Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

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  • SAKAI Tohru
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • TAKI Tomoyo
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • NAKAMOTO Akiko
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • SHUTO Emi
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • TSUTSUMI Rie
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • TOSHIMITSU Takayuki
    Department of Lactic Acid Bacteria Research, Institute of Food Functionality Research, Division of Research and Development, Meiji Corporation
  • MAKINO Seiya
    Department of Lactic Acid Bacteria Research, Institute of Food Functionality Research, Division of Research and Development, Meiji Corporation
  • IKEGAMI Shuuji
    Department of Lactic Acid Bacteria Research, Institute of Food Functionality Research, Division of Research and Development, Meiji Corporation

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  • <i>Lactobacillus plantarum</i> OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

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The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 109 cfu heat-killed L. plantarum OLL2712 for 12 wk showed significant reduction of blood glucose levels in response to insulin. Furthermore, mRNA expression of interleukin-1β in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice. These results indicate that L. plantarum OLL2712 regulates glucose metabolism.

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