Disulfide"},{"@value":"健康成人にThiamin Tetrahydrofurfuryl Disulfide含有製剤を単回および分割経口投与したときのビタミンB1の体内動態"},{"@language":"ja-Kana","@value":"ケンコウ セイジン ニ Thiamin Tetrahydrofurfuryl"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Bioavailability of preparations of thiamin tetrahydrofurfryl disulfide (TTFD) was examined in 6 healthy male adult volunteers. 1. No significant difference was observed in the AUC and urinary excretion of vitamin B_1 in the daily 100 mg TTFD administration between single and twice divided dose. 2. C_<max> AUC and urinary excretion of vitamin B_1 were two fold higher at orally once administration of 100mg of TTFD as compared with those at the 50 mg administration. Those were in dose-dependent manner and did not differ between difference of the tablets. 3. There were no differences in its pharmacokinetic parameters between postprandial administration of 100 mg TTFD and the administration at fasting, but variables in blood levels with respect to the absorption seemed to be smaller in postprandial administration than in fasting administration."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658334785152","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80025593"},{"@type":"NRID","@value":"1000080025593"},{"@type":"NRID","@value":"9000002754519"},{"@type":"NRID","@value":"9000363298181"},{"@type":"NRID","@value":"9000020524829"},{"@type":"NRID","@value":"9000022204001"},{"@type":"NRID","@value":"9000022200434"},{"@type":"NRID","@value":"9000020241508"},{"@type":"NRID","@value":"9000022195961"},{"@type":"NRID","@value":"9000020890653"},{"@type":"NRID","@value":"9000020874045"},{"@type":"NRID","@value":"9000254363731"},{"@type":"NRID","@value":"9000006210361"},{"@type":"NRID","@value":"9000003214961"},{"@type":"NRID","@value":"9000020234122"},{"@type":"NRID","@value":"9000020580741"},{"@type":"NRID","@value":"9000022203850"},{"@type":"NRID","@value":"9000022203449"},{"@type":"NRID","@value":"9000008917058"},{"@type":"NRID","@value":"9000008349169"},{"@type":"NRID","@value":"9000365024879"},{"@type":"NRID","@value":"9000020217221"},{"@type":"NRID","@value":"9000020255212"},{"@type":"NRID","@value":"9000253672056"},{"@type":"NRID","@value":"9000392045484"},{"@type":"NRID","@value":"9000009761559"},{"@type":"NRID","@value":"9000241439321"},{"@type":"NRID","@value":"9000004107034"},{"@type":"NRID","@value":"9000020255740"},{"@type":"NRID","@value":"9000020593974"},{"@type":"NRID","@value":"9000022200397"},{"@type":"NRID","@value":"9000020889059"},{"@type":"NRID","@value":"9000010123218"},{"@type":"NRID","@value":"9000020053648"},{"@type":"NRID","@value":"9000020579233"},{"@type":"NRID","@value":"9000020493620"},{"@type":"NRID","@value":"9000020496179"},{"@type":"NRID","@value":"9000022201733"},{"@type":"NRID","@value":"9000022196919"},{"@type":"NRID","@value":"9000022197059"},{"@type":"NRID","@value":"9000020889047"},{"@type":"NRID","@value":"9000020221863"},{"@type":"NRID","@value":"9000254301465"},{"@type":"NRID","@value":"9000237772582"},{"@type":"NRID","@value":"9000020270022"},{"@type":"NRID","@value":"9000020567146"},{"@type":"NRID","@value":"9000021431680"},{"@type":"NRID","@value":"9000022202100"},{"@type":"NRID","@value":"9000022197350"},{"@type":"NRID","@value":"9000014108585"},{"@type":"NRID","@value":"9000004029517"},{"@type":"NRID","@value":"9000023496133"},{"@type":"NRID","@value":"9000021407826"},{"@type":"NRID","@value":"9000020567407"},{"@type":"NRID","@value":"9000022199197"},{"@type":"NRID","@value":"9000021859035"},{"@type":"NRID","@value":"9000252888704"},{"@type":"NRID","@value":"9000399447547"},{"@type":"NRID","@value":"9000364914907"},{"@type":"NRID","@value":"9000020174813"},{"@type":"NRID","@value":"9000020491275"},{"@type":"NRID","@value":"9000020566430"},{"@type":"NRID","@value":"9000020131515"},{"@type":"NRID","@value":"9000020158253"},{"@type":"NRID","@value":"9000022203881"},{"@type":"NRID","@value":"9000020260419"},{"@type":"NRID","@value":"9000020434803"},{"@type":"NRID","@value":"9000020162333"},{"@type":"NRID","@value":"9000022197543"},{"@type":"NRID","@value":"9000022197346"},{"@type":"NRID","@value":"9000022201805"},{"@type":"NRID","@value":"9000403323642"},{"@type":"NRID","@value":"9000020214366"},{"@type":"NRID","@value":"9000022202829"},{"@type":"NRID","@value":"9000020182656"},{"@type":"NRID","@value":"9000022198831"},{"@type":"NRID","@value":"9000020195548"},{"@type":"NRID","@value":"9000020864944"},{"@type":"NRID","@value":"9000020864826"},{"@type":"NRID","@value":"9000022196296"},{"@type":"NRID","@value":"9000252914428"},{"@type":"NRID","@value":"9000020130530"},{"@type":"NRID","@value":"9000020221335"},{"@type":"NRID","@value":"9000020897056"},{"@type":"NRID","@value":"9000020179944"},{"@type":"NRID","@value":"9000020156425"},{"@type":"NRID","@value":"9000020430993"},{"@type":"NRID","@value":"9000020258907"},{"@type":"NRID","@value":"9000022202305"},{"@type":"NRID","@value":"9000253644263"},{"@type":"NRID","@value":"9000008353534"},{"@type":"NRID","@value":"9000010052850"},{"@type":"NRID","@value":"9000024360385"},{"@type":"NRID","@value":"9000020236223"},{"@type":"NRID","@value":"9000020135854"},{"@type":"NRID","@value":"9000022198551"},{"@type":"NRID","@value":"9000023608111"},{"@type":"NRID","@value":"9000020221354"},{"@type":"NRID","@value":"9000020011885"},{"@type":"NRID","@value":"9000020007503"},{"@type":"NRID","@value":"9000017520312"}],"foaf:name":[{"@language":"ja","@value":"糸川 嘉則"},{"@language":"en","@value":"ITOKAWA Yoshinon"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Graduate School of Medicine, Kyoto University"},{"@language":"ja","@value":"京都大学大学院医学研究科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205339646980","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004455781"},{"@type":"NRID","@value":"9000020338072"}],"foaf:name":[{"@language":"ja","@value":"中村 幹"},{"@language":"en","@value":"NAKAMURA Tsuyoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Clinical Pharmacology Center, Daiichi Hospital"},{"@language":"ja","@value":"東光会第一病院臨床薬理センター"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006386X"},{"@type":"EISSN","@value":"2424080X"},{"@type":"NDL_BIB_ID","@value":"000000020049"},{"@type":"ISSN","@value":"0006386X"},{"@type":"LISSN","@value":"0006386X"},{"@type":"NCID","@value":"AN00207833"}],"prism:publicationName":[{"@language":"ja","@value":"ビタミン"},{"@language":"en","@value":"VITAMINS"}],"dc:publisher":[{"@language":"en","@value":"THE VITAMIN SOCIETY OF JAPAN"},{"@language":"ja","@value":"公益社団法人 日本ビタミン学会"}],"prism:publicationDate":"1995","prism:volume":"69","prism:number":"2","prism:startingPage":"115","prism:endingPage":"121"},"url":[{"@id":"http://id.ndl.go.jp/bib/3605979"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I3605979"},{"@id":"https://search.jamas.or.jp/link/ui/1995235142"}],"availableAt":"1995","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=human%20bioavailability","dc:title":"human bioavailability"},{"@id":"https://cir.nii.ac.jp/all?q=thiamin%20tetrahydrofurfuryl%20disulfide","dc:title":"thiamin tetrahydrofurfuryl disulfide"},{"@id":"https://cir.nii.ac.jp/all?q=blood%20thiamin%20concentration","dc:title":"blood thiamin concentration"},{"@id":"https://cir.nii.ac.jp/all?q=urinary%20thiamin%20excretion","dc:title":"urinary thiamin excretion"},{"@id":"https://cir.nii.ac.jp/all?q=male%20adults","dc:title":"male adults"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001205733924352","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"二硫化型ビタミンB_1代謝の研究(I) : 食後および空腹時二硫化型B_1摂取後の尿中B_1排泄"},{"@language":"en","@value":"Studies on the Metabolism of Thiamine Disulfides (I) : Urinary Elimination of Thiamine after Oral Administration of Thiamine Disulfides directly after Meal or in Hunger"},{"@value":"二硫化型ビタミンB1代謝の研究-1・2-"},{"@language":"ja-Kana","@value":"2リュウカガタ ビタミン B1 タイシャ ノ ケンキュウ 1 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205760885632","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"健常成人におけるビタミンB_1、B_6およびB_<12>主薬製剤経口服用時の血中動態"},{"@language":"en","@value":"Pharmacokinetics and Bioavailability of Multivitamin Preparation of B_1, B_6, B_<12> and E in Human"},{"@language":"ja-Kana","@value":"ケンジョウ セイジン ニ オケル ビタミン B1 B6 オヨビ B12 シュヤ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205810971520","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"1. チオクロム螢光法による定量法(<研究実験講座>ビタミンB_1定量法"},{"@language":"en","@value":"1. DETERMINATION OF THIAMIN BY THE THIOCHROME REACTION(<Methods in Vitamenology Series>Assay Methods of Vitamin B_1)"},{"@value":"ビタミンB1定量法-1-チオクロム蛍光法による定量法"},{"@language":"ja-Kana","@value":"ビタミン B1 テイリョウホウ 1 チオクロム ケイコウホウ ニヨル テイリョ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205833529856","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"Thiamin Tetrahydrofurfuryl Disulfide含有内服用液剤投与後のヒト血液中ビタミンB_1濃度及び尿中排泄量"},{"@language":"en","@value":"Blood Level and Urinary Excretion of Vitamin B_1 after Oral Administration of a Liquid Preparation Containing Thiamin Tetrahydrofurfuryl Disulfide"},{"@language":"ja-Kana","@value":"Thiamin Tetrahydrofurfuryl Disulfide ガン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206292365696","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Bioavailability of Thiamine in Bread Made Using Yeast Treated with Rice Bran Extract."},{"@value":"米糠抽出液処理酵母を使用したパン中のビタミンＢ１の有効性"},{"@language":"ja-Kana","@value":"コメヌカ チュウシュツエキ ショリ コウボ オ シヨウ シタ パン チュウ ノ ビタミン B1 ノ ユウコウセイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680809935872","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"総合ビタミン剤を長期服用した場合の健康成人のビタミンB_1及びB_2の血中濃度・尿中排泄"},{"@language":"en","@value":"Changes in Blood Concentrations and Urinary Excretion of Thiamin and Riboflavin During Daily Oral Administration of Multivitamin Tablets to Healthy Adults for 44 Weeks."},{"@language":"ja-Kana","@value":"ソウゴウ ビタミンザイ オ チョウキ フクヨウシタ バアイ ノ ケンコウ セイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680810201984","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ビタミン製剤経口投与時のビタミンB_1及びB_2の血中濃度・尿中排泄"},{"@language":"en","@value":"Blood Levels and Urinary Excretion of Vitamin B_1 and Vitamin B_2 Following Oral Administration of Vitamin Preparations"},{"@language":"ja-Kana","@value":"ビタミン セイザイ ケイコウ トウヨジ ノ ビタミン B1 オヨビ B2 ノ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680810206976","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"薬物動態試験,血球移行性試験およびB_1復元試験よりみたビタミンB_1誘導体の評価"},{"@language":"en","@value":"Evaluation of Thiamin Derivatives : Human Bioavailability, Uptake by Human Blood Cells, and Conversion to Thiamin by Rat Liver Homogenate"},{"@language":"ja-Kana","@value":"ヤクブツ ドウタイ シケン ケッキュウ イコウセイ シケン オヨビ B1 フク"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680810716800","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"Thiamin Tetrahydrofurfuryl Disulfideまたはチアミン含有内服用液剤を健康成人男子が服用した時のビタミンB_1の薬物動態"},{"@language":"en","@value":"Changes in Blood Concentrations and Urinary Excretion of Vitamin B_1 following Single Oral Administration of Liquid Preparations Containing Thiamin Tetrahydrofurfuryl Disulfide or Thiamin to Healthy Male Adults."},{"@value":"Thiamin Tetrahydrofurfury1 Disulfideまたはチアミン含有内服用液剤を健康成人男子が服用した時のビタミンB1の薬物動態"},{"@language":"ja-Kana","@value":"Thiamin Tetrahydrofurfury1 Disulfide マタ"}]},{"@id":"https://cir.nii.ac.jp/crid/1520009408412359552","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"一人暮らし高齢者の栄養状態--とくにビタミンA,B1,およびCについて"},{"@language":"ja-Kana","@value":"ヒトリグラシ コウレイシャ ノ エイヨウ ジョウタイ トクニ ビタミン A B"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417124312520576","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571980074493519488","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572543026553376256","@type":"Article","relationType":["cites"]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2003947647"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I3605979"},{"@type":"CIA","@value":"110002848150"}]}