{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282681269320192.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4327/jsnfs.50.287"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"4286691"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/4286691"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I4286691"}},{"identifier":{"@type":"NAID","@value":"10009283560"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1998043982"}}],"dc:title":[{"@language":"en","@value":"Digestion, Absorption and Intestinal Residue of Various Gluconic Acids in Rats."},{"@value":"各種グルコン酸のラットにおける消化吸収性と消化管内残存量"},{"@language":"ja-Kana","@value":"カクシュ グルコンサン ノ ラット ニ オケル ショウカ キュウシュウセイ ト"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Glucanic acids exist in the form of free acid (GA), anhydride (glucono-δ-lactone: GDL), gluconate salts such as sodium salt (GNA), potassium salt (GK), or calcium salt (GCA). Digestions of various gluconic acids were measured <I>in vitro</I> using human saliva, artificial gastric juice, porcine pancreatin and rat intestinal mucosa. Gluconic acid was stable in these digestive juices, regardless of its form. In an absorption test in situ using ligated loops of rat small intestine, residual gluconic acid in the loops was measured at 30min after injection at a dose of 50mg/kg. While 100% of the gluconate salts remained in the loop, the residual rates of GDL and GA were 45% and 86% respectively. Changes in plasma gluconic acid levels after oral administration of various gluconic acids at a dose of 500mg/kg were investigated in rats. Plasma contents 30min after for administratian of glucanates were only 1.7-2.2μg/ml, whereas those for GDL and GA were 91μg/ ml and 38μg/ml, respectively. In germ-free rats, the residual rates in the digestive tract at 8h after oral administration of GDL, GA and GCA at a dose of 50mg/kg were 25%, 68% and 90%, respectively."},{"@value":"グルコン酸は遊離の酸の状態 (GA) と無水物であるラクトン体の状態 (GDL) およびナトリウム塩 (GNA), カリウム塩 (GK), カルシウム塩 (GCA) 等の塩を形成した状態が存在する。これらの形態におけるグルコン酸類のラットでの消化管吸収と残存について比較した。<BR><I>in vitro</I>におけるヒト唾液, 人工胃液, ブタ膵液パンクレアチンおよびラット小腸粘膜酵素の各種消化液中で, グルコン酸はその形態にかかわらず常に安定であった。<BR>in situでのラット小腸ループでの吸収性試験 (50mg/kg注入) で, 30分後にグルコン酸の塩類は腸管内に100%残存していたのに対して, GDLは45%, GAは86%になり, 形態によって差が見られた。<BR>各種グルコン酸をラットに500mg/kg経口投与し, 30分後の血漿中濃度はグルコン酸塩類はわずか1.7～2.2μg/mlであるのに対してGDLは91μg/ml, GAは38μg/mlとなり, 吸収量に大きな差があった。<BR>各種グルコン酸50mg/kg経口投与後の尿中排泄率は, グルコン酸塩類で0.8～1.5%, GDLで19%, GAで5.5%となった。これに対して, 各種グルコン酸10mg/kg静脈注射後の尿中に排泄される量を測定すると, GNAは87%が尿中に回収されたのに対してGDLは36%, GAは58%の回収率であった。このことから, GDLとGAは経口投与後に血中に吸収されても代謝を受けるため, 尿中には一部しか排泄されないことが示唆された。<BR>無菌ラットを使用して50mg/kg経口投与8時間後の消化管内に残存する量を直接測定すると, GDLは25%, GAは68%, GCAは90%の残存率であった。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679328020481","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000835694"},{"@type":"NRID","@value":"9000254083451"}],"foaf:name":[{"@language":"en","@value":"ASANO Toshihiko"},{"@language":"ja","@value":"浅野 敏彦"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Chemical Products Research Laboratories, Fujisawa Pharmaceutical Co., Ltd."},{"@language":"ja","@value":"藤沢薬品工業株式会社特薬研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679328020482","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000835695"},{"@type":"NRID","@value":"9000254083452"}],"foaf:name":[{"@language":"en","@value":"YUASA Kazuhiro"},{"@language":"ja","@value":"湯浅 一博"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Chemical Products Research Laboratories, Fujisawa Pharmaceutical Co., Ltd."},{"@language":"ja","@value":"藤沢薬品工業株式会社特薬研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282681269320194","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000835696"}],"foaf:name":[{"@language":"en","@value":"YOSHIMURA Yasumi"},{"@language":"ja","@value":"吉村 康美"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Chemical Products Research Laboratories, Fujisawa Pharmaceutical Co., Ltd."},{"@language":"ja","@value":"藤沢薬品工業株式会社特薬研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679328020480","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000389559405"},{"@type":"NRID","@value":"9000254083455"}],"foaf:name":[{"@language":"en","@value":"TAKENAWA Seishi"},{"@language":"ja","@value":"竹縄 誠之"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"藤沢薬品工業株式会社特薬研究所"},{"@language":"en","@value":"Chemical Products Research Laboratories, Fujisawa Pharmaceutical Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282681269320193","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000347421999"}],"foaf:name":[{"@language":"en","@value":"FUKUBA Hiroyasu"},{"@language":"ja","@value":"福場 博保"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Graduate School of Practical Sciences, Showa Women's University"},{"@language":"ja","@value":"昭和女子大学生活機構研究科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02873516"},{"@type":"LISSN","@value":"02873516"},{"@type":"EISSN","@value":"18832849"},{"@type":"CODEN","@value":"NESGDC"},{"@type":"NDL_BIB_ID","@value":"000000037891"},{"@type":"ISSN","@value":"02873516"},{"@type":"NCID","@value":"AN00311992"}],"prism:publicationName":[{"@language":"en","@value":"Nippon Eiyo Shokuryo Gakkaishi"},{"@language":"ja","@value":"日本栄養・食糧学会誌"},{"@language":"en","@value":"J Jpn Soc Nutr Food Sci"},{"@language":"en","@value":"Journal of Japanese Society of Nutrition and Food Science"},{"@language":"en","@value":"Nippon Eiyo Shokuryo Gakkaishi"},{"@language":"ja","@value":"日本栄養・食糧学会誌"},{"@language":"en","@value":"JJSNFS"},{"@language":"en","@value":"Nippon Eiyo Shokuryo Gakkaishi"},{"@language":"ja","@value":"栄食誌"}],"dc:publisher":[{"@language":"en","@value":"Japan Society of Nutrition and Food Science"},{"@language":"ja","@value":"公益社団法人 日本栄養・食糧学会"}],"prism:publicationDate":"1997","prism:volume":"50","prism:number":"4","prism:startingPage":"287","prism:endingPage":"294"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/4286691"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I4286691"},{"@id":"https://search.jamas.or.jp/link/ui/1998043982"}],"availableAt":"1997","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=gluconic%20acid","dc:title":"gluconic acid"},{"@id":"https://cir.nii.ac.jp/all?q=gluconate","dc:title":"gluconate"},{"@id":"https://cir.nii.ac.jp/all?q=digestion","dc:title":"digestion"},{"@id":"https://cir.nii.ac.jp/all?q=absorption","dc:title":"absorption"},{"@id":"https://cir.nii.ac.jp/all?q=intestinal%20residue","dc:title":"intestinal residue"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360567189395715712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Determination of Dehydrogenase Activities Involved in D-Glucose Oxidation in Gluconobacter and Acetobacter Strains"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369873987456","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Mutarotase effect on colorimetric determination of blood glucose with β-D-glucose oxidase"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749820129536","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570009749820130560","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570572699773549952","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571135649726968576","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571135649726973312","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571417124703681280","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571980074058973056","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571980074657099776","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571980074657101824","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572261549633811840","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572543024610527744","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573105974563948928","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573387449380174080","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573668924433052544","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573668924517369088","@type":"Article","relationType":["cites"]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0008412082"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I4286691"},{"@type":"CROSSREF","@value":"10.4327/jsnfs.50.287"},{"@type":"CIA","@value":"10009283560"},{"@type":"CROSSREF","@value":"10.3389/fmicb.2016.01358_references_DOI_QixaKFRPVKi9EBtjGFV8uhn1b6R"}]}