{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282681338752000.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1265/jjh.70.220"}},{"identifier":{"@type":"PMID","@value":"26411940"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"026796556"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/026796556"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I026796556"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jjh/70/3/70_220/_pdf"}},{"identifier":{"@type":"NAID","@value":"130005098975"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2016051592"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"ja","@value":"大気中微小粒子状物質（PM2.5）から生じる酸化ストレスと脳神経障害：第2部"},{"@language":"en","@value":"Oxidative Stress Derived from Airborne Fine and Ultrafine Particles and the Effects on Brain-Nervous System: Part 2"},{"@language":"ja-Kana","@value":"タイキ チュウ ビショウリュウシジョウ ブッシツ(PM2.5)カラ ショウジル サンカ ストレス ト ノウ シンケイ ショウガイ(ダイ2ブ)"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Traffic-related air pollution is a major contributor to urban air pollution. Diesel exhaust (DE) is its most important component of near-road and urban air pollutions and is commonly used as a surrogate model of air pollution in health effects studies. In particular, diesel exhaust particles (DEPs) and nanoparticles in DEPs are the components considered hazardous for health. It is widely known that exposure to DEPs is associated with mortality caused by respiratory and cardiovascular diseases. Recently, evidence has been accumulating showing that DEPs and nanoparticles may cause neurodegenerative disorders. Here, we introduce evidence suggesting their association with these disorders. The chemical components and the translocation of DEPs and nanoparticles to the brain are described in part 1. In part 2, we introduce the mechanism of development of neurodegenerative diseases such as stroke, Alzheimer’s disease, and Parkinson’s disease via oxidative stress and inflammatory events. Furthermore, there are many lines of epidemiological evidence showing that the particulates impair cognitive function and ability of memory through oxidative and inflammatory events in the brain. These lines of evidences are supported by many animal experiments on neurological disorders."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658623587587","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80124345"},{"@type":"NRID","@value":"1000080124345"},{"@type":"NRID","@value":"9000003768017"},{"@type":"NRID","@value":"9000381486834"},{"@type":"NRID","@value":"9000254791247"},{"@type":"NRID","@value":"9000252911105"},{"@type":"NRID","@value":"9000253556032"},{"@type":"NRID","@value":"9000016968966"},{"@type":"NRID","@value":"9000370242016"},{"@type":"NRID","@value":"9000003007202"},{"@type":"NRID","@value":"9000381487076"},{"@type":"NRID","@value":"9000391798731"},{"@type":"NRID","@value":"9000254597208"},{"@type":"NRID","@value":"9000381486699"},{"@type":"NRID","@value":"9000252911570"},{"@type":"NRID","@value":"9000008851770"},{"@type":"NRID","@value":"9000008054634"},{"@type":"NRID","@value":"9000254688005"},{"@type":"NRID","@value":"9000021871619"},{"@type":"NRID","@value":"9000392873776"},{"@type":"NRID","@value":"9000341534286"},{"@type":"NRID","@value":"9000003101402"},{"@type":"NRID","@value":"9000241512130"},{"@type":"NRID","@value":"9000331438918"},{"@type":"NRID","@value":"9000391639573"},{"@type":"NRID","@value":"9000305636745"},{"@type":"NRID","@value":"9000403976633"},{"@type":"NRID","@value":"9000009382117"},{"@type":"NRID","@value":"9000253193335"},{"@type":"NRID","@value":"9000278471213"},{"@type":"NRID","@value":"9000381485909"},{"@type":"NRID","@value":"9000381486235"},{"@type":"NRID","@value":"9000381485936"},{"@type":"NRID","@value":"9000253600543"},{"@type":"NRID","@value":"9000254791205"},{"@type":"NRID","@value":"9000254790299"},{"@type":"NRID","@value":"9000254597385"},{"@type":"NRID","@value":"9000256126012"},{"@type":"NRID","@value":"9000391803801"},{"@type":"NRID","@value":"9000007649959"},{"@type":"NRID","@value":"9000254671874"},{"@type":"NRID","@value":"9000020464671"},{"@type":"NRID","@value":"9000254301468"},{"@type":"NRID","@value":"9000255915408"},{"@type":"NRID","@value":"9000241782396"},{"@type":"NRID","@value":"9000254790874"},{"@type":"NRID","@value":"9000381486246"},{"@type":"NRID","@value":"9000391798604"},{"@type":"NRID","@value":"9000291602495"},{"@type":"NRID","@value":"9000254451147"},{"@type":"NRID","@value":"9000256125997"},{"@type":"NRID","@value":"9000024817001"},{"@type":"NRID","@value":"9000381486274"},{"@type":"NRID","@value":"9000253631888"},{"@type":"NRID","@value":"9000381487088"},{"@type":"NRID","@value":"9000381487399"},{"@type":"NRID","@value":"9000391797131"},{"@type":"NRID","@value":"9000254791026"}],"foaf:name":[{"@language":"ja","@value":"嵯峨井 勝"},{"@language":"en","@value":"SAGAI Masaru"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tsukuba Institute for Healthy Life (Aomori University of Health and Welfare)"},{"@language":"ja","@value":"つくば健康生活研究所（青森県立保健大学・名誉教授）"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801192791936","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00391128"},{"@type":"NRID","@value":"1000000391128"},{"@type":"NRID","@value":"9000413771734"},{"@type":"NRID","@value":"9000398021382"},{"@type":"NRID","@value":"9000398796492"},{"@type":"NRID","@value":"9000412547435"},{"@type":"NRID","@value":"9000411633483"},{"@type":"NRID","@value":"9000410906066"},{"@type":"NRID","@value":"9000391991804"},{"@type":"NRID","@value":"9000398021614"},{"@type":"NRID","@value":"9000401955218"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/sama10887"}],"foaf:name":[{"@language":"ja","@value":"ウィンシュイ ティンティン"},{"@language":"en","@value":"Tin WIN-SHWE Tin"}],"jpcoar:affiliationName":[{"@language":"en","@value":"National Institute for Environmental Studies"},{"@language":"ja","@value":"独立行政法人・国立環境研究所環境健康研究センター生体影響研究室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00215082"},{"@type":"EISSN","@value":"18826482"},{"@type":"NDL_BIB_ID","@value":"000000018201"},{"@type":"ISSN","@value":"00215082"},{"@type":"LISSN","@value":"00215082"},{"@type":"NCID","@value":"AN00185923"}],"prism:publicationName":[{"@language":"ja","@value":"日本衛生学雑誌"},{"@language":"en","@value":"Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)"},{"@language":"en","@value":"Jpn. J. Hyg."},{"@language":"ja","@value":"日衛誌"},{"@language":"en","@value":"Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), Jpn. J. Hyg."},{"@language":"ja","@value":"日本衛生学雑誌、日衛誌"},{"@language":"en","@value":"Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society for Hygiene"},{"@language":"ja","@value":"一般社団法人日本衛生学会"}],"prism:publicationDate":"2015","prism:volume":"70","prism:number":"3","prism:startingPage":"220","prism:endingPage":"229"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/026796556"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I026796556"},{"@id":"https://www.jstage.jst.go.jp/article/jjh/70/3/70_220/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2016051592"}],"availableAt":"2015","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=PM2.5","dc:title":"PM2.5"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%87%E3%82%A3%E3%83%BC%E3%82%BC%E3%83%AB%E6%8E%92%E6%B0%97%E5%BE%AE%E7%B2%92%E5%AD%90","dc:title":"ディーゼル排気微粒子"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%8A%E3%83%8E%E7%B2%92%E5%AD%90","dc:title":"ナノ粒子"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%84%B3","dc:title":"脳"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%B4%BB%E6%80%A7%E9%85%B8%E7%B4%A0","dc:title":"活性酸素"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%A5%9E%E7%B5%8C%E6%AF%92%E6%80%A7","dc:title":"神経毒性"},{"@id":"https://cir.nii.ac.jp/all?q=PM2.5","dc:title":"PM2.5"},{"@id":"https://cir.nii.ac.jp/all?q=diesel%20exhaust%20particles","dc:title":"diesel 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