書誌事項
- タイトル別名
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- N-Linked Oligosaccharide Processing Enzymes as Molecular Targets for Drug Discovery
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説明
N-Linked oligosaccharide processing enzymes are key enzymes in the biosynthesis of N-linked oligosaccharides. These enzymes are a molecular target for inhibition by anti-viral agents that interfere with the formation of essential glycoproteins required in viral assembly, secretion and infectivity. We think that the molecular recognition of three kinds of glucosidases (family 13 and family 31 α-glucosidases and endoplasmic reticulum glucosidases) are different. Therefore, glycon and aglycon specificity profiling of glucosidases was an important approach for the research of glucosidase inhibitors. We carried out the profiling of glucosidases using small molecules as a probe. Moreover, we designed and synthesized three types of glucosidase inhibitors. These compounds were evaluated with regard to their ability to inhibit glucosidases in vitro, and were also tested in a cell culture system. We found some compounds having glucosidase inhibitory activity and anti-viral activity.
収録刊行物
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- Journal of Applied Glycoscience
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Journal of Applied Glycoscience 53 (2), 149-154, 2006
日本応用糖質科学会
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詳細情報 詳細情報について
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- CRID
- 1390282681270745344
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- NII論文ID
- 10016802897
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- NII書誌ID
- AN10453916
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- COI
- 1:CAS:528:DC%2BD28Xmt12itb4%3D
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- ISSN
- 18807291
- 13447882
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- NDL書誌ID
- 7968762
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可