Assays for Thyroid-stimulating Antibodies and Thyrotropin-binding Inhibitory Immunoglobulins in Children with Graves' Disease
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- SHIBAYAMA Keiko
- Department of Pediatrics, Kitasato University School of Medicine
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- OHYAMA Yoshihide
- Department of Pediatrics, Kitasato University School of Medicine
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- YOKOTA Yukifumi
- Department of Pediatrics, Kitasato University School of Medicine
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- OHTSU Shigeyuki
- Department of Pediatrics, Kitasato University School of Medicine
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- TAKUBO Noriyuki
- Department of Pediatrics, Kitasato University School of Medicine
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- MATSUURA Nobuo
- Department of Pediatrics, Kitasato University School of Medicine
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Studies on thyrotropin receptor autoantibodies (TRAb) by measurement of both thyroid-stimulating antibodies (TSAb) and thyrotropin-binding inhibitory immunoglobulins (TBII) in serum from children with Graves' disease are limited in number of studies. The aim of this study was to investigate the levels of serum TSAb and TBII in children with Graves' disease, and to evaluate the clinical significance of these antibodies. We measured the serum TSAb and TBII at diagnosis and during management in 65 children with Graves' disease. Patients were divided into four groups according to their metabolic state: those with untreated active Graves' disease, those receiving treatment with antithyroid drugs, those in remission, and those in relapse. At diagnosis, both TSAb and TBII assays had high sensitivities and high specificities. In follow-up, the levels of both TSAb and TBII paralleled the course of the disease. There was a strong positive correlation between TSAb and TBII. TBII levels were significantly higher in the patients with ophthalmopathy than those without ophthalmopathy in untreated Graves' children. It was concluded that TSAb and TBII measurements are valuable in the diagnosis and management of children with Graves' disease.<br>
収録刊行物
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- Endocrine Journal
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Endocrine Journal 52 (5), 505-510, 2005
一般社団法人 日本内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390282681274514176
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- NII論文ID
- 130004443158
- 10016781993
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- NII書誌ID
- AA10901436
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- ISSN
- 13484540
- 09188959
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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