書誌事項
- タイトル別名
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- Effect of Gallic Acid Derivatives on Secretion of Th1 Cytokines and Th2 Cytokines from Anti CD3-Stimulated Spleen Cells.
- ヘルパー Tサイボウ サブタイプ トクイテキ サイトカイン ブンピ エ ノ ボッショクシサン ユウドウタイ ノ エイキョウ
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説明
As reported previously (Kosuge et al., Yakugaku Zasshi, 120, 408 (2000)), methyl gallate, a gallic acid derivative, which has been one of compounds isolated from extracts of Psidium geneus Myrtaceae, selectively suppresses Th2 cytokine secretion. In the present study, to examine more effective compounds than methyl gallate, the effects of various gallic acid derivatives on the secretion of helper T cell subtype specific cytokines from anti CD3-stimulated spleen cells were investigated. Ten μg/ml of methyl gallate and ethyl gallate remarkably suppressed the secretion of IL-4 and IL-5, Th2 cytokines, but did not suppress meaningfully the secretion of IFN-γ, a Th1 cytokine. On the other hand, the other gallic acid derivatives suppressed the secretion of both IL-4 and IFN-γ. Ten μg/ml of methyl gallate suppressed the secretion of IL-2, a Th1 cytokine, but the same concentration of ethyl gallate did not suppress it. In conclusion, it seemed that ethyl gallate was the most selective inhibitor for the secretion of Th2 cytokines among gallic acid derivatives used in this study.
収録刊行物
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- 薬学雑誌
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薬学雑誌 121 (6), 451-457, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681105163776
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- NII論文ID
- 110003648533
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- NII書誌ID
- AN00284903
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- COI
- 1:CAS:528:DC%2BD3MXkt1ygt7w%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 5784362
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- PubMed
- 11433779
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可