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The frictional characteristics of pig shoulder joints were confirmed to depend on the viscosity of lubricants only in the physiologically low-load condition and immediately after the loading. A detergent (polyoxyethylene p-t-octylphenyl ether) was successfully used to remove adsorbed films from the articular surfaces. The friction coefficient of natural joints was significantly increased in mixed lubrication mode with a saline solution of sodium hyaluronate (0.2 g/dl) by surface treatment with the detergent. The addition of liposomes of Lα-DPPC or γ-globulin significantly improved the boundary lubricating ability of the articular surfaces treated with the detergent, depending on the quantity of the additives. It appears that the liposomes of Lα-DPPC and γ-globulin can form protective films on the articular surfaces in severe frictional 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