{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282681301635840.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3177/jnsv.49.172"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BD3sXlsVOgtb0%3D"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"6589732"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/6589732"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I6589732"}},{"identifier":{"@type":"PMID","@value":"12953795"}},{"identifier":{"@type":"NAID","@value":"130001377333"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2004133328"}}],"dc:title":[{"@language":"en","@value":"IgE Responses in Mice Fed Moderate Protein Deficient and High Protein Diets"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"While severe protein energy malnutrition (PEM) has been known to depress several immune functions, allergies are suppressed by decreasing IgE and impairing vascular permeability and mast cell functions. To address the effect of moderate protein malnutrition without growth arrest and protein hypernutrition on type I allergy, we examined the effect of various levels of protein nutrition on allergy at humoral immunity and the regulation of Th cell function levels. Mice fed 100g/kg (moderate protein malnutrition; MPM), 200g/kg (normal protein nutrition; PN) and 400g/kg (protein hypernutrition; PH) protein diets were intraperitoneally sensitized to ovalbumin (OVA) in aluminum hydroxide. Higher elevations of OVA-specific IgE and total IgE in the serum were observed in the PH group as compared to the PN group. However, OVA-specific IgE in the MPM group was not significantly different from that in the PN group, although the former appeared higher than the latter. While CD3, CD4, CD8 and B220 expressions in the splenic lymphocytes were decreased in the MPM group, B220 expressions were increased in the PH group. Splenic lymphocyte proliferative responses to OVA were augmented in the PH group and depressed in the MPM group. IFN-yproduction from splenic lymphocytes was significantly decreased; however, IL-4 production was not affected significantly in the MPM group, and increased in the PH group. These findings suggest that immune functions to specific antigens in the MPM state are depressed at the cytokine level but not in terms of IgE responses. They also suggest that immune functions become Th2-predominant in the PH state, resulting in an increased risk of type I allergy."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658407753857","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60196037"},{"@type":"NRID","@value":"1000060196037"},{"@type":"NRID","@value":"9000363175580"},{"@type":"NRID","@value":"9000398022735"},{"@type":"NRID","@value":"9000399805956"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0098985"}],"foaf:name":[{"@language":"en","@value":"SAKAI Kentaro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Environmental Science, Faculty of Human Development, University of Hiroshima Jyogakuin"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206321378821","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004482291"},{"@type":"NRID","@value":"9000390913340"},{"@type":"NRID","@value":"9000005564660"},{"@type":"NRID","@value":"9000350535146"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/338086"}],"foaf:name":[{"@language":"en","@value":"YOSHINO Kenji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Nutrition, University of Tokushima School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801184026368","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20433774"},{"@type":"NRID","@value":"1000020433774"},{"@type":"NRID","@value":"9000004643458"},{"@type":"NRID","@value":"9000256562507"},{"@type":"NRID","@value":"9000018736864"},{"@type":"NRID","@value":"9000257715126"},{"@type":"NRID","@value":"9000002246903"},{"@type":"NRID","@value":"9000002833015"}],"foaf:name":[{"@language":"en","@value":"OKADA Hiroko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Nutrition, University of Tokushima School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276167401344","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80457762"},{"@type":"NRID","@value":"1000080457762"},{"@type":"KAKEN_RESEARCHERS","@value":"40274196"},{"@type":"NRID","@value":"1000040274196"},{"@type":"CINII_AUTHOR_ID","@value":"DA18635217"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA18635217#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA18635217"},{"@type":"NRID","@value":"9000017046694"},{"@type":"NRID","@value":"9000002469766"},{"@type":"NRID","@value":"9000347318952"},{"@type":"NRID","@value":"9000413572805"},{"@type":"NRID","@value":"9000002946718"},{"@type":"NRID","@value":"9000402392509"},{"@type":"NRID","@value":"9000263064835"},{"@type":"NRID","@value":"9000242353667"},{"@type":"NRID","@value":"9000402810987"},{"@type":"NRID","@value":"9000257899755"},{"@type":"NRID","@value":"9000291602420"},{"@type":"NRID","@value":"9000412546919"},{"@type":"NRID","@value":"9000399836786"},{"@type":"NRID","@value":"9000408918567"},{"@type":"NRID","@value":"9000283099253"},{"@type":"NRID","@value":"9000020110819"},{"@type":"NRID","@value":"9000386284395"},{"@type":"NRID","@value":"9000347253485"},{"@type":"NRID","@value":"9000283280727"},{"@type":"NRID","@value":"9000016883443"},{"@type":"NRID","@value":"9000404127649"},{"@type":"NRID","@value":"9000370764911"},{"@type":"NRID","@value":"9000412158419"},{"@type":"NRID","@value":"9000257900796"},{"@type":"NRID","@value":"9000241821692"},{"@type":"NRID","@value":"9000397934861"},{"@type":"NRID","@value":"9000356627823"},{"@type":"NRID","@value":"9000283280468"},{"@type":"NRID","@value":"9000283280807"},{"@type":"NRID","@value":"9000283281686"},{"@type":"NRID","@value":"9000334424766"},{"@type":"NRID","@value":"9000283282194"},{"@type":"NRID","@value":"9000018603225"},{"@type":"NRID","@value":"9000016883259"},{"@type":"NRID","@value":"9000016883253"},{"@type":"NRID","@value":"9000258085261"},{"@type":"NRID","@value":"9000010165949"},{"@type":"NRID","@value":"9000257900342"},{"@type":"NRID","@value":"9000241653512"},{"@type":"NRID","@value":"9000411476445"},{"@type":"NRID","@value":"9000413558887"},{"@type":"NRID","@value":"9000018736865"},{"@type":"NRID","@value":"9000292880163"},{"@type":"NRID","@value":"9000253019266"},{"@type":"NRID","@value":"9000253285049"},{"@type":"NRID","@value":"9000414223946"},{"@type":"NRID","@value":"9000343337494"},{"@type":"NRID","@value":"9000380126094"},{"@type":"NRID","@value":"9000242882730"},{"@type":"NRID","@value":"9000305637505"},{"@type":"NRID","@value":"9000403155102"},{"@type":"NRID","@value":"9000283280767"},{"@type":"NRID","@value":"9000007490628"},{"@type":"NRID","@value":"9000253286288"},{"@type":"NRID","@value":"9000410657836"},{"@type":"NRID","@value":"9000257901026"},{"@type":"NRID","@value":"9000020261986"},{"@type":"NRID","@value":"9000240066600"},{"@type":"NRID","@value":"9000257906853"},{"@type":"NRID","@value":"9000414861494"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0021744"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0184057"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/sakai_toru"}],"foaf:name":[{"@language":"en","@value":"SAKAI Tohru"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Nutrition, University of Tokushima School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205432964995","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004303303"}],"foaf:name":[{"@language":"en","@value":"YAMAMOTO Shigeru"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Nutrition, University of Tokushima School of Medicine"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03014800"},{"@type":"LISSN","@value":"03014800"},{"@type":"EISSN","@value":"18817742"},{"@type":"CODEN","@value":"JNSVA5"},{"@type":"NDL_BIB_ID","@value":"000000119513"},{"@type":"ISSN","@value":"03014800"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/03014800"},{"@type":"NCID","@value":"AA00703822"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Nutritional Science and Vitaminology"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ"},{"@language":"en","@value":"J Nutr Sci Vitaminol"},{"@language":"en","@value":"JNSV"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ"},{"@language":"en","@value":"Journal of Nutritional Science and Vitaminology, J Nutr Sci Vitaminol"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ，　Ｊ　Ｎｕｔｒ　Ｓｃｉ　Ｖｉｔａｍｉｎｏｌ"},{"@language":"en","@value":"Journal of Nutritional Science and Vitaminology"}],"dc:publisher":[{"@language":"en","@value":"Center for Academic Publications Japan"},{"@language":"ja","@value":"一般財団法人 学会誌刊行センター"}],"prism:publicationDate":"2003","prism:volume":"49","prism:number":"3","prism:startingPage":"172","prism:endingPage":"178"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/6589732"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I6589732"},{"@id":"https://search.jamas.or.jp/link/ui/2004133328"}],"availableAt":"2003","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Protein%20hypernutrition","dc:title":"Protein hypernutrition"},{"@id":"https://cir.nii.ac.jp/all?q=moderate%20protein%20malnutrition","dc:title":"moderate protein malnutrition"},{"@id":"https://cir.nii.ac.jp/all?q=IgE","dc:title":"IgE"},{"@id":"https://cir.nii.ac.jp/all?q=IL-4","dc:title":"IL-4"},{"@id":"https://cir.nii.ac.jp/all?q=ovalbumin","dc:title":"ovalbumin"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143741590272","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Polyunsaturated fatty acids in maternal diet, breast milk, and serum lipid fatty acids of infants in relation to atopy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094565302912","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"The Effect of Moderate Protein Malnutrition on Murine T Cell Cytokine Production"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569312512768","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043723711104","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Functional diversity of helper T lymphocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519060343168","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"The murine IgG<sub>1</sub>/IgE class switch program"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993629278848","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Prostaglandin E<sub>2</sub> as a selective stimulator of antigen‐specific IgE response in murine lymphocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368637395456","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Diet, serum fatty acids, and atopic diseases in childhood"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371146383488","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844030951680","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844146534016","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release."}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793708220800","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Dietary habits among patients with atopic dermatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270006002432","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270055348096","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Regulation of IgG1 and IgE Synthesis by Interleukin 4 in Mouse B Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206325454080","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Modulation of Oral Tolerance to Ovalbumin by Dietary Protein in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225184631296","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Regulation of antibody isotype secretion by subsets of antigen specific helper T cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225184634880","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225184636032","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Alveolar macrophage function in rats with severe protein caloric malnutrition. Arachidonic acid metabolism, cytokine release, and antimicrobial activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175138053376","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prostaglandin E_2 is raised in kwashiorkor"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175138057344","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prostaglandin E_2 promotes B lymphocyte Ig isotype switching to IgE"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650114764032","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Characteristics of anaphylaxis in fasting rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650114765184","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of dietary restriction on spontaneous dermatitis in NC/Nga mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650114767616","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prostaglandin E_2 and IL-4 provide naive CD4+ T cells with distinct inhibitory signals for the priming of IFN-gamma production"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125091475328","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Protein malnutrition : effect on rat peritoneal mast cell number, histamine content, and IgE receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125091476480","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Anaphylactic reaction in experimental malnutrition"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075044898944","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Decrease in serum IgE associated with limited restriction in energy intake to treat toddler's diarrhea"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550021608064","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Splenocyte Glutathione and CD3-mediated cell proliferation are reduced in mice fed a protein-deficient diet"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550951122560","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Malnutrition and experimental lung allergy"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024998321408","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449928453632","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Why is allergy increasing?-Environmental factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924150589696","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Two types of murine helper T cell clone : I. Definition according to profiles of lymphokine activities and secreted proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924905160192","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Why does the prevalence of allergy increase more in industrialized than in developing countries?"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924905161344","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of low protein diet on IgE antibody responses in BALB/c mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924905162752","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fc (IgG) receptors on rat leukemia cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668926180875392","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Suppressed T helper 2 immunity and prolonged survival of nematode parasite in protein malnourished mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874858580736","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Sendai virus infection of mice with protein malnutrition"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874858581760","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Altered macrophage intracellular signaling induced by protein-calorie malnutrition"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231876142267648","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Influence of omega-3 and omega-6 fatty acid sources on prostaglandin levels in mice"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0023028026"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I6589732"},{"@type":"CROSSREF","@value":"10.3177/jnsv.49.172"},{"@type":"CIA","@value":"130001377333"},{"@type":"OPENAIRE","@value":"doi_dedup___::54627386886bfcba258f6acdff35b3cf"},{"@type":"CROSSREF","@value":"10.3177/jnsv.52.113_references_DOI_9BNyy1dqbgzSP716mU3C4HkVblD"}]}