{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282681294436992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11261/iryo1946.30.743"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"1722688"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/1722688"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I1722688"}},{"identifier":{"@type":"NAID","@value":"130004106653"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1977001674"}}],"dc:title":[{"@language":"en","@value":"Immunosuppressive Therapy in Rheumatic Diseases"},{"@value":"リウマチ性疾患の免疫抑制療法"},{"@language":"ja-Kana","@value":"リウマチセイ シッカン ノ メンエキ ヨクセイ リョウホウ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"There is no curative treatment of rheumatic diseases because of lack of knowledge of the cause and pathogenesis about them. Many evidences for an immunological disturbance in rheumatic diseases are noted and the hypothesis that autoimmunity may play a fundamental role in their pathogenesis generally believed. Therefore the immunosuppressive agents have been used in their treatment.<br>Immunosuppressive therapy in rheumatic diseases were discussed and literatures are reviewed and guidelines for use of the drugs were introduced here. Reports indicating efficacy of the immunosuppressive therapy in rheumatic diseases have been increasing recently. But efficacy of the therapy is not always enough and also it has not yet an established role in management of rheumatic diseases. Side effects are frequent and sometimes serious, so that patient should be selected cautiously and meticulous follow-up care should be performed during the therapy.<br>Although true curative treatment would not be possible untill etiology or pathogenesis of rheumatic diseases have been established, the immunosuppressive therapy is expected as one of the hopeful treatment. Further therapeutic studies are needed to place it in the management of rheumatic diseases."},{"@value":"リウマチ性疾患の原因は不明なので, 根本的治療法はまだ確立されていない. リウマチ性疾患には免疫異常の存在を示唆する事実が多く見出され, 一般に自己免疫が病因上の主要の役割を演じているものと考えられている. この意味から免疫抑制剤が試用されだしたことは当然ともいえるわけであろう.<br>ここではリウマチ性疾患の免疫抑制療法について文献的に考察し, 使用の指標について述べた. 近年その効果を示す報告がふえているが, 必ずしも十分とはいえず, また治療上の役割についても確立されたものではない. 副作用の頻度は高く, 時に重大なものもある, それゆえ, 免疫抑制剤を使用するさいには, 慎重に患者を選択し使用経過中には細心の注意を払わねばならない.<br>恐らくリウマチ性疾患の病因が解明されない限り, 真の治療法は確立されないだろうが, 免疫抑制療法は希望を抱かせる療法の一つである. 本療法をリウマチ性疾患の治療上に位置づけるためにもさらに今後の研究が必要である."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410572171940478592","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255849904"}],"foaf:name":[{"@language":"en","@value":"YOSHIZAWA Hisayoshi"},{"@language":"ja","@value":"吉沢 久嘉"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Sagamihara National Hospital"},{"@language":"ja","@value":"国立相模原病院内科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00211699"},{"@type":"EISSN","@value":"18848729"},{"@type":"NDL_BIB_ID","@value":"000000001666"},{"@type":"ISSN","@value":"00211699"},{"@type":"LISSN","@value":"00211699"},{"@type":"NCID","@value":"AN00017113"}],"prism:publicationName":[{"@language":"en","@value":"Japanese Journal of National Medical Services"},{"@language":"ja","@value":"医療"},{"@language":"en","@value":"Japanese Journal of National Medical Services"},{"@language":"ja","@value":"医療"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of National Medical Services"},{"@language":"ja","@value":"一般社団法人 国立医療学会"}],"prism:publicationDate":"1976","prism:volume":"30","prism:number":"8","prism:startingPage":"743","prism:endingPage":"749"},"url":[{"@id":"http://id.ndl.go.jp/bib/1722688"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I1722688"},{"@id":"https://search.jamas.or.jp/link/ui/1977001674"}],"availableAt":"1976","dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0038531610"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I1722688"},{"@type":"CIA","@value":"130004106653"}]}