{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282681259527552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11250/chemotherapy1953.28.supplement4_377"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"2221331"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/2221331"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I2221331"}},{"identifier":{"@type":"NAID","@value":"130004071524"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1981189342"}}],"dc:title":[{"@language":"en","@value":"CLINICAL EVALUATION OF CINOXACIN IN COMPLICATED URINARY TRACT INFECTIONS"},{"@value":"複雑性尿路感染症に対するCinoxacinの臨床効果"},{"@language":"ja-Kana","@value":"フクザツセイ ニョウロ カンセンショウ ニ タイスル Cinoxacin ノ"}],"dcterms:alternative":[{"@language":"en","@value":"A COMPARATIVE STUDY WITH NALIDIXIC ACID BY A RANDOMIZED DOUBLE BLIND METHOD"},{"@value":"Nalidixic acidとの二重盲検比較試験"}],"description":[{"type":"abstract","notation":[{"@language":"en","@value":"The clinical efficacy, usefulness and safety of cinoxacin (CINX) in complicated urinary tract infections were evaluated by double blind comparison with nalidixic acid (NA). CINX and NA were administered 400mg b. i. d. and 1, 000mg t. i. d. for 5 days respectively.<BR>The results were summarized as follows;<BR>1. As to the overall clinical efficacy the rates of excellent, moderate and poor were 15%, 23% and 62% with CINX in 113 patients and 17%, 13% and 70% with NA in 111 patients, respectively without significant difference between the two groups.<BR>2. On evaluation of efficacy on bacteriuria, CINX showed significantly higher clearance rate than NA against <I>S. marcescens</I> and bacteria having MIC of over 800μg/ml.<BR>3. In the global judgement made by the attending physicians, CINX showed better tendency in the efficacy and usefulness than that of NA.<BR>4. Because both CINX and NA showed no antibacterial activity against <I>P. aeruginosa</I>, the same evaluations were made in the cases excluded <I>P. aeruginosa</I>. CINX showed significantly higher efficacy rate than NA on overall clinical efficacy in catheter indwelt patients.<BR>5. Incidence of adverse reaction was 2.1% and 6.0% in CINX and NA respectively. Deterioration on clinical findings was observed in one case in each group.<BR>From the above results, CINX would be a useful oral drug in the treatment of complicated urinary tract infections."},{"@value":"新合成経口化学療法薬Cinoxacin (以下CINXと略す) の複雑性尿路感染症に対する臨床効果, 安全性および有用性を検討するためNalidixic acid (以下NAと略す) を対照薬とした二重盲検比較試験を行なった。<BR>CINXは1回400mgを1日2回, NAは1回1,000mgを1日3回, それぞれ5日間連続投与し, UTI薬効評価基準 (第二版) に準じた委員会判定と主治医の判定, 有用性の判定を行なった。<BR>委員会判定の総合臨床効果では有効率で両群間に有意差は認められなかったが<I>Serratia marcescens</I>の消失率, 800μg/ml以上のMICの細菌の消失率はCINX群の方が有意に高かった。また単独感染群においてはCINX群の細菌尿消失率がNA群に比べ高い傾向にあった。<BR>主治医による判定では有効率においてCINX群の方がNA群に比べ高い傾向にあった。有用性は非常に満足から満足, まずまずまでの各頻度を加えるとCINX群の方がNA群より高い傾向にあった。<BR>また両薬の抗菌力を考慮して<I>Pseudomonas aeruginosa</I>感染例を除いた症例での検討も行なったが, いくつかの点においてCINX群の方がNA群に比し優れた値を示す結果を得た。<BR>自覚的副作用はCINX群145例中3例 (2.1%), NA群149例中9例 (6.0%) に認められ, 胃腸障害がほとんどであった。臨床検査値の検討では主治医が投薬と関係ありと認めたものは両群に1例ずつ認められた。<BR>以上の結果より, CINXは経口用薬としては複雑性尿路感染症にかなり有用であることが認められたが, 感染菌の確実な把握が必要であることも判明した。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410290697028640267","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742530"}],"foaf:name":[{"@language":"en","@value":"MOMOSE SHUNRO"},{"@language":"ja","@value":"百瀬 俊郎"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, Faculty of Medicine, Kyushu University"},{"@language":"ja","@value":"九州大学医学部泌尿器科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640270","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742537"}],"foaf:name":[{"@language":"en","@value":"KUMAZAWA JOICHI"},{"@language":"ja","@value":"熊沢 浄一"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, Faculty of Medicine, Kyushu University"},{"@language":"ja","@value":"九州大学医学部泌尿器科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640260","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742538"}],"foaf:name":[{"@language":"en","@value":"SAKAMOTO KIMITAKA"},{"@language":"ja","@value":"坂本 公孝"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, School of Medicine, Fukuoka University"},{"@language":"ja","@value":"福岡大学医学部泌尿器科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640262","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742539"}],"foaf:name":[{"@language":"en","@value":"OSHIMA KAZUHIRO"},{"@language":"ja","@value":"大島 一寛"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, School of Medicine, Fukuoka University"},{"@language":"ja","@value":"福岡大学医学部泌尿器科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640265","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742540"}],"foaf:name":[{"@language":"en","@value":"ETO KOSAKU"},{"@language":"ja","@value":"江藤 耕作"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"久留米大学医学部泌尿器科"},{"@language":"en","@value":"Department of Urology, School of Medicine, Kurume University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640269","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742541"}],"foaf:name":[{"@language":"en","@value":"SAKAI YUICHI"},{"@language":"ja","@value":"境 優一"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"久留米大学医学部泌尿器科"},{"@language":"en","@value":"Department of Urology, School of Medicine, Kurume University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640258","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742542"}],"foaf:name":[{"@language":"en","@value":"IKEGAMI KEIICHI"},{"@language":"ja","@value":"池上 奎一"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, Medical School, Kumamoto University"},{"@language":"ja","@value":"熊本大学医学部泌尿器科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640264","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742543"}],"foaf:name":[{"@language":"en","@value":"NOMURA YOSHIO"},{"@language":"ja","@value":"野村 芳雄"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, Medical School, Kumamoto University"},{"@language":"ja","@value":"熊本大学医学部泌尿器科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640268","@type":"Researcher","foaf:name":[{"@language":"en","@value":"KONDO ATSUSHI"},{"@language":"ja","@value":"近藤 厚"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, School of Medicine, Nagasaki University"},{"@language":"ja","@value":"長崎大学医学部泌尿器科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640261","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742531"}],"foaf:name":[{"@language":"en","@value":"SAITO HISASHI"},{"@language":"ja","@value":"斎藤 泰"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"長崎大学医学部泌尿器科"},{"@language":"en","@value":"Department of Urology, School of Medicine, Nagasaki University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640257","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742532"}],"foaf:name":[{"@language":"en","@value":"ISHISAWA NOBUYUKI"},{"@language":"ja","@value":"石沢 靖之"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, Miyazaki Medical College"},{"@language":"ja","@value":"宮崎医科大学泌尿器科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640263","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742533"}],"foaf:name":[{"@language":"en","@value":"SENO KOHEI"},{"@language":"ja","@value":"妹尾 康平"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎医科大学泌尿器科"},{"@language":"en","@value":"Department of Urology, Miyazaki Medical College"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640256","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742534"}],"foaf:name":[{"@language":"en","@value":"OKAMOTO KENICHIRO"},{"@language":"ja","@value":"岡元 健一郎"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"鹿児島大学医学部泌尿器科"},{"@language":"en","@value":"Department of Urology, Faculty of Medicine, Kagoshima University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640259","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255742535"}],"foaf:name":[{"@language":"en","@value":"OHI YOSHITADA"},{"@language":"ja","@value":"大井 好忠"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, Faculty of Medicine, Kagoshima University"},{"@language":"ja","@value":"鹿児島大学医学部泌尿器科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697028640266","@type":"Researcher","foaf:name":[{"@language":"en","@value":"OHSAWA AKIRA"},{"@language":"ja","@value":"大沢 炯"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"琉球大学保健学部泌尿器科"},{"@language":"en","@value":"Department of Urology, Faculty of Health Science, Ryukyu University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00093165"},{"@type":"EISSN","@value":"18845894"},{"@type":"NDL_BIB_ID","@value":"000000000101"},{"@type":"ISSN","@value":"00093165"},{"@type":"LISSN","@value":"00093165"},{"@type":"NCID","@value":"AN00186653"}],"prism:publicationName":[{"@language":"en","@value":"CHEMOTHERAPY"},{"@language":"ja","@value":"ＣＨＥＭＯＴＨＥＲＡＰＹ"},{"@language":"en","@value":"Chemother."},{"@language":"ja","@value":"ＣＨＥＭＯＴＨＥＲＡＰＹ"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Chemotherapy"},{"@language":"ja","@value":"公益社団法人 日本化学療法学会"}],"prism:publicationDate":"1980","prism:volume":"28","prism:number":"Supplement4","prism:startingPage":"377","prism:endingPage":"399"},"url":[{"@id":"http://id.ndl.go.jp/bib/2221331"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I2221331"},{"@id":"https://search.jamas.or.jp/link/ui/1981189342"}],"availableAt":"1980","dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0037898737"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I2221331"},{"@type":"CIA","@value":"130004071524"}]}